Configuration

BayesDel generic Pejaver evidence thresholds in ENIGMA comparison

Generic BP4 supporting threshold ≤−0.18 and PP3 supporting threshold ≥0.13, applied to BRCA functional benign reference sets. These are evidence codes, not full pathogenicity classifications.

2 evaluations · 4 results

Overview

Generic BP4 supporting threshold ≤−0.18 and PP3 supporting threshold ≥0.13, applied to BRCA functional benign reference sets. These are evidence codes, not full pathogenicity classifications.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

2 evaluations · 4 results. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: BayesDel generic Pejaver evidence thresholds in ENIGMA comparison	Protocol: BRCA1 generic BayesDel threshold evidence-code assignment Dataset: BRCA1 functional reference calibration set	<10% benign_reference_assigned_bp4 percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source BRCA1 generic BayesDel threshold comparator Not reported Aggregation: Not reported Evidence-based recommendations for gene-specific ACMG/AMP variant classification from the ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel · Results, BayesDel calibration, BP4 code would be assigned to <10% of BRCA1 and BRCA2 benign reference variants
Configuration: BayesDel generic Pejaver evidence thresholds in ENIGMA comparison	Protocol: BRCA1 generic BayesDel threshold evidence-code assignment Dataset: BRCA1 functional reference calibration set	29% benign_reference_assigned_pp3 percent · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source BRCA1 generic BayesDel threshold comparator Not reported Aggregation: Not reported Evidence-based recommendations for gene-specific ACMG/AMP variant classification from the ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel · Results, BayesDel calibration, sentence 29% for BRCA1 and 36% for BRCA2 incorrectly assigned PP3
Configuration: BayesDel generic Pejaver evidence thresholds in ENIGMA comparison	Protocol: BRCA2 generic BayesDel threshold evidence-code assignment Dataset: BRCA2 functional reference calibration set	<10% benign_reference_assigned_bp4 percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source BRCA2 generic BayesDel threshold comparator Not reported Aggregation: Not reported Evidence-based recommendations for gene-specific ACMG/AMP variant classification from the ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel · Results, BayesDel calibration, BP4 code would be assigned to <10% of BRCA1 and BRCA2 benign reference variants
Configuration: BayesDel generic Pejaver evidence thresholds in ENIGMA comparison	Protocol: BRCA2 generic BayesDel threshold evidence-code assignment Dataset: BRCA2 functional reference calibration set	36% benign_reference_assigned_pp3 percent · lower Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source BRCA2 generic BayesDel threshold comparator Not reported Aggregation: Not reported Evidence-based recommendations for gene-specific ACMG/AMP variant classification from the ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel · Results, BayesDel calibration, sentence 29% for BRCA1 and 36% for BRCA2 incorrectly assigned PP3

Source checking is not independent reproduction. Release 2026-09-30-e37e3ab1284d.

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Evidence

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Evidence table

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1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-09-30-e37e3ab1284d
Property and statement	Original source and location	Review and provenance
Relationship: variant of uc-clinical-20260930-method-bayesdel Individual claims	Evidence-based recommendations for gene-specific ACMG/AMP variant classification from the ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel Original source ↗ Results; Table 2; reference 22 Version: 2024 final article; reported VCEP specifications v1.0 Retrieved: 2026-09-30T21:24:15Z	source checked automated source review · 2026-09-30 Audit details Transcription from inspected primary source. No execution, independent replication or human scientific review. Field: `links:variant_of:uc-clinical-20260930-method-bayesdel` Claim: uc-clinical-20260930-association-bayesdel-pejaver-generic Source artifact SHA-256: `21e7b0792e18a1295b7bccb8b19ebe4432a2b047187139407c8616ea0cd531f2` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

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Release 2026-09-30-e37e3ab1284d · Record review: source checked

1 source records and release history

Evidence-based recommendations for gene-specific ACMG/AMP variant classification from the ClinGen ENIGMA BRCA1 and BRCA2 Variant Curation Expert Panel · Original source · 2024 final article; reported VCEP specifications v1.0

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Technical metadata and extraction receipts

Stable ID: uc-clinical-20260930-bayesdel-pejaver-generic

areas: dna-genomes
contexts: clinical_research
review: method: automated_source_review; reviewer: Codex clinical coverage worker; date: 2026-09-30; note: Transcription from inspected primary source. No execution, independent replication or human scientific review.; source id: uc-clinical-20260930-source-enigma
parent identity review: source id: uc-clinical-20260930-source-enigma; source locator: Results; Table 2; reference 22; method: automated_source_review

Related records

variant of: BayesDel
subject: Configuration identity: BayesDel generic Pejaver evidence thresholds in ENIGMA comparison
configuration: Generic BayesDel computational-evidence threshold baseline
configuration: BRCA1 generic BayesDel threshold comparator
configuration: BRCA2 generic BayesDel threshold comparator

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