Evidence claim

Relevance of Acute leukaemia whole RNA-seq against conventional diagnostics (Kim et al. 2026) to "Select a tumour RNA fusion-detection workflow"

Use case: Select a tumour RNA fusion-detection workflow
Assessed by: Acute leukaemia whole RNA-seq fusion detection against conventional diagnostics (Kim et al. 2026)
Relevance: Direct evidence
Endpoint: Sensitivity, 1 - specificity and concordance of an Arriba-based whole RNA-seq workflow with manual review against karyotyping, FISH and RT-PCR, overall, by subtype and per fusion

Real patient specimens scored against orthogonal clinical assays, not against the workflow's own calls, measure the sensitivity the use case asks about without the ascertainment bias the use case names as a gap; only one workflow is evaluated.

1 reviewed evaluation

Arriba v2.4.0 with IGV review against conventional diagnostics in 101 acute leukaemia patients (Kim et al. 2026)

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

17 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Citation locations 1 values source id rna-fusion-leukaemia-20261011-source-kim2025 locator Methods 'RNA-seq and fusion gene detection', 'Statistical analysis'; Table 2; Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods'; Discussion paragraphs 2-3 Context-only references	Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia Original source ↗ rna-fusion-leukaemia-20261011-source-kim2025: Methods 'RNA-seq and fusion gene detection', 'Statistical analysis'; Table 2; Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods'; Discussion paragraphs 2-3 Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML Retrieved: 2026-10-11T21:37:42Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.citation_locators` Source artifact SHA-256: `4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Comparison group kim2025-leukaemia Context-only references	Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia Original source ↗ rna-fusion-leukaemia-20261011-source-kim2025: Methods 'RNA-seq and fusion gene detection', 'Statistical analysis'; Table 2; Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods'; Discussion paragraphs 2-3 Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML Retrieved: 2026-10-11T21:37:42Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.comparison_group` Source artifact SHA-256: `4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Constraints 2 values Inspect every linked evaluation's source locator before citing a result. Do not combine this mapping's evaluations with any other protocol's results; truth sets, specimens, sequencing and caller versions differ between sources. Context-only references	Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia Original source ↗ rna-fusion-leukaemia-20261011-source-kim2025: Methods 'RNA-seq and fusion gene detection', 'Statistical analysis'; Table 2; Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods'; Discussion paragraphs 2-3 Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML Retrieved: 2026-10-11T21:37:42Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.constraints` Source artifact SHA-256: `4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Endpoint Sensitivity, 1 - specificity and concordance of an Arriba-based whole RNA-seq workflow with manual review against karyotyping, FISH and RT-PCR, overall, by subtype and per fusion Context-only references	Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia Original source ↗ rna-fusion-leukaemia-20261011-source-kim2025: Methods 'RNA-seq and fusion gene detection', 'Statistical analysis'; Table 2; Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods'; Discussion paragraphs 2-3 Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML Retrieved: 2026-10-11T21:37:42Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.endpoint` Source artifact SHA-256: `4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Claimed field links:assessed_by:rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics Context-only references	Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia Original source ↗ rna-fusion-leukaemia-20261011-source-kim2025: Methods 'RNA-seq and fusion gene detection', 'Statistical analysis'; Table 2; Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods'; Discussion paragraphs 2-3 Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML Retrieved: 2026-10-11T21:37:42Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.field` Source artifact SHA-256: `4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Headline metric recall Context-only references	Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia Original source ↗ rna-fusion-leukaemia-20261011-source-kim2025: Methods 'RNA-seq and fusion gene detection', 'Statistical analysis'; Table 2; Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods'; Discussion paragraphs 2-3 Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML Retrieved: 2026-10-11T21:37:42Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.headline_metric` Source artifact SHA-256: `4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Limitations 6 values One workflow (Arriba with manual review) compared with conventional diagnostics; no other caller is evaluated, so this is not a caller comparison. Truth is conventional diagnostics (karyotyping, FISH, multiplex RT-PCR), which miss some fusions: the 12 RNA-seq-only fusions count against specificity, although the authors describe several as well-known recurrent fusions and confirmed one of them (MLLT10::UBE2L6) by RT-PCR and Sanger sequencing (Figure 1); validation was attempted only for novel or rare fusions with residual sample. Missed fusions