Dataset

GPCRrecent, six targets after the Boltz-2 training cutoff

The six GPCRrecent targets whose first crystal structures were released after Boltz-2's June 2023 training cutoff.

Evaluation results

2 evaluations · 20 results. Different protocols are not a single leaderboard.

Filter evaluations

Tested model or methodProtocolDatasetEvaluation setupMetricEvidence origin

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Boltz-2 (ipTM) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	0.717 AUROC (AUROC, mean over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (ipTM) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (ipTM) subseta', column 'AUROC' (Mean)
Configuration: Boltz-2 (ipTM) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	0.699 AUROC (AUROC, median over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (ipTM) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (ipTM) subseta', column 'AUROC' (Med)
Configuration: Boltz-2 (ipTM) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	0.23 Bedroc (BEDROC with alpha = 80.5, mean over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (ipTM) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (ipTM) subseta', column 'BEDROC (α = 80.5)' (Mean)
Configuration: Boltz-2 (ipTM) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	0.201 Bedroc (BEDROC with alpha = 80.5, median over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (ipTM) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (ipTM) subseta', column 'BEDROC (α = 80.5)' (Med)
Configuration: Boltz-2 (ipTM) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	15.8 Enrichment factor (EF at the top 0.5% of the ranked library, mean over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (ipTM) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (ipTM) subseta', column 'EF0.5%' (Mean)
Configuration: Boltz-2 (ipTM) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	13.6 Enrichment factor (EF at the top 0.5% of the ranked library, median over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (ipTM) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (ipTM) subseta', column 'EF0.5%' (Med)
Configuration: Boltz-2 (ipTM) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	12.6 Enrichment factor (EF at the top 1% of the ranked library, mean over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (ipTM) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (ipTM) subseta', column 'EF1%' (Mean)
Configuration: Boltz-2 (ipTM) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	10.9 Enrichment factor (EF at the top 1% of the ranked library, median over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (ipTM) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (ipTM) subseta', column 'EF1%' (Med)
Configuration: Boltz-2 (ipTM) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	5.17 Enrichment factor (EF at the top 5% of the ranked library, mean over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (ipTM) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (ipTM) subseta', column 'EF5%' (Mean)
Configuration: Boltz-2 (ipTM) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	4.84 Enrichment factor (EF at the top 5% of the ranked library, median over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (ipTM) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (ipTM) subseta', column 'EF5%' (Med)
Configuration: Boltz-2 (min-iPAE) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	0.764 AUROC (AUROC, mean over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (min-iPAE) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (min-iPAE) subseta', column 'AUROC' (Mean)
Configuration: Boltz-2 (min-iPAE) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	0.74 AUROC (AUROC, median over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (min-iPAE) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (min-iPAE) subseta', column 'AUROC' (Med)
Configuration: Boltz-2 (min-iPAE) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	0.287 Bedroc (BEDROC with alpha = 80.5, mean over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (min-iPAE) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (min-iPAE) subseta', column 'BEDROC (α = 80.5)' (Mean)
Configuration: Boltz-2 (min-iPAE) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	0.245 Bedroc (BEDROC with alpha = 80.5, median over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (min-iPAE) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (min-iPAE) subseta', column 'BEDROC (α = 80.5)' (Med)
Configuration: Boltz-2 (min-iPAE) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	19 Enrichment factor (EF at the top 0.5% of the ranked library, mean over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (min-iPAE) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (min-iPAE) subseta', column 'EF0.5%' (Mean)
Configuration: Boltz-2 (min-iPAE) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	17.6 Enrichment factor (EF at the top 0.5% of the ranked library, median over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (min-iPAE) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (min-iPAE) subseta', column 'EF0.5%' (Med)
Configuration: Boltz-2 (min-iPAE) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	14.3 Enrichment factor (EF at the top 1% of the ranked library, mean over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (min-iPAE) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (min-iPAE) subseta', column 'EF1%' (Mean)
Configuration: Boltz-2 (min-iPAE) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	12.5 Enrichment factor (EF at the top 1% of the ranked library, median over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (min-iPAE) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (min-iPAE) subseta', column 'EF1%' (Med)
Configuration: Boltz-2 (min-iPAE) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	6.83 Enrichment factor (EF at the top 5% of the ranked library, mean over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (min-iPAE) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (min-iPAE) subseta', column 'EF5%' (Mean)
Configuration: Boltz-2 (min-iPAE) as a screening score	Protocol: GPCRrecent screening (the six targets whose first structures postdate the Boltz-2 training cutoff) (Shen et al. 2025 Table 3) Dataset: GPCRrecent, six targets after the Boltz-2 training cutoff	5.87 Enrichment factor (EF at the top 5% of the ranked library, median over the 6 GPCRrecent targets) unitless · higher Uncertainty: Not reported by the source: The source prints no interval or spread for this value Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source Boltz-2 (min-iPAE) subset on GPCRrecent (Shen et al. 2025 Table 3) hitdisc-20261022-protocol-shen-gpcrrecent-6 Aggregation: Not reported Shen et al. 2025, Chemical Science (Europe PMC full text) · Table 3, row 'Boltz-2 (min-iPAE) subseta', column 'EF5%' (Med)

