rewirebio.iobenchmarks
Configuration

HyenaDNA-450K, long sequence (pathogenic/common SNP classification)

HyenaDNA-450K, long sequence (pathogenic/common SNP classification); Feng et al. 2025 source-reported, task-scoped configuration.

1 evaluation · 2 results

Overview

HyenaDNA-450K, long sequence (pathogenic/common SNP classification); Feng et al. 2025 source-reported, task-scoped configuration.

Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.

Evaluations and results

1 evaluation · 2 results. Different protocols are not a single leaderboard.

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Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: HyenaDNA-450K, long sequence (pathogenic/common SNP classification)Protocol: Feng pathogenic-versus-common SNP classification
Dataset: Feng pathogenic/common SNP long-window dataset
0.626 pathogenic/common SNP AUC
AUC · higher

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-450K, long sequence pathogenic/common SNP evaluation

Table 5, frozen embeddings + random forest classifier

Aggregation: Not reported

Benchmarking DNA foundation models for genomic and genetic tasks · Table 5, HyenaDNA-450K, long sequence row, AUC column (deterministic XML extraction)
Configuration: HyenaDNA-450K, long sequence (pathogenic/common SNP classification)Protocol: Feng pathogenic-versus-common SNP classification
Dataset: Feng pathogenic/common SNP long-window dataset
0.449 pathogenic/common SNP Cohen's d
Cohen's d · unknown

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Independent external evaluation · Source checked
Methods, coverage and source

HyenaDNA-450K, long sequence pathogenic/common SNP evaluation

Table 5, frozen embeddings + random forest classifier

Aggregation: Not reported

Benchmarking DNA foundation models for genomic and genetic tasks · Table 5, HyenaDNA-450K, long sequence row, Cohen's d column (deterministic XML extraction). Signed effect size; the source does not state a universal desirable sign/direction, so direction is recorded as unknown rather than assumed higher-is-better.

Source checking is not independent reproduction. Release 2026-10-07-1448159e6a81.

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Evidence

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Claims, original sources and review scope · Release 2026-10-07-1448159e6a81
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Release 2026-10-07-1448159e6a81 · Record review: source checked

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Technical metadata and extraction receipts

Stable ID: amp-feng-20261007-config-variant-hyenadna-450k-long-sequence

method types
foundation_model
actual input bp
Not reported
foundation model eligible
true
head
Supervised random forest fitted separately for this task
head revision
Not reported
missing metadata
version: Printed model name and input representation only; immutable checkpoint/head revision is unreported in the inspected primary text.
output aggregation bp
Not reported
reported name
HyenaDNA-450K, long sequence
representation
Alternate-minus-reference frozen representation
task
pathogenic/common SNP classification
version
Not reported
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