are attributed by the authors to low blast proportion, subclonality, poor aspirates, complex rearrangements or enhancer hijacking, not to the caller alone. Single centre, acute leukaemia only (adult and paediatric); 48 conventional-positive fusions; no interval estimates. Every call was manually reviewed in IGV, so the false-call burden of raw Arriba output is not measured. Per-patient results (Supplemental Data Tables S2 and S3) and Supplemental Figure S1 were not retrieved; the AML (86.4%) and B-ALL (87.0%) sensitivities are printed only in the Discussion, without denominators. Context-only references	Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia Original source ↗ rna-fusion-leukaemia-20261011-source-kim2025: Methods 'RNA-seq and fusion gene detection', 'Statistical analysis'; Table 2; Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods'; Discussion paragraphs 2-3 Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML Retrieved: 2026-10-11T21:37:42Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.limitations` Source artifact SHA-256: `4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Pinned records 87 values record id rna-fusion-leukaemia-20261011-eval-arriba-conventional-diagnostics fields status links attributes.origin attributes.comparison sha256 82ece08c7eb52f6b9e5aa5fc7a62d9302ac1034aec7bf64040a9efec1613d235 record id rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics fields status name description facets source_ids links attributes sha256 9b5faf78e0d0eddfca84dfed530ad646f04678f9697bc28f11c81c6a2adc6710 record id rna-fusion-leukaemia-20261011-result-arriba-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 1adda6006c98967ffae3adfff54c8b02121f92b92740fbee4032c4130db7edc6 record id rna-fusion-leukaemia-20261011-result-arriba-one-minus-specificity fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 dcb56d9501795bcb8a851cd8cf08155093f428bac3e07433985149965e62f6d2 record id rna-fusion-leukaemia-20261011-result-arriba-sensitivity fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 e6d74372b735b4f0a95b804fc50a098e577f6e96b4c8cae03f9c20baa2b85a97 record id rna-fusion-leukaemia-20261011-result-arriba-sensitivity-aml fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 aa17da8e44d0a5fdb63ed01af49cd8a970e5f5439eb1f3ee4f984eb59e473c88 record id rna-fusion-leukaemia-20261011-result-arriba-sensitivity-b-all fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 2dbdcd85eb01d8078f8fc4a4509dfb022010fab93fff6865beefa8b91427ae30 record id rna-fusion-leukaemia-20261011-result-bcr-abl1-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 77cca185c44bf6db4ebf6b17f3b230931fbc95b77445ef38649da358e31236a5 record id rna-fusion-leukaemia-20261011-result-bcr-abl1-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 e966a63dc02f937476d7ce2550cbe6aadae187c0354461c73c0b0d9ed0bbbe41 record id rna-fusion-leukaemia-20261011-result-bcr-abl1-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 7ad9c71479fee4f424ffea339670acf9110b6b075c065d1947b82a668398511b record id rna-fusion-leukaemia-20261011-result-cbfb-myh11-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 40fb1ace7b6a920be80b1ef93fb63136ffef79941759c1787fd0646d0ddf541c record id rna-fusion-leukaemia-20261011-result-cbfb-myh11-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 ec95149db4ff7fbd3322d5e575b584c1b044357780ed32558e38f19d88d76481 record id rna-fusion-leukaemia-20261011-result-cbfb-myh11-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 4dda324bdb09448d17263e4d5cf04dd6d1ae7bd6c0a4a40608b4b2e2cf668542 record id rna-fusion-leukaemia-20261011-result-dek-nup214-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 e1ef9389de81d4bd27a7919b08e44f48e0a722785148b4a32e2245c365478e6a record id rna-fusion-leukaemia-20261011-result-dek-nup214-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 1d52d91d9ebf42c5dd088cca92088114aeaa2a7b12b536c1ecf72a770c0ead33 record id rna-fusion-leukaemia-20261011-result-dek-nup214-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 4b7f6b00f3a0c1763166876a668a03a39456aaadd9f9975569abc7fc36ea7f1f record id rna-fusion-leukaemia-20261011-result-etv6-ncoa2-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 faea26ad87db312119a83755bc8883b1bc1f5efbc3ff193f9752bcb70e6dcf53 record id rna-fusion-leukaemia-20261011-result-etv6-ncoa2-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 dcecc337c03e9d19c65bbc0c1900cc36865c2c1cd9d6c6cc5b18d25ffd7fdc30 record id rna-fusion-leukaemia-20261011-result-etv6-ncoa2-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 f53f010629918b3ba352704cce57bf1701cc75f1187d4ab8295f43c3ba97c296 record id rna-fusion-leukaemia-20261011-result-etv6-runx1-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 396a21d0b06d10276fb9bf0b85f2cbd8bf8197087fa9813303f1917b3918da03 record id rna-fusion-leukaemia-20261011-result-etv6-runx1-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 80fd0466324f015ac8e0f356ceb52c47a7bc7b5d4812d3cc2149fc47bf868205 record id rna-fusion-leukaemia-20261011-result-etv6-runx1-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 df821084b00df10086612324748be82f9eb8d67b9136f8189b8254e5df6f0916 record id rna-fusion-leukaemia-20261011-result-fus-znf362-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 34f1797cfea502f860817bd1be5015020e48fad44158d3be2a6d065081667008 record id rna-fusion-leukaemia-20261011-result-fus-znf362-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 5ec837d1e63c5405b8d6d0b0ff25456cad2cd24321e567d78015ce92957b7c77 record id rna-fusion-leukaemia-20261011-result-fus-znf362-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 3cc049edfc0d7b405409e2d16f93b1085a01057ddb9196018cc4921020eb55c9 