Source checking is not independent reproduction. Release 2026-10-22-1b7cf027e4f6.

Research readiness

0 of 4 readiness checks met. These checks assess whether the evidence supports a reproducible investigation; a source-checked score alone does not meet them.

Readiness checks, gaps and artifacts

Release 2026-10-22-1b7cf027e4f6 · Evidence verified: Not verified

Evidence incomplete

Replay metrics

Exact outcomes, predictions, identifiers and evaluator are connected.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
Metrics are recomputed from the saved predictions: not yet verified

Verified: Not verified

Evidence incomplete

Investigate discrepancies

Replay evidence includes annotations and an assessment of dependence. Unknown independence permits descriptive analysis only.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
Metrics are recomputed from the saved predictions: not yet verified
Sample annotations are recorded: not yet verified
Dependence between samples is assessed: not yet verified

Verified: Not verified

Evidence incomplete

Run locally

A pinned recipe describes the inputs, environment and resource requirements.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
A pinned run recipe exists: not yet verified
Compute requirements are estimated: not yet verified

Verified: Not verified

Evidence incomplete

Validate independently

Separate data and exposure records support an independent test.

Missing or unresolved evidence

No verified artifact manifest is linked to this exact record.
File checksums match the recorded files: not yet verified
Predictions are matched to the right samples: not yet verified
Score meaning and direction are confirmed: not yet verified
Independent validation data exist: not yet verified
Overlap with training data is checked: not yet verified

Verified: Not verified

Readiness describes the evidence in this release. Availability on your computer is checked separately when an investigation runs. Existing data exposure can prevent independent validation even when files are available.

Artifacts and reproduction

No verified artifact manifest is connected to this record yet. The gaps above identify what is needed before analysis can begin.

Dataset and evaluation context

A dataset supplies biological observations. The evaluation protocol defines how those observations are split, used and scored.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

