Configuration

MMSplice (Znabu et al. 2026)

Configuration of MMSplice: Magnitude of delta logit PSI; each MFASS exon reconstructed as an internal cassette exon; hg38 genomic context.

1 evaluation · 3 results

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Evaluations and results

1 evaluation · 3 results. Different protocols are not a single leaderboard.

Protocol: MFASS splice-disrupting variant detection, all 27,733 labelled SNVs (Znabu et al. 2026) · Dataset: MFASS v2 eligible assay cohort

Sorted by AUROC (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configuration	AUROC	Average precision	Count (variants scored)
MMSplice (Znabu et al. 2026)Evaluation	0.758	0.256	27,733

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: MMSplice (Znabu et al. 2026)	Protocol: MFASS splice-disrupting variant detection, all 27,733 labelled SNVs (Znabu et al. 2026) Dataset: MFASS v2 eligible assay cohort	0.256 Average precision unitless · higher Uncertainty: 95% CI 0.226 to 0.285 Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source MMSplice on all labelled MFASS SNVs splicing-follow-up-20261009-protocol-znabu2026-mfass-full-cohort Aggregation: Not reported A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot · Section 4 'Results' table (page 3), row 'MMSplice', columns 'AP' and 'AP 95% CI'
Configuration: MMSplice (Znabu et al. 2026)	Protocol: MFASS splice-disrupting variant detection, all 27,733 labelled SNVs (Znabu et al. 2026) Dataset: MFASS v2 eligible assay cohort	0.758 AUROC unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source MMSplice on all labelled MFASS SNVs splicing-follow-up-20261009-protocol-znabu2026-mfass-full-cohort Aggregation: Not reported A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot · Section 4 'Results' table (page 3), row 'MMSplice', column 'AUROC'
Configuration: MMSplice (Znabu et al. 2026)	Protocol: MFASS splice-disrupting variant detection, all 27,733 labelled SNVs (Znabu et al. 2026) Dataset: MFASS v2 eligible assay cohort	27,733 Count (variants scored) count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source MMSplice on all labelled MFASS SNVs splicing-follow-up-20261009-protocol-znabu2026-mfass-full-cohort Aggregation: Not reported A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot · Section 4 'Results' table (page 3), row 'MMSplice', column 'n'

Source checking is not independent reproduction. Release 2026-11-02-a7f03c9e55a5.

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Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

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A Reproducible MFASS Benchmark of Splice-Disruption Predictors Reveals a Shared Exon-Interior Blind Spot · Original source · bioRxiv 2026.07.21.739871 v1, posted 2026-07-26; full-text PDF

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Technical metadata and extraction receipts

Stable ID: splicing-follow-up-20261009-config-znabu2026-mmsplice

areas: dna-genomes
contexts: research
method types: supervised_machine_learning
reported name: MMSplice (Znabu et al. 2026)
foundation model eligible: false
missing metadata: version: reason: unreported; note: Released weights used; software version not printed
parameters: Magnitude of delta logit PSI; each MFASS exon reconstructed as an internal cassette exon; hg38 genomic context
source locator: Section 3 'Predictors and scoring'
provenance note: MMSplice (Znabu et al. 2026) as run in the cited comparison.

Related records

configuration of: MMSplice
system: MMSplice on all labelled MFASS SNVs

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