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I-Mutant3.0-Seq (Pancotti et al. 2022)

I-Mutant3.0-Seq as evaluated in the cited comparison.

1 evaluation · 11 results

Overview

I-Mutant3.0-Seq as evaluated in the cited comparison.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

1 evaluation · 11 results. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: I-Mutant3.0-Seq (Pancotti et al. 2022)Protocol: S669 direct and reverse ddG prediction (Pancotti et al. 2022 Table 1)
Dataset: S669: 669 single-point variants from ThermoMutDB in proteins under 25% identity to S2648 and VariBench, with reverse variants
–0.48 pearson-correlation
unitless · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

I-Mutant3.0-Seq on S669 (Pancotti et al. 2022)

protein-stability-20261009-protocol-pancotti2022-s669

Aggregation: Not reported

Predicting protein stability changes upon single-point mutation: a thorough comparison of the available tools on a new dataset · Table 1, row 'I-Mutant3.0-Seq', column 'Antisimmetry r(d-r)'
Configuration: I-Mutant3.0-Seq (Pancotti et al. 2022)Protocol: S669 direct and reverse ddG prediction (Pancotti et al. 2022 Table 1)
Dataset: S669: 669 single-point variants from ThermoMutDB in proteins under 25% identity to S2648 and VariBench, with reverse variants
–0.76 antisymmetry-bias
kilocalorie-per-mole · unknown

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

I-Mutant3.0-Seq on S669 (Pancotti et al. 2022)

protein-stability-20261009-protocol-pancotti2022-s669

Aggregation: Not reported

Predicting protein stability changes upon single-point mutation: a thorough comparison of the available tools on a new dataset · Table 1, row 'I-Mutant3.0-Seq', column 'Bias'
Configuration: I-Mutant3.0-Seq (Pancotti et al. 2022)Protocol: S669 direct and reverse ddG prediction (Pancotti et al. 2022 Table 1)
Dataset: S669: 669 single-point variants from ThermoMutDB in proteins under 25% identity to S2648 and VariBench, with reverse variants
1.15 mean-absolute-error
kilocalorie-per-mole · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

I-Mutant3.0-Seq on S669 (Pancotti et al. 2022)

protein-stability-20261009-protocol-pancotti2022-s669

Aggregation: Not reported

Predicting protein stability changes upon single-point mutation: a thorough comparison of the available tools on a new dataset · Table 1, row 'I-Mutant3.0-Seq', column 'Direct MAE'
Configuration: I-Mutant3.0-Seq (Pancotti et al. 2022)Protocol: S669 direct and reverse ddG prediction (Pancotti et al. 2022 Table 1)
Dataset: S669: 669 single-point variants from ThermoMutDB in proteins under 25% identity to S2648 and VariBench, with reverse variants
0.34 pearson-correlation
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

I-Mutant3.0-Seq on S669 (Pancotti et al. 2022)

protein-stability-20261009-protocol-pancotti2022-s669

Aggregation: Not reported

Predicting protein stability changes upon single-point mutation: a thorough comparison of the available tools on a new dataset · Table 1, row 'I-Mutant3.0-Seq', column 'Direct r'
Configuration: I-Mutant3.0-Seq (Pancotti et al. 2022)Protocol: S669 direct and reverse ddG prediction (Pancotti et al. 2022 Table 1)
Dataset: S669: 669 single-point variants from ThermoMutDB in proteins under 25% identity to S2648 and VariBench, with reverse variants
1.54 root-mean-squared-error
kilocalorie-per-mole · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

I-Mutant3.0-Seq on S669 (Pancotti et al. 2022)

protein-stability-20261009-protocol-pancotti2022-s669

Aggregation: Not reported

Predicting protein stability changes upon single-point mutation: a thorough comparison of the available tools on a new dataset · Table 1, row 'I-Mutant3.0-Seq', column 'Direct RMSE'
Configuration: I-Mutant3.0-Seq (Pancotti et al. 2022)Protocol: S669 direct and reverse ddG prediction (Pancotti et al. 2022 Table 1)
Dataset: S669: 669 single-point variants from ThermoMutDB in proteins under 25% identity to S2648 and VariBench, with reverse variants
1.79 mean-absolute-error
kilocalorie-per-mole · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

