Configuration

GPT-5.4 (AssayBench)

Configuration as run in the cited comparison.

Overview

Configuration as run in the cited comparison.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

3 evaluations · 9 results. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: GPT-5.4 (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench post-cutoff cohort of human CRISPR screens	0.0982 adjusted-ndcg-at-100 unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source GPT-5.4 on the AssayBench post-cutoff cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'GPT-5.4' cohort 'LaTest', column 'AnDCG@100'
Configuration: GPT-5.4 (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench post-cutoff cohort of human CRISPR screens	NA directional-false-discovery-rate-at-100 fraction · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source GPT-5.4 on the AssayBench post-cutoff cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'GPT-5.4' cohort 'LaTest', column 'dFDR@100'
Configuration: GPT-5.4 (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench post-cutoff cohort of human CRISPR screens	0.222 precision-at-100 fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source GPT-5.4 on the AssayBench post-cutoff cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'GPT-5.4' cohort 'LaTest', column 'Precision@100'
Configuration: GPT-5.4 (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench test cohort of human CRISPR screens	0.147 adjusted-ndcg-at-100 unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source GPT-5.4 on the AssayBench test cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'GPT-5.4' cohort 'test', column 'AnDCG@100'
Configuration: GPT-5.4 (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench test cohort of human CRISPR screens	0.0206 directional-false-discovery-rate-at-100 fraction · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source GPT-5.4 on the AssayBench test cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'GPT-5.4' cohort 'test', column 'dFDR@100'
Configuration: GPT-5.4 (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench test cohort of human CRISPR screens	0.198 precision-at-100 fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source GPT-5.4 on the AssayBench test cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'GPT-5.4' cohort 'test', column 'Precision@100'
Configuration: GPT-5.4 (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench validation cohort of human CRISPR screens	0.166 adjusted-ndcg-at-100 unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source GPT-5.4 on the AssayBench validation cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'GPT-5.4' cohort 'val', column 'AnDCG@100'
Configuration: GPT-5.4 (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench validation cohort of human CRISPR screens	0.0162 directional-false-discovery-rate-at-100 fraction · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source GPT-5.4 on the AssayBench validation cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'GPT-5.4' cohort 'val', column 'dFDR@100'
Configuration: GPT-5.4 (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench validation cohort of human CRISPR screens	0.326 precision-at-100 fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source GPT-5.4 on the AssayBench validation cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'GPT-5.4' cohort 'val', column 'Precision@100'

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Evidence

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Sources and history

Release 2026-10-10-6e93f504adfc · Record review: source checked

1 source records and release history

AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Original source · arXiv:2605.10876 version 1, posted 2026-05-11; not peer reviewed

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Technical metadata and extraction receipts

Stable ID: tgtval-20261009-config-debrouwer2026-gpt-5-4

areas: cells-tissues
contexts: research
method types: foundation_model
reported name: GPT-5.4
foundation model eligible: true
source locator: Tables 2-3 row labels; section 4
missing metadata: version: reason: unreported; note: No release or commit is printed for this configuration
parameters: zero-shot

Related records

configuration of: GPT-5.4
system: GPT-5.4 on the AssayBench post-cutoff cohort
system: GPT-5.4 on the AssayBench test cohort
system: GPT-5.4 on the AssayBench validation cohort

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