record id rna-fusion-leukaemia-20261011-result-hnrnph1-erg-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 c3b916c124c42603f99279ae166874615978d3210ad66239ca83f782d0c6da39 record id rna-fusion-leukaemia-20261011-result-hnrnph1-erg-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 00e0c2b0001c4065b5de1700552a14dcf557b8db18197af370922de50f71885c record id rna-fusion-leukaemia-20261011-result-hnrnph1-erg-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 60fe8d5e8037c8f6715701fac1d5e9dba9d8b64f57792b311da55c1b9ac4544d record id rna-fusion-leukaemia-20261011-result-igh-cebpa-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 79e884618f5be5c1351245db20f8db8dc3e2cc75f387b03b0235672c4fe16104 record id rna-fusion-leukaemia-20261011-result-igh-cebpa-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 e64f0ee7ab3a5f1063aac81740adfc3bf50bceb6c9e7f33cd866090b7c4cdd4c record id rna-fusion-leukaemia-20261011-result-igh-cebpa-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 b4f99c1fbad590cb29dd431325b4b0545a732406c4df39c8cdb3cfcae9e1c4b3 record id rna-fusion-leukaemia-20261011-result-igh-crlf2-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 3ac52009ce4c5f68a41824886dc9732bcd101992fd533d951aaff83386a00c60 record id rna-fusion-leukaemia-20261011-result-igh-crlf2-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 da65bd899e72651547f580245ef8a5de330ce7287e32c1d8efcd3c3cdaa1a954 record id rna-fusion-leukaemia-20261011-result-igh-crlf2-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 028dc2f6d9bc571a9a47204bf4633f05336f90de3a1525d68bfab8dac7055733 record id rna-fusion-leukaemia-20261011-result-kmt2a-ell-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 cad675649b8799247ba0331ddf461c4ec155be506c20d8207cc431b0c19576d0 record id rna-fusion-leukaemia-20261011-result-kmt2a-ell-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 d18e2e9116c8841406c4b94f28843dacf223ec3fc93ded7b12bb29871ea9d721 record id rna-fusion-leukaemia-20261011-result-kmt2a-ell-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 e6d79677d0b9741cd4d5cf463841ba3ad36a8e9b7dfc29641b246999cf7ce8cf record id rna-fusion-leukaemia-20261011-result-kmt2a-mllt10-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 e01f739114441e6bb48e929bdc68b89712b4c72af2f40866ad3a512d6c5f6327 record id rna-fusion-leukaemia-20261011-result-kmt2a-mllt10-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 a07b6abdda4f757df4d4472f8e1dc04066f3dc3da007d2f73c31bfacbe54746c record id rna-fusion-leukaemia-20261011-result-kmt2a-mllt10-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 dc65d5d8a49b027c248442d590169c97bf220f2bcffb24cda47a0007b43c6863 record id rna-fusion-leukaemia-20261011-result-kmt2a-mllt3-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 58aad0641e21512a8b17cf9160fa623d5181a5c6cf3df755aea4698bc99492c4 record id rna-fusion-leukaemia-20261011-result-kmt2a-mllt3-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 dd97c73475a252df372bb66e9c12471e9775c69a9373eccd5d0f4de10a16fc4a record id rna-fusion-leukaemia-20261011-result-kmt2a-mllt3-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 638d96109417861edd70a9974abd36cd5d8ca873837914ef47b2428e0d94dcd2 record id rna-fusion-leukaemia-20261011-result-kmt2a-unspecified-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 a247bb69007271277a19b1495a2a93ecb1975a4c568449de49be78128d79e96b record id rna-fusion-leukaemia-20261011-result-kmt2a-unspecified-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 5e26a4a4c50853aafde1ba31dde5805094c3d31beec5051aa247ed67a97e7b78 record id rna-fusion-leukaemia-20261011-result-kmt2a-unspecified-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 57a95ecffd9b016d750c6ae3b9009ad7e7e75c5fbf86c072d92ee0fcb3c889da record id rna-fusion-leukaemia-20261011-result-mecom-unspecified-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 75b86e3f951c0e577df81a84289b90798de9362881d983f908802406de6d7883 record id rna-fusion-leukaemia-20261011-result-mecom-unspecified-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 30aea258d6ca8901288844d8ce7026a8187f6dc318635073f6625ddb587877dc record id rna-fusion-leukaemia-20261011-result-mecom-unspecified-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 6d478d919d6101c0fb73b11897bd378d056542555117449df5869b0d80ec56f4 record id rna-fusion-leukaemia-20261011-result-mllt10-ube2l6-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 b6cb809051bb8430faf5a17a7fb2f31fdbb4933ce48576c3e94c86db530b9b5e record id rna-fusion-leukaemia-20261011-result-mllt10-ube2l6-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 0796d117ee9252c1465739151f3594c207312fd0455fc3ac1c0b7a8546c85da6 record id rna-fusion-leukaemia-20261011-result-mllt10-ube2l6-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 8c60f009b7640641948fd465edd99be5b5af9277501eea90b4d76907e7a31238 record id rna-fusion-leukaemia-20261011-result-p2ry8-crlf2-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 b5b7ac017dab57a6804d31b25a6ddb56ec67812cb3eabda53d6ac3fc559c813a record id rna-fusion-leukaemia-20261011-result-p2ry8-crlf2-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 67e8a934ef65455fce9f1593e642babad7d901dfad984f2b96486ea8728f94b1 record id rna-fusion-leukaemia-20261011-result-p2ry8-crlf2-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 4d4038525c63c312021dfbedb190d7002dc1e6a22fd9dce45e7f16d86b0468ff record id rna-fusion-leukaemia-20261011-result-pax5-jak2-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 48893c0bd87c3dd568281cbfae16c6abe1df780eca679da0e79fc27fa3a457d4 record id rna-fusion-leukaemia-20261011-result-pax5-jak2-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 