7 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Population Six GPCR targets whose first crystal structures were released after 2023-06, the temporal cutoff of Boltz-2's training data Context-only references	Shen et al. 2025, Chemical Science (Europe PMC full text) Original source ↗ Table 3 footnote a; Results 'Performance on GPCRrecent dataset' Version: PMC12704515 (Chem Sci, published 2025-12-11) Retrieved: 2026-10-22T11:52:32Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.population` Source artifact SHA-256: `11a4cee97057d9e72f9393024d22fdd169e3134f493367eee2f7869facf9ccf8` Hash scope: Hash scope not separately documented; inspect source record
Source location Table 3 footnote a; Results 'Performance on GPCRrecent dataset' Context-only references	Shen et al. 2025, Chemical Science (Europe PMC full text) Original source ↗ Table 3 footnote a; Results 'Performance on GPCRrecent dataset' Version: PMC12704515 (Chem Sci, published 2025-12-11) Retrieved: 2026-10-22T11:52:32Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.source_locator` Source artifact SHA-256: `11a4cee97057d9e72f9393024d22fdd169e3134f493367eee2f7869facf9ccf8` Hash scope: Hash scope not separately documented; inspect source record
Split Six of the 16 GPCRrecent targets: UniProt O15552, P0DMS8, P13945, P35348, P46098, Q96RJ0 Context-only references	Shen et al. 2025, Chemical Science (Europe PMC full text) Original source ↗ Table 3 footnote a; Results 'Performance on GPCRrecent dataset' Version: PMC12704515 (Chem Sci, published 2025-12-11) Retrieved: 2026-10-22T11:52:32Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.split` Source artifact SHA-256: `11a4cee97057d9e72f9393024d22fdd169e3134f493367eee2f7869facf9ccf8` Hash scope: Hash scope not separately documented; inspect source record
Total targets 6 Context-only references	Shen et al. 2025, Chemical Science (Europe PMC full text) Original source ↗ Table 3 footnote a; Results 'Performance on GPCRrecent dataset' Version: PMC12704515 (Chem Sci, published 2025-12-11) Retrieved: 2026-10-22T11:52:32Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.total_targets` Source artifact SHA-256: `11a4cee97057d9e72f9393024d22fdd169e3134f493367eee2f7869facf9ccf8` Hash scope: Hash scope not separately documented; inspect source record
Version https://zenodo.org/records/16826965 (Data availability); no version string is printed Context-only references	Shen et al. 2025, Chemical Science (Europe PMC full text) Original source ↗ Table 3 footnote a; Results 'Performance on GPCRrecent dataset' Version: PMC12704515 (Chem Sci, published 2025-12-11) Retrieved: 2026-10-22T11:52:32Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.version` Source artifact SHA-256: `11a4cee97057d9e72f9393024d22fdd169e3134f493367eee2f7869facf9ccf8` Hash scope: Hash scope not separately documented; inspect source record
Description The six GPCRrecent targets whose first crystal structures were released after Boltz-2's June 2023 training cutoff. Context-only references	Shen et al. 2025, Chemical Science (Europe PMC full text) Original source ↗ Table 3 footnote a; Results 'Performance on GPCRrecent dataset' Version: PMC12704515 (Chem Sci, published 2025-12-11) Retrieved: 2026-10-22T11:52:32Z	not individually reviewed No individual claim review recorded Audit details Field: `description` Source artifact SHA-256: `11a4cee97057d9e72f9393024d22fdd169e3134f493367eee2f7869facf9ccf8` Hash scope: Hash scope not separately documented; inspect source record
Name GPCRrecent, six targets after the Boltz-2 training cutoff Context-only references	Shen et al. 2025, Chemical Science (Europe PMC full text) Original source ↗ Table 3 footnote a; Results 'Performance on GPCRrecent dataset' Version: PMC12704515 (Chem Sci, published 2025-12-11) Retrieved: 2026-10-22T11:52:32Z	not individually reviewed No individual claim review recorded Audit details Field: `name` Source artifact SHA-256: `11a4cee97057d9e72f9393024d22fdd169e3134f493367eee2f7869facf9ccf8` Hash scope: Hash scope not separately documented; inspect source record

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

Shen et al. 2025, Chemical Science (Europe PMC full text) · Original source · PMC12704515 (Chem Sci, published 2025-12-11)

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: hitdisc-20261022-dataset-gpcrrecent-6

areas: molecular-interactions
contexts: research
version: https://zenodo.org/records/16826965 (Data availability); no version string is printed
split: Six of the 16 GPCRrecent targets: UniProt O15552, P0DMS8, P13945, P35348, P46098, Q96RJ0
population: Six GPCR targets whose first crystal structures were released after 2023-06, the temporal cutoff of Boltz-2's training data
total targets: 6
source locator: Table 3 footnote a; Results 'Performance on GPCRrecent dataset'
review: method: scope-review; automated-source-review; reviewer: claude; reviewer note: Claude review agent, independent of the extraction agent; no human review claimed; date: 2026-10-22; method note: Read the record against the pinned sources and against docs/use-cases.md and docs/record-contract.md.; note: Record checked against the pinned source and the record contract. Transcription checked; not reproduced and not reviewed by a human scientist.; artifact sha256: 11a4cee97057d9e72f9393024d22fdd169e3134f493367eee2f7869facf9ccf8; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12704515/fullTextXML; receipt: data/omics/use-case-coverage-hitdisc-20261022/review.json

Related records

Suggest a correction