Configuration

DELFI 2019 internally cross-validated cancer detection tested configuration

DELFI 2019 internally cross-validated cancer detection tested configuration; bounded primary-source candidate.

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DELFI 2019 internally cross-validated cancer detection tested configuration; bounded primary-source candidate.

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Tested configuration	Protocol and dataset	Finding	Evidence and details
Configuration: DELFI 2019 internally cross-validated cancer detection tested configuration	Protocol: DELFI 2019 internally cross-validated cancer detection protocol Dataset: DELFI 2019 internally cross-validated cancer detection cohort	73% sensitivity_at_reported_98_percent_specificity percent · higher Uncertainty: 95% CI 67%–79%; sensitivity intervals from 2,000 bootstrap replicates Coverage: Not reported scored / Not reported eligible	Author-reported evaluation · Source checked Methods, coverage and source DELFI 2019 internally cross-validated cancer detection amp-20261007-ctdna-fragmentomics-protocol Aggregation: Not reported Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 · PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11.

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Release 2026-10-07-1448159e6a81 · Record review: source checked

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Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 · Original source · Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252

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Technical metadata and extraction receipts

Stable ID: amp-20261007-ctdna-fragmentomics-configuration

areas: dna-genomes
method types: supervised_machine_learning
tasks: cancer_detection
foundation model eligible: false
missing metadata: version: Source workflow described; immutable executable version not fully pinned
reported name: DELFI stochastic gradient boosting: GC-corrected TOTAL and SHORT fragment coverage in 504 genomic bins, 39 autosomal arm Z-scores and mitochondrial representation. R gbm 2.1-4, n.trees=150, interaction.depth=3, shrinkage=0.1, n.minobsinside=10.
version: Not reported

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configuration: DELFI 2019 internally cross-validated cancer detection

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