b395efd73adae4d9ea02ca25d23bdf2d15362186c974491a94f69303a16e391c record id rna-fusion-leukaemia-20261011-result-pax5-jak2-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 59079578713256e2ebdc993141d79dd77336699b047a3e534df624287538ffb2 record id rna-fusion-leukaemia-20261011-result-pax5-nol4l-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 9f10dbebe24ef854f95ecd07c8229e462b5bc6b47626ddee0dd2208c7d47d7ca record id rna-fusion-leukaemia-20261011-result-pax5-nol4l-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 2fbbe8023b7aad4c668657c3c930cd7357bd3cce3675d65b9fbdc352072bea72 record id rna-fusion-leukaemia-20261011-result-pax5-nol4l-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 bd964818278a02f1fa46f251c52a81b5a74df1d91aafbcf98d43b1d055a82d12 record id rna-fusion-leukaemia-20261011-result-picalm-mllt10-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 14913c5e738d2017112a81ea56ae4f67c6858e5e981bfe10691e6cfe858030cd record id rna-fusion-leukaemia-20261011-result-picalm-mllt10-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 1b28dd60a4c8ae4174fbb76ae3ac288b45c3ceeb4b59ba2443917f925c165d18 record id rna-fusion-leukaemia-20261011-result-picalm-mllt10-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 b1213bfd4dd00f4dc6b1e0a26c3f84cd6a322ee6f098bba82ec3d08bacef7ba3 record id rna-fusion-leukaemia-20261011-result-pml-rara-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 3d3bcb85c93f51d029612a32003f1c499b28857e4cc4a7f85b369c0fcb84fb73 record id rna-fusion-leukaemia-20261011-result-pml-rara-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 6f1617150330e59b9cde29c28ebabfb88aebe409fd31a2f0d3a1badf267b6af5 record id rna-fusion-leukaemia-20261011-result-pml-rara-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 adff097f51f01ff37506ea6f18337594d7f0cebef390821bda6c605d47b38c49 record id rna-fusion-leukaemia-20261011-result-runx1-runx1t1-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 cff3f7e5bd7fe63760975bf478991905684d0867459d3e51ffcc74a578809f62 record id rna-fusion-leukaemia-20261011-result-runx1-runx1t1-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 7b24aff3b0d8bee5c51f3e02b331fe0a0b29b9af37f9dd1cbc3b925243ae08ee record id rna-fusion-leukaemia-20261011-result-runx1-runx1t1-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 c848c2ebbd482f675200499cfb5c3a2ecb5446219bf01f3bc2e2e7177c5454f1 record id rna-fusion-leukaemia-20261011-result-runx1-unspecified-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 f7cb101a9b27cd53273fc412f3552b3d2407d431569bdab1f0906ad304200306 record id rna-fusion-leukaemia-20261011-result-runx1-unspecified-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 ec9da5f2111f190980520c86645bed1cb7cdcca9f45cf6dd1005954add08e46c record id rna-fusion-leukaemia-20261011-result-runx1-unspecified-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 79030520e66b420ac327bb8150fa43a370314de3a34d8a5791eb0a6de5296433 record id rna-fusion-leukaemia-20261011-result-runx1-usp42-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 6d9e887a0b3dc7de97ef2c21946151175110aa07a79323edc47b5dea5d418ab6 record id rna-fusion-leukaemia-20261011-result-runx1-usp42-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 efc804ed0de5bed351f9a01dbca5bd914f8d9e4a74a4ba59cc59378a82a23b35 record id rna-fusion-leukaemia-20261011-result-runx1-usp42-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 ee0a9a0548ce4b0b3dd6e42e7bfa1b80165eafa59d021d1eac2262925e1a5b79 record id rna-fusion-leukaemia-20261011-result-stil-tal1-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 b1e9512f006665e12611f31599166903d7d64214093eb52578c1efba3b82b0c2 record id rna-fusion-leukaemia-20261011-result-stil-tal1-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 57ff359197866e49d439f6c956dea59ae4af560c298d126604cf0dee9fe322dd record id rna-fusion-leukaemia-20261011-result-stil-tal1-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 ed858a1b77848e97621fb041768a216fa8f5079b524ad54375fa61df6bafbe27 record id rna-fusion-leukaemia-20261011-result-tcf3-hlf-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 4c9e0d9cc3ae38e84a113647565bb38ecaf54543ac8e8ff8740623d292433239 record id rna-fusion-leukaemia-20261011-result-tcf3-hlf-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 16c9b92cad55c558d41b95cbecf4843eec72bc9866fc672a8a83e5bb9e63d794 record id rna-fusion-leukaemia-20261011-result-tcf3-hlf-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 9dd7d226bc707a74cbcab6ccc655b9ff434f07438069ce698f1804480bebdaf0 record id rna-fusion-leukaemia-20261011-result-tra-d-unspecified-concordance fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 e06ad950197ebd8adefb859296643572694c898dbfda0841540c7c4cd01e0f49 record id rna-fusion-leukaemia-20261011-result-tra-d-unspecified-conv fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 239b3f43900ceda9f1facf5aa1e9d0298a0730f6efe086c71a0f85530cf626ef record id rna-fusion-leukaemia-20261011-result-tra-d-unspecified-rnaseq fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 e7dd0be825cfd8e703c11ccb85878e06afe7c2bb5fccdd5257aea93f8ec9dff5 record id rna-fusion-leukaemia-20261011-source-kim2025 fields status attributes.artifact_sha256 sha256 660a9e63a81ee2560f3f48fa4e091bd1a305f681d835f212b52b41f599ad7fb6 record id use-case-tumour-rna-fusion-detection fields status name description facets attributes.question attributes.decision attributes.inputs attributes.output attributes.exclusions attributes.setting attributes.clinical_scope attributes.intended_users sha256 813ef5e1275c5b78b486810d5445b67c9069bf366d78399aa2098727d56b2d15 Context-only references	Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia Original source ↗ rna-fusion-leukaemia-20261011-source-kim2025: