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Biomni A1 (Claude 4) (AssayBench)

Biomni A1 (Claude 4): biomedical agent with tool access, Claude 4 backbone.

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Evaluations and results

3 evaluations · 9 results. Different protocols are not a single leaderboard.

Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen

Sorted by Adjusted NDCG at 100 (post-cutoff cohort; mean over benchmark entries) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	Protocol and dataset	Adjusted NDCG at 100 (post-cutoff cohort; mean over benchmark entries)	Adjusted NDCG at 100 (test cohort; mean over benchmark entries)	Adjusted NDCG at 100 (validation cohort; mean over benchmark entries)	Directional false discovery rate at 100 (post-cutoff cohort; mean over benchmark entries)	Directional false discovery rate at 100 (test cohort; mean over benchmark entries)	Directional false discovery rate at 100 (validation cohort; mean over benchmark entries)	Precision at 100 (post-cutoff cohort; mean over benchmark entries; denominator min(100, positive-relevance genes))	Precision at 100 (test cohort; mean over benchmark entries; denominator min(100, positive-relevance genes))	Precision at 100 (validation cohort; mean over benchmark entries; denominator min(100, positive-relevance genes))
Biomni A1 (Claude 4) (AssayBench)Evaluation	AssayBench post-cutoff cohort of human CRISPR screens	0.0728	Not reported	Not reported	NA	Not reported	Not reported	0.0214	Not reported	Not reported
Biomni A1 (Claude 4) (AssayBench)Evaluation	AssayBench test cohort of human CRISPR screens	Not reported	0.108	Not reported	Not reported	0.0176	Not reported	Not reported	0.17	Not reported
Biomni A1 (Claude 4) (AssayBench)Evaluation	AssayBench validation cohort of human CRISPR screens	Not reported	Not reported	0.141	Not reported	Not reported	0.0164	Not reported	Not reported	0.247

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Biomni A1 (Claude 4) (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench post-cutoff cohort of human CRISPR screens	0.0728 Adjusted NDCG at 100 (post-cutoff cohort; mean over benchmark entries) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Biomni A1 (Claude 4) on the AssayBench post-cutoff cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'Biomni A1 (Claude 4)' cohort 'LaTest', column 'AnDCG@100'
Configuration: Biomni A1 (Claude 4) (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench post-cutoff cohort of human CRISPR screens	NA Directional false discovery rate at 100 (post-cutoff cohort; mean over benchmark entries) fraction · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Biomni A1 (Claude 4) on the AssayBench post-cutoff cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'Biomni A1 (Claude 4)' cohort 'LaTest', column 'dFDR@100'
Configuration: Biomni A1 (Claude 4) (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench post-cutoff cohort of human CRISPR screens	0.0214 Precision at 100 (post-cutoff cohort; mean over benchmark entries; denominator min(100, positive-relevance genes)) fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Biomni A1 (Claude 4) on the AssayBench post-cutoff cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'Biomni A1 (Claude 4)' cohort 'LaTest', column 'Precision@100'
Configuration: Biomni A1 (Claude 4) (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench test cohort of human CRISPR screens	0.108 Adjusted NDCG at 100 (test cohort; mean over benchmark entries) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Biomni A1 (Claude 4) on the AssayBench test cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'Biomni A1 (Claude 4)' cohort 'test', column 'AnDCG@100'
Configuration: Biomni A1 (Claude 4) (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench test cohort of human CRISPR screens	0.0176 Directional false discovery rate at 100 (test cohort; mean over benchmark entries) fraction · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Biomni A1 (Claude 4) on the AssayBench test cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'Biomni A1 (Claude 4)' cohort 'test', column 'dFDR@100'
Configuration: Biomni A1 (Claude 4) (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench test cohort of human CRISPR screens	0.17 Precision at 100 (test cohort; mean over benchmark entries; denominator min(100, positive-relevance genes)) fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Biomni A1 (Claude 4) on the AssayBench test cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'Biomni A1 (Claude 4)' cohort 'test', column 'Precision@100'
Configuration: Biomni A1 (Claude 4) (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench validation cohort of human CRISPR screens	0.141 Adjusted NDCG at 100 (validation cohort; mean over benchmark entries) unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Biomni A1 (Claude 4) on the AssayBench validation cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'Biomni A1 (Claude 4)' cohort 'val', column 'AnDCG@100'
Configuration: Biomni A1 (Claude 4) (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench validation cohort of human CRISPR screens	0.0164 Directional false discovery rate at 100 (validation cohort; mean over benchmark entries) fraction · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Biomni A1 (Claude 4) on the AssayBench validation cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'Biomni A1 (Claude 4)' cohort 'val', column 'dFDR@100'
Configuration: Biomni A1 (Claude 4) (AssayBench)	Protocol: AssayBench: rank 100 candidate genes for a described CRISPR screen Dataset: AssayBench validation cohort of human CRISPR screens	0.247 Precision at 100 (validation cohort; mean over benchmark entries; denominator min(100, positive-relevance genes)) fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Biomni A1 (Claude 4) on the AssayBench validation cohort tgtval-20261009-protocol-debrouwer2026-screen-gene-ranking Aggregation: Not reported AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Table 3, row 'Biomni A1 (Claude 4)' cohort 'val', column 'Precision@100'

Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.

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Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

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AssayBench: An Assay-Level Virtual Cell Benchmark for LLMs and Agents · Original source · arXiv:2605.10876 version 1, posted 2026-05-11; not peer reviewed

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Technical metadata and extraction receipts

Stable ID: tgtval-20261009-config-debrouwer2026-biomni-a1-claude-4

areas: cells-tissues
contexts: research
method types: foundation_model
reported name: Biomni A1 (Claude 4)
foundation model eligible: true
source locator: Tables 2-3 row labels; section 4
missing metadata: version: reason: unreported; note: No release or commit is printed for this configuration
parameters: biomedical agent with tool access, Claude 4 backbone
provenance note: Configuration as run in the cited comparison.

Related records

configuration of: Biomni A1
system: Biomni A1 (Claude 4) on the AssayBench post-cutoff cohort
system: Biomni A1 (Claude 4) on the AssayBench test cohort
system: Biomni A1 (Claude 4) on the AssayBench validation cohort

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