ELASPIC-2 (Chu et al. 2024)
ELASPIC-2 as evaluated in the cited comparison.
Overview
ELASPIC-2 as evaluated in the cited comparison.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluations and results
7 evaluations · 7 results. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: ELASPIC-2 (Chu et al. 2024) | Protocol: Acetyltransferase dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: Acetyltransferase dataset: Gentamicin 3-N-acetyltransferase, chemical stability | 0.49 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceELASPIC-2 on Acetyltransferase dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-acetyltransferase Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'Acetyltransferase dataset', column 'ELASPIC-2' (supervised group) |
| Configuration: ELASPIC-2 (Chu et al. 2024) | Protocol: Bgl3 dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: Bgl3 dataset: Beta-glucosidase (Bgl3), catalytic susceptibility to heat shock | 0.56 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceELASPIC-2 on Bgl3 dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-bgl3 Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'Bgl3 dataset', column 'ELASPIC-2' (supervised group) |
| Configuration: ELASPIC-2 (Chu et al. 2024) | Protocol: BglB dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: BglB dataset: Beta-glucosidase (BglB), melting temperature (Tm) | -0.11 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceELASPIC-2 on BglB dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-bglb Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'BglB dataset', column 'ELASPIC-2' (supervised group) |
| Configuration: ELASPIC-2 (Chu et al. 2024) | Protocol: Lipase EstA dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: Lipase EstA dataset: Lipase EstA, melting temperature (T50) | 0.47 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceELASPIC-2 on Lipase EstA dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-lipase-esta Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'Lipase EstA dataset', column 'ELASPIC-2' (supervised group) |
| Configuration: ELASPIC-2 (Chu et al. 2024) | Protocol: Mega-scale dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: Mega-scale dataset: multiple, cDNA display proteolysis | 0.64 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceELASPIC-2 on Mega-scale dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-mega-scale Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'Mega-scale dataset', column 'ELASPIC-2' (supervised group) |
| Configuration: ELASPIC-2 (Chu et al. 2024) | Protocol: Methyltransferase dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: Methyltransferase dataset: Thiopurine S-methyltransferase, protein abundance | 0.58 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceELASPIC-2 on Methyltransferase dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-methyltransferase Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'Methyltransferase dataset', column 'ELASPIC-2' (supervised group) |
| Configuration: ELASPIC-2 (Chu et al. 2024) | Protocol: PTEN dataset stability ranking, Spearman correlation (Chu et al. 2024 Table 1) Dataset: PTEN dataset: PTEN, protein abundance | 0.47 spearman-correlation unitless · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceELASPIC-2 on PTEN dataset (Chu et al. 2024) protein-stability-20261009-protocol-chu2024-pten Aggregation: Not reported Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Table 1, row 'PTEN dataset', column 'ELASPIC-2' (supervised group) |
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Sources and history
Release 2026-10-10-6e93f504adfc · Record review: source checked
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- Protein stability prediction by fine-tuning a protein language model on a mega-scale dataset · Original source · PLOS Computational Biology 20(7):e1012248, published 2024-07-22; PMC11293664 full-text XML
Technical metadata and extraction receipts
Stable ID: protein-stability-20261009-config-chu2024-elaspic-2
- areas
- proteins-complexes
- contexts
- research
- method types
- supervised_machine_learning
- reported name
- ELASPIC-2
- foundation model eligible
- false
- source locator
- Table 1 column header; Results 'Benchmarking on larger proteins'
- protocol
- Published model or software, scored by the authors
- missing metadata
- version: reason: unreported; note: No release number printed
Related records
- configuration of: ELASPIC-2
- system: ELASPIC-2 on Acetyltransferase dataset (Chu et al. 2024)
- system: ELASPIC-2 on Bgl3 dataset (Chu et al. 2024)
- system: ELASPIC-2 on BglB dataset (Chu et al. 2024)
- system: ELASPIC-2 on Lipase EstA dataset (Chu et al. 2024)
- system: ELASPIC-2 on Mega-scale dataset (Chu et al. 2024)
- system: ELASPIC-2 on Methyltransferase dataset (Chu et al. 2024)
- system: ELASPIC-2 on PTEN dataset (Chu et al. 2024)