Methods 'RNA-seq and fusion gene detection', 'Statistical analysis'; Table 2; Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods'; Discussion paragraphs 2-3 Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML Retrieved: 2026-10-11T21:37:42Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.pins` Source artifact SHA-256: `4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Rationale Real patient specimens scored against orthogonal clinical assays, not against the workflow's own calls, measure the sensitivity the use case asks about without the ascertainment bias the use case names as a gap; only one workflow is evaluated. Context-only references	Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia Original source ↗ rna-fusion-leukaemia-20261011-source-kim2025: Methods 'RNA-seq and fusion gene detection', 'Statistical analysis'; Table 2; Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods'; Discussion paragraphs 2-3 Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML Retrieved: 2026-10-11T21:37:42Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.rationale` Source artifact SHA-256: `4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Reason Add a relevance judgement from the 2026-10-11 oncology use-case literature pass. Context-only references	Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia Original source ↗ rna-fusion-leukaemia-20261011-source-kim2025: Methods 'RNA-seq and fusion gene detection', 'Statistical analysis'; Table 2; Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods'; Discussion paragraphs 2-3 Version: Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML Retrieved: 2026-10-11T21:37:42Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.reason` Source artifact SHA-256: `4d3a6d48fc107763bffe18ff7dbcb6ab97b86757e69ff89ae595f3243f30bad1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia · Original source · Annals of Laboratory Medicine 46(3), epub 2025-10-16; PMC13071280 full-text XML

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: use-case-mapping-rna-fusion-leukaemia-20261011-conventional-diagnostics

field: links:assessed_by:rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics
value: rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics
relevance: direct
endpoint: Sensitivity, 1 - specificity and concordance of an Arriba-based whole RNA-seq workflow with manual review against karyotyping, FISH and RT-PCR, overall, by subtype and per fusion
rationale: Real patient specimens scored against orthogonal clinical assays, not against the workflow's own calls, measure the sensitivity the use case asks about without the ascertainment bias the use case names as a gap; only one workflow is evaluated.
constraints: Inspect every linked evaluation's source locator before citing a result.; Do not combine this mapping's evaluations with any other protocol's results; truth sets, specimens, sequencing and caller versions differ between sources.
limitations: One workflow (Arriba with manual review) compared with conventional diagnostics; no other caller is evaluated, so this is not a caller comparison.; Truth is conventional diagnostics (karyotyping, FISH, multiplex RT-PCR), which miss some fusions: the 12 RNA-seq-only fusions count against specificity, although the authors describe several as well-known recurrent fusions and confirmed one of them (MLLT10::UBE2L6) by RT-PCR and Sanger sequencing (Figure 1); validation was attempted only for novel or rare fusions with residual sample.; Missed fusions are attributed by the authors to low blast proportion, subclonality, poor aspirates, complex rearrangements or enhancer hijacking, not to the caller alone.; Single centre, acute leukaemia only (adult and paediatric); 48 conventional-positive fusions; no interval estimates.; Every call was manually reviewed in IGV, so the false-call burden of raw Arriba output is not measured.; Per-patient results (Supplemental Data Tables S2 and S3) and Supplemental Figure S1 were not retrieved; the AML (86.4%) and B-ALL (87.0%) sensitivities are printed only in the Discussion, without denominators.
citation locators: source id: rna-fusion-leukaemia-20261011-source-kim2025; locator: Methods 'RNA-seq and fusion gene detection', 'Statistical analysis'; Table 2; Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods'; Discussion paragraphs 2-3
source locator: rna-fusion-leukaemia-20261011-source-kim2025: Methods 'RNA-seq and fusion gene detection', 'Statistical analysis'; Table 2; Results 'Fusion gene detection performance of RNA-seq compared with that of conventional diagnostic methods'; Discussion paragraphs 2-3
headline metric: recall
reason: Add a relevance judgement from the 2026-10-11 oncology use-case literature pass.
comparison group: kim2025-leukaemia
comparison title: Arriba whole RNA-seq against conventional diagnostics in acute leukaemia (Kim et al. 2026)
stratum label: Acute leukaemia, 101 patients
stratum order: 1
reviewed evaluations: rna-fusion-leukaemia-20261011-eval-arriba-conventional-diagnostics
review: method: ai-assisted-source-review; scope-review; method note: Reviewer checked the endpoint against the use case's inputs and output, the relevance rating and the limitations; every evaluation on the protocol had its values checked in the batch review. Corrections listed in review.md were applied by the extractor.; reviewer: claude; reviewer note: Claude research agent reviewer-onc-2, independent of the extractor uc-oncology; no human review claimed; reviewed at: 2026-10-11T23:30:00Z; note: Automated review; not human scientific review. See docs/reviews/use-cases/tumour-rna-fusion-detection-2026-10-11.md.
