ESM therm (Chu et al. 2024)
ESM therm as evaluated in the cited comparison.
Overview
ESM therm as evaluated in the cited comparison.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluations and results
7 evaluations · 7 results. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: ESM therm (Chu et al. 2024) | Protocol: Acetyltransferase dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: Acetyltransferase dataset: Gentamicin 3-N-acetyltransferase, chemical stability | 0.03 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM therm on Acetyltransferase dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-acetyltransferase Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'Acetyltransferase dataset', column 'ESMtherm' (supervised group) |
| Configuration: ESM therm (Chu et al. 2024) | Protocol: Bgl3 dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: Bgl3 dataset: Beta-glucosidase (Bgl3), catalytic susceptibility to heat shock | 0.06 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM therm on Bgl3 dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-bgl3 Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'Bgl3 dataset', column 'ESMtherm' (supervised group) |
| Configuration: ESM therm (Chu et al. 2024) | Protocol: BglB dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: BglB dataset: Beta-glucosidase (BglB), melting temperature (Tm) | -0.11 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM therm on BglB dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-bglb Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'BglB dataset', column 'ESMtherm' (supervised group) |
| Configuration: ESM therm (Chu et al. 2024) | Protocol: Lipase EstA dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: Lipase EstA dataset: Lipase EstA, melting temperature (T50) | 0.04 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM therm on Lipase EstA dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-lipase-esta Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'Lipase EstA dataset', column 'ESMtherm' (supervised group) |
| Configuration: ESM therm (Chu et al. 2024) | Protocol: Mega-scale dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: Mega-scale dataset: multiple, cDNA display proteolysis | 0.65 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM therm on Mega-scale dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-mega-scale Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'Mega-scale dataset', column 'ESMtherm' (supervised group) |
| Configuration: ESM therm (Chu et al. 2024) | Protocol: Methyltransferase dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: Methyltransferase dataset: Thiopurine S-methyltransferase, protein abundance | 0.03 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM therm on Methyltransferase dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-methyltransferase Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'Methyltransferase dataset', column 'ESMtherm' (supervised group) |
| Configuration: ESM therm (Chu et al. 2024) | Protocol: PTEN dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: PTEN dataset: PTEN, protein abundance | 0.04 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceESM therm on PTEN dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-pten Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'PTEN dataset', column 'ESMtherm' (supervised group) |
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Evidence
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Sources and history
Release 2026-10-10-6e93f504adfc · Record review: source checked
1 source records and release history
- Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Original source · PLOS Computational Biology 20(7):e1012248, published 2024-07-22; PMC11293664 full-text XML
Technical metadata and extraction receipts
Stable ID: protein-stability-20261009-config-chu2024-esm-therm
- areas
- proteins-complexes
- contexts
- research
- method types
- supervised_machine_learning
- reported name
- ESM therm
- foundation model eligible
- false
- source locator
- Table 1 column header; Results 'Benchmarking on larger proteins'
- protocol
- Fine-tuned by the authors on the mega-scale dataset (35M ESM-2 backbone)
- missing metadata
- version: reason: unreported; note: No release number printed
Related records
- configuration of: ESM therm
- uses model: ESM-2
- system: ESM therm on Acetyltransferase dataset (Chu et al. 2024)
- system: ESM therm on Bgl3 dataset (Chu et al. 2024)
- system: ESM therm on BglB dataset (Chu et al. 2024)
- system: ESM therm on Lipase EstA dataset (Chu et al. 2024)
- system: ESM therm on Mega-scale dataset (Chu et al. 2024)
- system: ESM therm on Methyltransferase dataset (Chu et al. 2024)
- system: ESM therm on PTEN dataset (Chu et al. 2024)