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Union of six long-read callers on ONT PCR-cDNA (Dorney et al. 2026)

Union of six long-read callers applied to Huh7 ONT PCR-cDNA libraries.

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Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: Union of six long-read callers on ONT PCR-cDNA (Dorney et al. 2026)	Protocol: Huh7 recovery of 34 previously reported fusions by library type, union of callers (Dorney et al. 2026) Dataset: Huh7 hepatocellular carcinoma cell line RNA-seq: ONT direct RNA, direct cDNA, PCR-cDNA, PacBio Kinnex and Illumina NovaSeq (Dorney et al. 2026)	17 True positives (known Huh7 fusions recovered of 34, union of callers) count · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible	Independent external evaluation · Source checked Methods, coverage and source Union of six long-read callers on Huh7 ONT PCR-cDNA (Dorney et al. 2026) rna-fusion-longread-20261011-protocol-huh7-known-fusions Aggregation: Not reported A comprehensive benchmark of transcriptome-wide fusion detection using long-read RNA sequencing; LRFusionBenchmark repository (Dorney et al.): result tables and run scripts · Results 'PCR-cDNA libraries provide the most consistent recovery of validated fusion transcripts' paragraph 2: 'ONT PCR-cDNA ... (17)'

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Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

2 source records and release history

A comprehensive benchmark of transcriptome-wide fusion detection using long-read RNA sequencing · Original source · bioRxiv preprint version 1, posted 2026-08-12; JATS XML
LRFusionBenchmark repository (Dorney et al.): result tables and run scripts · Original source · Git commit 83e629fed3098881079fd9ac1c8bc13478ce69ed (pushed 2026-08-25); files: Figures/Input_dataframes/stat_summary.tsv, Figures/Input_dataframes/counts_SGNex_summary.tsv.gz, Fusions/runtools/Run_GFSLGF.sh, Fusions/runtools/RunJAFFAL.sh, Fusions/runtools/RunCTAT-LR-fusion.sh, Fusions/runtools/RunGFSeeker.sh, SimulatedData/Data_Analysis_Scripts/Precision_Recall_ReadSupp_stats.R, CellLineData/SGNex_DiscoveryNRecall.R

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Technical metadata and extraction receipts

Stable ID: rna-fusion-longread-20261011-config-union-ont-pcr-cdna

areas: rna-transcriptomes
contexts: clinical_research
method types: conventional_pipeline
reported name: ONT PCR-cDNA
foundation model eligible: false
parameters: Union of six long-read callers; calls with at least two spanning reads or pairs
access reuse: Public open-source callers
source locator: Figure 4 legend (C-E)
missing metadata: version: reason: inapplicable; note: Combination of callers; individual versions partly unreported

Related records

configuration of: Union of fusion callers
system: Union of six long-read callers on Huh7 ONT PCR-cDNA (Dorney et al. 2026)

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