pins: record id: rna-fusion-leukaemia-20261011-eval-arriba-conventional-diagnostics; fields: status; links; attributes.origin; attributes.comparison; sha256: 82ece08c7eb52f6b9e5aa5fc7a62d9302ac1034aec7bf64040a9efec1613d235; record id: rna-fusion-leukaemia-20261011-protocol-conventional-diagnostics; fields: status; name; description; facets; source_ids; links; attributes; sha256: 9b5faf78e0d0eddfca84dfed530ad646f04678f9697bc28f11c81c6a2adc6710; record id: rna-fusion-leukaemia-20261011-result-arriba-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 1adda6006c98967ffae3adfff54c8b02121f92b92740fbee4032c4130db7edc6; record id: rna-fusion-leukaemia-20261011-result-arriba-one-minus-specificity; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: dcb56d9501795bcb8a851cd8cf08155093f428bac3e07433985149965e62f6d2; record id: rna-fusion-leukaemia-20261011-result-arriba-sensitivity; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: e6d74372b735b4f0a95b804fc50a098e577f6e96b4c8cae03f9c20baa2b85a97; record id: rna-fusion-leukaemia-20261011-result-arriba-sensitivity-aml; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: aa17da8e44d0a5fdb63ed01af49cd8a970e5f5439eb1f3ee4f984eb59e473c88; record id: rna-fusion-leukaemia-20261011-result-arriba-sensitivity-b-all; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 2dbdcd85eb01d8078f8fc4a4509dfb022010fab93fff6865beefa8b91427ae30; record id: rna-fusion-leukaemia-20261011-result-bcr-abl1-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 77cca185c44bf6db4ebf6b17f3b230931fbc95b77445ef38649da358e31236a5; record id: rna-fusion-leukaemia-20261011-result-bcr-abl1-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: e966a63dc02f937476d7ce2550cbe6aadae187c0354461c73c0b0d9ed0bbbe41; record id: rna-fusion-leukaemia-20261011-result-bcr-abl1-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 7ad9c71479fee4f424ffea339670acf9110b6b075c065d1947b82a668398511b; record id: rna-fusion-leukaemia-20261011-result-cbfb-myh11-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 40fb1ace7b6a920be80b1ef93fb63136ffef79941759c1787fd0646d0ddf541c; record id: rna-fusion-leukaemia-20261011-result-cbfb-myh11-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: ec95149db4ff7fbd3322d5e575b584c1b044357780ed32558e38f19d88d76481; record id: rna-fusion-leukaemia-20261011-result-cbfb-myh11-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 4dda324bdb09448d17263e4d5cf04dd6d1ae7bd6c0a4a40608b4b2e2cf668542; record id: rna-fusion-leukaemia-20261011-result-dek-nup214-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: e1ef9389de81d4bd27a7919b08e44f48e0a722785148b4a32e2245c365478e6a; record id: rna-fusion-leukaemia-20261011-result-dek-nup214-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 1d52d91d9ebf42c5dd088cca92088114aeaa2a7b12b536c1ecf72a770c0ead33; record id: rna-fusion-leukaemia-20261011-result-dek-nup214-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 4b7f6b00f3a0c1763166876a668a03a39456aaadd9f9975569abc7fc36ea7f1f; record id: rna-fusion-leukaemia-20261011-result-etv6-ncoa2-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: faea26ad87db312119a83755bc8883b1bc1f5efbc3ff193f9752bcb70e6dcf53; record id: rna-fusion-leukaemia-20261011-result-etv6-ncoa2-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: dcecc337c03e9d19c65bbc0c1900cc36865c2c1cd9d6c6cc5b18d25ffd7fdc30; record id: rna-fusion-leukaemia-20261011-result-etv6-ncoa2-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: f53f010629918b3ba352704cce57bf1701cc75f1187d4ab8295f43c3ba97c296; record id: rna-fusion-leukaemia-20261011-result-etv6-runx1-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 396a21d0b06d10276fb9bf0b85f2cbd8bf8197087fa9813303f1917b3918da03; record id: rna-fusion-leukaemia-20261011-result-etv6-runx1-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 80fd0466324f015ac8e0f356ceb52c47a7bc7b5d4812d3cc2149fc47bf868205; record id: rna-fusion-leukaemia-20261011-result-etv6-runx1-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: df821084b00df10086612324748be82f9eb8d67b9136f8189b8254e5df6f0916; record id: rna-fusion-leukaemia-20261011-result-fus-znf362-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 34f1797cfea502f860817bd1be5015020e48fad44158d3be2a6d065081667008; record id: rna-fusion-leukaemia-20261011-result-fus-znf362-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 5ec837d1e63c5405b8d6d0b0ff25456cad2cd24321e567d78015ce92957b7c77; record id: rna-fusion-leukaemia-20261011-result-fus-znf362-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 3cc049edfc0d7b405409e2d16f93b1085a01057ddb9196018cc4921020eb55c9; record id: rna-fusion-leukaemia-20261011-result-hnrnph1-erg-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: c3b916c124c42603f99279ae166874615978d3210ad66239ca83f782d0c6da39; record id: rna-fusion-leukaemia-20261011-result-hnrnph1-erg-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 00e0c2b0001c4065b5de1700552a14dcf557b8db18197af370922de50f71885c; record id: rna-fusion-leukaemia-20261011-result-hnrnph1-erg-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 60fe8d5e8037c8f6715701fac1d5e9dba9d8b64f57792b311da55c1b9ac4544d; record id: rna-fusion-leukaemia-20261011-result-igh-cebpa-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 79e884618f5be5c1351245db20f8db8dc3e2cc75f387b03b0235672c4fe16104; record id: