Ensemble scCello + UCE (Wu et al. 2025)
Ensemble of OnClass classifiers: scCello + UCE.
Overview
Ensemble of OnClass classifiers: scCello + UCE.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Evaluations and results
2 evaluations · 4 results. Different protocols are not a single leaderboard.
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| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Ensemble scCello + UCE (Wu et al. 2025) | Protocol: Cross-atlas annotation transfer, HLCA to Tabula Sapiens, 14 shared cell types (Wu et al. 2025 Table S3) Dataset: Tabula Sapiens (CELLxGENE), 120 leaf cell types after processing | 0.852 top-1-accuracy fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceUCE + scCello: HLCA to Tabula Sapiens transfer (Wu et al. 2025) cell-type-20261009-protocol-wu2025-hlca-to-ts Aggregation: Not reported Wu et al. 2025, Additional file 3 (Supplementary Tables S1-S13) · Table S3, cell B25, row 'UCE + scCello', column 'Accuracy@1' |
| Configuration: Ensemble scCello + UCE (Wu et al. 2025) | Protocol: Cross-atlas annotation transfer, HLCA to Tabula Sapiens, 14 shared cell types (Wu et al. 2025 Table S3) Dataset: Tabula Sapiens (CELLxGENE), 120 leaf cell types after processing | 0.303 macro-f1 fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceUCE + scCello: HLCA to Tabula Sapiens transfer (Wu et al. 2025) cell-type-20261009-protocol-wu2025-hlca-to-ts Aggregation: Not reported Wu et al. 2025, Additional file 3 (Supplementary Tables S1-S13) · Table S3, cell C25, row 'UCE + scCello', column 'Macro-F1' |
| Configuration: Ensemble scCello + UCE (Wu et al. 2025) | Protocol: Cross-atlas annotation transfer, Tabula Sapiens to HLCA, 14 shared cell types (Wu et al. 2025 Table S2) Dataset: HLCA core (CELLxGENE), 37 leaf cell types after processing | 0.736 top-1-accuracy fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceUCE + scCello: Tabula Sapiens to HLCA transfer (Wu et al. 2025) cell-type-20261009-protocol-wu2025-ts-to-hlca Aggregation: Not reported Wu et al. 2025, Additional file 3 (Supplementary Tables S1-S13) · Table S2, cell B18, row 'UCE + scCello', column 'Accuracy@1' |
| Configuration: Ensemble scCello + UCE (Wu et al. 2025) | Protocol: Cross-atlas annotation transfer, Tabula Sapiens to HLCA, 14 shared cell types (Wu et al. 2025 Table S2) Dataset: HLCA core (CELLxGENE), 37 leaf cell types after processing | 0.126 macro-f1 fraction · higher Uncertainty: Not reported by the source Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceUCE + scCello: Tabula Sapiens to HLCA transfer (Wu et al. 2025) cell-type-20261009-protocol-wu2025-ts-to-hlca Aggregation: Not reported Wu et al. 2025, Additional file 3 (Supplementary Tables S1-S13) · Table S2, cell C18, row 'UCE + scCello', column 'Macro-F1' |
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Evidence
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Evidence table
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Sources and history
Release 2026-10-10-6e93f504adfc · Record review: source checked
2 source records and release history
- Biology-driven insights into the power of single-cell foundation models · Original source · Genome Biology 26:334, published 2025-10-03; PMC12492631 full-text XML
- Wu et al. 2025, Additional file 3 (Supplementary Tables S1-S13) · Original source · 13059_2025_3781_MOESM3_ESM.xlsx (38,926 bytes), as linked from the article XML <supplementary-material id="MOESM3">
Technical metadata and extraction receipts
Stable ID: cell-type-20261009-config-wu2025-ensemble-sccello-uce
- areas
- cells-tissues
- contexts
- research
- method types
- foundation_model
- reported name
- scCello + UCE
- source locator
- Supplementary Tables S2-S3 column 'Model' Results 'Cross-dataset validation' paragraphs 3-4
- foundation model eligible
- true
- parameters
- Sum of the output logits of the scCello and UCE OnClass classifiers, then softmax
- missing metadata
- version: reason: inapplicable; note: An ensemble of the listed configurations
Related records
- configuration of: Ensemble of scFM embedding classifiers
- uses model: scCello
- uses model: UCE (Universal Cell Embeddings)
- system: UCE + scCello: HLCA to Tabula Sapiens transfer (Wu et al. 2025)
- system: UCE + scCello: Tabula Sapiens to HLCA transfer (Wu et al. 2025)