Configuration

CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)

CLARK on Trimmomatic-trimmed reads, all trimmed reads (human reads included).

Overview

CLARK on Trimmomatic-trimmed reads, all trimmed reads (human reads included).

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Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort · Original source · Pathogens 11(3):340, published 2022-03-11; PMC8953373 full-text XML
Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Original source · medRxiv 2022.01.21.22269647 version 1 (2022-01-21), supplementary file media-1.xlsx

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Technical metadata and extraction receipts

Stable ID: rna-pathogen-20261009-config-carbo2022-clark-incl-human

areas: microbes-communities
contexts: clinical_research
method types: conventional_pipeline
reported name: CLARK
source locator: Section 2.5; 2.6.2; Table 2 column 'Clark'; Section 2.3 (pre-processing)
foundation model eligible: false
version: 1.2.6.1
parameters: Viral NCBI RefSeq genomes downloaded 2020-12-27; default execution mode. Pre-processing: Trimmomatic v0.36 trimming, adapter clipping and low-complexity filtering; all trimmed reads (human reads included).

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Exact evaluated configurations and original reported results
Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	0.963 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell D9, row 'CLARK', column 'AUC'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	39.3 regression-intercept unitless · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell J9, row 'CLARK', column 'LR intercept'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	36.6% pearson-r-squared percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell K9, row 'CLARK', column 'LR r2, %'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	-2.73 regression-slope unitless · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell I9, row 'CLARK', column 'LR slope'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	0.997 negative-predictive-value fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell H9, row 'CLARK', column 'NPV (ROC)'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	0.229 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell G9, row 'CLARK', column 'PPV (ROC)'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	0.127 roc-distance unitless · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell C9, row 'CLARK', column 'Informedness'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	0.917 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell E9, row 'CLARK', column 'SN (ROC)'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	0.904 specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell F9, row 'CLARK', column 'SL (ROC)'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	5 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell L9, row 'CLARK', column 'Taxa'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, family level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	5 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): family level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-family-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Family', block 'incl. human reads', cell M9, row 'CLARK', column 'Taxa with reads >0'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, genus level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	0.947 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): genus level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-genus-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Genus', block 'incl. human reads', cell D10, row 'CLARK', column 'AUC'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, genus level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	35.2 regression-intercept unitless · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): genus level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-genus-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Genus', block 'incl. human reads', cell J10, row 'CLARK', column 'LR intercept'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, genus level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	34.9% pearson-r-squared percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): genus level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-genus-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Genus', block 'incl. human reads', cell K10, row 'CLARK', column 'LR r2, %'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, genus level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	-1.95 regression-slope unitless · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): genus level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-genus-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Genus', block 'incl. human reads', cell I10, row 'CLARK', column 'LR slope'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, genus level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	0.997 negative-predictive-value fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): genus level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-genus-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Genus', block 'incl. human reads', cell H10, row 'CLARK', column 'NPV (ROC)'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, genus level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	0.244 precision fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): genus level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-genus-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Genus', block 'incl. human reads', cell G10, row 'CLARK', column 'PPV (ROC)'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, genus level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	0.122 roc-distance unitless · lower Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): genus level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-genus-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Genus', block 'incl. human reads', cell C10, row 'CLARK', column 'Informedness'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, genus level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	0.917 recall fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): genus level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-genus-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Genus', block 'incl. human reads', cell E10, row 'CLARK', column 'SN (ROC)'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, genus level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	0.911 specificity fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): genus level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-genus-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Genus', block 'incl. human reads', cell F10, row 'CLARK', column 'SL (ROC)'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, genus level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	10 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): genus level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-genus-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Genus', block 'incl. human reads', cell L10, row 'CLARK', column 'Taxa'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, genus level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	10 count count · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): genus level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-genus-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Genus', block 'incl. human reads', cell M10, row 'CLARK', column 'Taxa with reads >0'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, species level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	0.949 auroc unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): species level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-species-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Species', block 'incl. human reads', cell D9, row 'CLARK', column 'AUC'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, species level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	32.4 regression-intercept unitless · unknown Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): species level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-species-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Species', block 'incl. human reads', cell J9, row 'CLARK', column 'LR intercept'
Configuration: CLARK, all trimmed reads (human reads included) (Carbo et al. 2022)	Protocol: Respiratory virus detection against PCR, species level, read-count cut-off 0 (Carbo et al. 2022 Supplementary Table 1) Dataset: Nasal washings from COPD patients with respiratory complaints, metagenomic sequencing and 13-target respiratory PCR panel (Carbo et al. 2022)	15.1% pearson-r-squared percent · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source CLARK, all trimmed reads (human reads included): species level, read-count cut-off 0 (Carbo et al. 2022) rna-pathogen-20261009-protocol-carbo2022-species-cutoff-0 Aggregation: Not reported Carbo et al. medRxiv preprint v1, Supplementary Tables 1 and 2 · Supplementary Table 1 sheet 'Suppl table 1-Species', block 'incl. human reads', cell K9, row 'CLARK', column 'LR r2, %'