rna-fusion-leukaemia-20261011-result-igh-cebpa-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: e64f0ee7ab3a5f1063aac81740adfc3bf50bceb6c9e7f33cd866090b7c4cdd4c; record id: rna-fusion-leukaemia-20261011-result-igh-cebpa-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: b4f99c1fbad590cb29dd431325b4b0545a732406c4df39c8cdb3cfcae9e1c4b3; record id: rna-fusion-leukaemia-20261011-result-igh-crlf2-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 3ac52009ce4c5f68a41824886dc9732bcd101992fd533d951aaff83386a00c60; record id: rna-fusion-leukaemia-20261011-result-igh-crlf2-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: da65bd899e72651547f580245ef8a5de330ce7287e32c1d8efcd3c3cdaa1a954; record id: rna-fusion-leukaemia-20261011-result-igh-crlf2-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 028dc2f6d9bc571a9a47204bf4633f05336f90de3a1525d68bfab8dac7055733; record id: rna-fusion-leukaemia-20261011-result-kmt2a-ell-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: cad675649b8799247ba0331ddf461c4ec155be506c20d8207cc431b0c19576d0; record id: rna-fusion-leukaemia-20261011-result-kmt2a-ell-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: d18e2e9116c8841406c4b94f28843dacf223ec3fc93ded7b12bb29871ea9d721; record id: rna-fusion-leukaemia-20261011-result-kmt2a-ell-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: e6d79677d0b9741cd4d5cf463841ba3ad36a8e9b7dfc29641b246999cf7ce8cf; record id: rna-fusion-leukaemia-20261011-result-kmt2a-mllt10-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: e01f739114441e6bb48e929bdc68b89712b4c72af2f40866ad3a512d6c5f6327; record id: rna-fusion-leukaemia-20261011-result-kmt2a-mllt10-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: a07b6abdda4f757df4d4472f8e1dc04066f3dc3da007d2f73c31bfacbe54746c; record id: rna-fusion-leukaemia-20261011-result-kmt2a-mllt10-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: dc65d5d8a49b027c248442d590169c97bf220f2bcffb24cda47a0007b43c6863; record id: rna-fusion-leukaemia-20261011-result-kmt2a-mllt3-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 58aad0641e21512a8b17cf9160fa623d5181a5c6cf3df755aea4698bc99492c4; record id: rna-fusion-leukaemia-20261011-result-kmt2a-mllt3-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: dd97c73475a252df372bb66e9c12471e9775c69a9373eccd5d0f4de10a16fc4a; record id: rna-fusion-leukaemia-20261011-result-kmt2a-mllt3-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 638d96109417861edd70a9974abd36cd5d8ca873837914ef47b2428e0d94dcd2; record id: rna-fusion-leukaemia-20261011-result-kmt2a-unspecified-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: a247bb69007271277a19b1495a2a93ecb1975a4c568449de49be78128d79e96b; record id: rna-fusion-leukaemia-20261011-result-kmt2a-unspecified-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 5e26a4a4c50853aafde1ba31dde5805094c3d31beec5051aa247ed67a97e7b78; record id: rna-fusion-leukaemia-20261011-result-kmt2a-unspecified-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 57a95ecffd9b016d750c6ae3b9009ad7e7e75c5fbf86c072d92ee0fcb3c889da; record id: rna-fusion-leukaemia-20261011-result-mecom-unspecified-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 75b86e3f951c0e577df81a84289b90798de9362881d983f908802406de6d7883; record id: rna-fusion-leukaemia-20261011-result-mecom-unspecified-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 30aea258d6ca8901288844d8ce7026a8187f6dc318635073f6625ddb587877dc; record id: rna-fusion-leukaemia-20261011-result-mecom-unspecified-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 6d478d919d6101c0fb73b11897bd378d056542555117449df5869b0d80ec56f4; record id: rna-fusion-leukaemia-20261011-result-mllt10-ube2l6-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: b6cb809051bb8430faf5a17a7fb2f31fdbb4933ce48576c3e94c86db530b9b5e; record id: rna-fusion-leukaemia-20261011-result-mllt10-ube2l6-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 0796d117ee9252c1465739151f3594c207312fd0455fc3ac1c0b7a8546c85da6; record id: rna-fusion-leukaemia-20261011-result-mllt10-ube2l6-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 8c60f009b7640641948fd465edd99be5b5af9277501eea90b4d76907e7a31238; record id: rna-fusion-leukaemia-20261011-result-p2ry8-crlf2-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: b5b7ac017dab57a6804d31b25a6ddb56ec67812cb3eabda53d6ac3fc559c813a; record id: rna-fusion-leukaemia-20261011-result-p2ry8-crlf2-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 67e8a934ef65455fce9f1593e642babad7d901dfad984f2b96486ea8728f94b1; record id: rna-fusion-leukaemia-20261011-result-p2ry8-crlf2-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 4d4038525c63c312021dfbedb190d7002dc1e6a22fd9dce45e7f16d86b0468ff; record id: rna-fusion-leukaemia-20261011-result-pax5-jak2-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 48893c0bd87c3dd568281cbfae16c6abe1df780eca679da0e79fc27fa3a457d4; record id: rna-fusion-leukaemia-20261011-result-pax5-jak2-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: b395efd73adae4d9ea02ca25d23bdf2d15362186c974491a94f69303a16e391c; record id: rna-fusion-leukaemia-20261011-result-pax5-jak2-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 59079578713256e2ebdc993141d79dd77336699b047a3e534df624287538ffb2; record id: rna-fusion-leukaemia-20261011-result-pax5-nol4l-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 9f10dbebe24ef854f95ecd07c8229e462b5bc6b47626ddee0dd2208c7d47d7ca; record