I-Mutant3.0-Seq on S669 (Pancotti et al. 2022)

protein-stability-20261009-protocol-pancotti2022-s669

Aggregation: Not reported

Predicting protein stability changes upon single-point mutation: a thorough comparison of the available tools on a new dataset · Table 1, row 'I-Mutant3.0-Seq', column 'Reverse MAE'
Configuration: I-Mutant3.0-Seq (Pancotti et al. 2022)Protocol: S669 direct and reverse ddG prediction (Pancotti et al. 2022 Table 1)
Dataset: S669: 669 single-point variants from ThermoMutDB in proteins under 25% identity to S2648 and VariBench, with reverse variants
0.22 pearson-correlation
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

I-Mutant3.0-Seq on S669 (Pancotti et al. 2022)

protein-stability-20261009-protocol-pancotti2022-s669

Aggregation: Not reported

Predicting protein stability changes upon single-point mutation: a thorough comparison of the available tools on a new dataset · Table 1, row 'I-Mutant3.0-Seq', column 'Reverse r'
Configuration: I-Mutant3.0-Seq (Pancotti et al. 2022)Protocol: S669 direct and reverse ddG prediction (Pancotti et al. 2022 Table 1)
Dataset: S669: 669 single-point variants from ThermoMutDB in proteins under 25% identity to S2648 and VariBench, with reverse variants
2.22 root-mean-squared-error
kilocalorie-per-mole · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

I-Mutant3.0-Seq on S669 (Pancotti et al. 2022)

protein-stability-20261009-protocol-pancotti2022-s669

Aggregation: Not reported

Predicting protein stability changes upon single-point mutation: a thorough comparison of the available tools on a new dataset · Table 1, row 'I-Mutant3.0-Seq', column 'Reverse RMSE'
Configuration: I-Mutant3.0-Seq (Pancotti et al. 2022)Protocol: S669 direct and reverse ddG prediction (Pancotti et al. 2022 Table 1)
Dataset: S669: 669 single-point variants from ThermoMutDB in proteins under 25% identity to S2648 and VariBench, with reverse variants
1.47 mean-absolute-error
kilocalorie-per-mole · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

I-Mutant3.0-Seq on S669 (Pancotti et al. 2022)

protein-stability-20261009-protocol-pancotti2022-s669

Aggregation: Not reported

Predicting protein stability changes upon single-point mutation: a thorough comparison of the available tools on a new dataset · Table 1, row 'I-Mutant3.0-Seq', column 'Total MAE'
Configuration: I-Mutant3.0-Seq (Pancotti et al. 2022)Protocol: S669 direct and reverse ddG prediction (Pancotti et al. 2022 Table 1)
Dataset: S669: 669 single-point variants from ThermoMutDB in proteins under 25% identity to S2648 and VariBench, with reverse variants
0.37 pearson-correlation
unitless · higher

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

I-Mutant3.0-Seq on S669 (Pancotti et al. 2022)

protein-stability-20261009-protocol-pancotti2022-s669

Aggregation: Not reported

Predicting protein stability changes upon single-point mutation: a thorough comparison of the available tools on a new dataset · Table 1, row 'I-Mutant3.0-Seq', column 'Total r'
Configuration: I-Mutant3.0-Seq (Pancotti et al. 2022)Protocol: S669 direct and reverse ddG prediction (Pancotti et al. 2022 Table 1)
Dataset: S669: 669 single-point variants from ThermoMutDB in proteins under 25% identity to S2648 and VariBench, with reverse variants
1.91 root-mean-squared-error
kilocalorie-per-mole · lower

Uncertainty: Not reported by the source

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

I-Mutant3.0-Seq on S669 (Pancotti et al. 2022)

protein-stability-20261009-protocol-pancotti2022-s669

Aggregation: Not reported

Predicting protein stability changes upon single-point mutation: a thorough comparison of the available tools on a new dataset · Table 1, row 'I-Mutant3.0-Seq', column 'Total RMSE'

Source checking is not independent reproduction. Release 2026-10-10-6e93f504adfc.

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Evidence

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Release 2026-10-10-6e93f504adfc · Record review: source checked

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Technical metadata and extraction receipts

Stable ID: protein-stability-20261009-config-pancotti2022-i-mutant3-0-seq

areas
proteins-complexes
contexts
research
method types
supervised_machine_learning
reported name
I-Mutant3.0-Seq
foundation model eligible
false
protocol
Default parameters; sequence-based (Table 1 group)
source locator
Section 2.2 'Evaluated methods'; Table 1
missing metadata
version: reason: unextracted; note: Versions and servers are in the Supplementary Materials, not read in this pass
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