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Configuration

HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)

HyenaDNA-436K, frozen embeddings with a lightweight probe: 436K parameters; backbone frozen in inference mode, gradients disabled; embeddings standardised with training-set statistics; best readout and probe over the diagnostic test grid, chosen per task.

18 evaluations · 18 results

Overview

An explanatory profile has not yet been reviewed for this record.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

18 evaluations · 18 results. Different protocols are not a single leaderboard.

Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1) · Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)

Sorted by F1 (NT benchmark Promoter All, frozen-embedding probe) (higher is better). The best value in each column is highlighted. Decimals are rounded for display; each value links to the printed value and its source.

Tested configurationF1 (NT benchmark Promoter All, frozen-embedding probe)F1 (NT benchmark Promoter Non-TATA, frozen-embedding probe)F1 (NT benchmark Promoter TATA, frozen-embedding probe)F1 (NT benchmark Splice Acceptor, frozen-embedding probe)F1 (NT benchmark Splice All, frozen-embedding probe)F1 (NT benchmark Splice Donor, frozen-embedding probe)MCC (NT benchmark Enhancer Types, frozen-embedding probe)MCC (NT benchmark Enhancer, frozen-embedding probe)MCC (NT benchmark H3, frozen-embedding probe)MCC (NT benchmark H3K14ac, frozen-embedding probe)MCC (NT benchmark H3K36me3, frozen-embedding probe)MCC (NT benchmark H3K4me1, frozen-embedding probe)MCC (NT benchmark H3K4me2, frozen-embedding probe)MCC (NT benchmark H3K4me3, frozen-embedding probe)MCC (NT benchmark H3K79me3, frozen-embedding probe)MCC (NT benchmark H3K9ac, frozen-embedding probe)MCC (NT benchmark H4, frozen-embedding probe)MCC (NT benchmark H4ac, frozen-embedding probe)
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Evaluation0.933Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.524Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.371Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.693Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.33Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.396Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.332Not reportedNot reportedNot reportedNot reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.279Not reportedNot reportedNot reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.222Not reportedNot reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.55Not reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.43Not reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.727Not reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported0.304
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reported0.935Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reported0.934Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reported0.475Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reported0.524Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)EvaluationNot reportedNot reportedNot reportedNot reportedNot reported0.725Not reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reportedNot reported
All 18 result rows with coverage, uncertainty and sources
Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.524 MCC (NT benchmark Enhancer, frozen-embedding probe)
unitless · higher

Uncertainty: SD 0.0635

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark Enhancer (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'Enhancer', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.371 MCC (NT benchmark Enhancer Types, frozen-embedding probe)
unitless · higher

Uncertainty: SD 0.0187

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark Enhancer Types (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'Enhancer Types', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.693 MCC (NT benchmark H3, frozen-embedding probe)
unitless · higher

Uncertainty: SD 0.0158

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark H3 (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'H3', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.33 MCC (NT benchmark H3K14ac, frozen-embedding probe)
unitless · higher

Uncertainty: SD 0.0132

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark H3K14ac (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'H3K14ac', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.396 MCC (NT benchmark H3K36me3, frozen-embedding probe)
unitless · higher

Uncertainty: SD 0.0095

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark H3K36me3 (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'H3K36me3', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.332 MCC (NT benchmark H3K4me1, frozen-embedding probe)
unitless · higher

Uncertainty: SD 0.0107

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark H3K4me1 (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'H3K4me1', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.279 MCC (NT benchmark H3K4me2, frozen-embedding probe)
unitless · higher

Uncertainty: SD 0.0079

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark H3K4me2 (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'H3K4me2', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.222 MCC (NT benchmark H3K4me3, frozen-embedding probe)
unitless · higher

Uncertainty: SD 0.0100

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark H3K4me3 (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'H3K4me3', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.55 MCC (NT benchmark H3K79me3, frozen-embedding probe)
unitless · higher

Uncertainty: SD 0.0085

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark H3K79me3 (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'H3K79me3', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.43 MCC (NT benchmark H3K9ac, frozen-embedding probe)
unitless · higher

Uncertainty: SD 0.0000

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark H3K9ac (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'H3K9ac', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.727 MCC (NT benchmark H4, frozen-embedding probe)
unitless · higher

Uncertainty: SD 0.0000

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark H4 (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'H4', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.304 MCC (NT benchmark H4ac, frozen-embedding probe)
unitless · higher

Uncertainty: SD 0.0171

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark H4ac (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'H4ac', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.933 F1 (NT benchmark Promoter All, frozen-embedding probe)
fraction · higher

Uncertainty: SD 0.0004

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark Promoter All (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'Promoter All', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.935 F1 (NT benchmark Promoter Non-TATA, frozen-embedding probe)
fraction · higher

Uncertainty: SD 0.0016

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark Promoter Non-TATA (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'Promoter Non-TATA', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.934 F1 (NT benchmark Promoter TATA, frozen-embedding probe)
fraction · higher

Uncertainty: SD 0.0000

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark Promoter TATA (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'Promoter TATA', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.475 F1 (NT benchmark Splice Acceptor, frozen-embedding probe)
fraction · higher

Uncertainty: SD 0.0108

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark Splice Acceptor (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'Splice Acceptor', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.524 F1 (NT benchmark Splice All, frozen-embedding probe)
fraction · higher

Uncertainty: SD 0.0051

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark Splice All (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'Splice All', column 'HyenaDNA', frozen value
Configuration: HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026)Protocol: Nucleotide Transformer benchmark under frozen-embedding probing (Datta et al. 2026 Table 1)
Dataset: Nucleotide Transformer benchmark task data (Datta et al. 2026)
0.725 F1 (NT benchmark Splice Donor, frozen-embedding probe)
fraction · higher

Uncertainty: SD 0.0087

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-436K on NT benchmark Splice Donor (frozen probe)

gfm2-20261011-datta2026-protocol-frozen-probe

Aggregation: Not reported

Frozen but Not Always Accessible: A Representation Analysis of Genomic Language Models · Table 1, row 'Splice Donor', column 'HyenaDNA', frozen value

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Evidence table

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

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Technical metadata and extraction receipts

Stable ID: gfm2-20261011-datta2026-config-hyenadna-frozen

areas
dna-genomes
contexts
research
method types
foundation_model
reported name
HyenaDNA-436K
foundation model eligible
true
source locator
Section 2.2 model list; Table 1 column 'HyenaDNA'
parameters
436K parameters; backbone frozen in inference mode, gradients disabled; embeddings standardised with training-set statistics; best readout and probe over the diagnostic test grid, chosen per task (Table 3)
missing metadata
version: reason: unreported; note: Parameter count printed; no checkpoint revision or release version is given
training setting
Frozen backbone, probe only
provenance note
HyenaDNA-436K, frozen embeddings with a lightweight probe (Datta et al. 2026), as evaluated in the cited comparison.
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