id: rna-fusion-leukaemia-20261011-result-pax5-nol4l-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 2fbbe8023b7aad4c668657c3c930cd7357bd3cce3675d65b9fbdc352072bea72; record id: rna-fusion-leukaemia-20261011-result-pax5-nol4l-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: bd964818278a02f1fa46f251c52a81b5a74df1d91aafbcf98d43b1d055a82d12; record id: rna-fusion-leukaemia-20261011-result-picalm-mllt10-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 14913c5e738d2017112a81ea56ae4f67c6858e5e981bfe10691e6cfe858030cd; record id: rna-fusion-leukaemia-20261011-result-picalm-mllt10-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 1b28dd60a4c8ae4174fbb76ae3ac288b45c3ceeb4b59ba2443917f925c165d18; record id: rna-fusion-leukaemia-20261011-result-picalm-mllt10-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: b1213bfd4dd00f4dc6b1e0a26c3f84cd6a322ee6f098bba82ec3d08bacef7ba3; record id: rna-fusion-leukaemia-20261011-result-pml-rara-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 3d3bcb85c93f51d029612a32003f1c499b28857e4cc4a7f85b369c0fcb84fb73; record id: rna-fusion-leukaemia-20261011-result-pml-rara-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 6f1617150330e59b9cde29c28ebabfb88aebe409fd31a2f0d3a1badf267b6af5; record id: rna-fusion-leukaemia-20261011-result-pml-rara-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: adff097f51f01ff37506ea6f18337594d7f0cebef390821bda6c605d47b38c49; record id: rna-fusion-leukaemia-20261011-result-runx1-runx1t1-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: cff3f7e5bd7fe63760975bf478991905684d0867459d3e51ffcc74a578809f62; record id: rna-fusion-leukaemia-20261011-result-runx1-runx1t1-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 7b24aff3b0d8bee5c51f3e02b331fe0a0b29b9af37f9dd1cbc3b925243ae08ee; record id: rna-fusion-leukaemia-20261011-result-runx1-runx1t1-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: c848c2ebbd482f675200499cfb5c3a2ecb5446219bf01f3bc2e2e7177c5454f1; record id: rna-fusion-leukaemia-20261011-result-runx1-unspecified-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: f7cb101a9b27cd53273fc412f3552b3d2407d431569bdab1f0906ad304200306; record id: rna-fusion-leukaemia-20261011-result-runx1-unspecified-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: ec9da5f2111f190980520c86645bed1cb7cdcca9f45cf6dd1005954add08e46c; record id: rna-fusion-leukaemia-20261011-result-runx1-unspecified-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 79030520e66b420ac327bb8150fa43a370314de3a34d8a5791eb0a6de5296433; record id: rna-fusion-leukaemia-20261011-result-runx1-usp42-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 6d9e887a0b3dc7de97ef2c21946151175110aa07a79323edc47b5dea5d418ab6; record id: rna-fusion-leukaemia-20261011-result-runx1-usp42-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: efc804ed0de5bed351f9a01dbca5bd914f8d9e4a74a4ba59cc59378a82a23b35; record id: rna-fusion-leukaemia-20261011-result-runx1-usp42-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: ee0a9a0548ce4b0b3dd6e42e7bfa1b80165eafa59d021d1eac2262925e1a5b79; record id: rna-fusion-leukaemia-20261011-result-stil-tal1-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: b1e9512f006665e12611f31599166903d7d64214093eb52578c1efba3b82b0c2; record id: rna-fusion-leukaemia-20261011-result-stil-tal1-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 57ff359197866e49d439f6c956dea59ae4af560c298d126604cf0dee9fe322dd; record id: rna-fusion-leukaemia-20261011-result-stil-tal1-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: ed858a1b77848e97621fb041768a216fa8f5079b524ad54375fa61df6bafbe27; record id: rna-fusion-leukaemia-20261011-result-tcf3-hlf-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 4c9e0d9cc3ae38e84a113647565bb38ecaf54543ac8e8ff8740623d292433239; record id: rna-fusion-leukaemia-20261011-result-tcf3-hlf-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 16c9b92cad55c558d41b95cbecf4843eec72bc9866fc672a8a83e5bb9e63d794; record id: rna-fusion-leukaemia-20261011-result-tcf3-hlf-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 9dd7d226bc707a74cbcab6ccc655b9ff434f07438069ce698f1804480bebdaf0; record id: rna-fusion-leukaemia-20261011-result-tra-d-unspecified-concordance; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: e06ad950197ebd8adefb859296643572694c898dbfda0841540c7c4cd01e0f49; record id: rna-fusion-leukaemia-20261011-result-tra-d-unspecified-conv; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: 239b3f43900ceda9f1facf5aa1e9d0298a0730f6efe086c71a0f85530cf626ef; record id: rna-fusion-leukaemia-20261011-result-tra-d-unspecified-rnaseq; fields: status; attributes.metric; attributes.metric_qualifier; attributes.printed_value; attributes.numeric_value; sha256: e7dd0be825cfd8e703c11ccb85878e06afe7c2bb5fccdd5257aea93f8ec9dff5; record id: rna-fusion-leukaemia-20261011-source-kim2025; fields: status; attributes.artifact_sha256; sha256: 660a9e63a81ee2560f3f48fa4e091bd1a305f681d835f212b52b41f599ad7fb6; record id: use-case-tumour-rna-fusion-detection; fields: status; name; description; facets; attributes.question; attributes.decision; attributes.inputs; attributes.output; attributes.exclusions; attributes.setting; attributes.clinical_scope; attributes.intended_users; sha256: 813ef5e1275c5b78b486810d5445b67c9069bf366d78399aa2098727d56b2d15

Related records

Suggest a correction