Evidence claim

Relevance of GenomeOcean-4B generation throughput, power and energy efficiency, BF16 versus FP8 (Yu et al. 2026) to "Select an execution workflow for large-scale diagnostic genomics"

Use case: Select an execution workflow for large-scale diagnostic genomics
Assessed by: GenomeOcean-4B autoregressive generation throughput, power, energy efficiency and perplexity, BF16 versus FP8 (Yu et al. 2026 Table 4)
Relevance: Proxy evidence
Endpoint: Generation throughput, GPU power and tokens per watt (mean and SD over five trials) and perplexity for GenomeOcean-4B with BF16, FP8 KV cache and W8A8 plus FP8 KV cache in vLLM on one H100

Measures generation throughput, power draw and energy efficiency of a genomic foundation model under three precision settings on stated hardware. Proxy: sequence generation is not a diagnostic workflow step, the sequences are microbial, and the study is author-reported.

3 reviewed evaluations

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

20 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Citation locations 1 values source id model-execution-20261011-source-yu2026-fp8-genomeocean locator Sections 2.2-2.7; Tables 3 and 4; Funding Statement and Author Contributions Context-only references	FP8 Inference in Genomic Foundation Models: Theoretical vs. Realized Speedups on GenomeOcean Original source ↗ model-execution-20261011-source-yu2026-fp8-genomeocean: Sections 2.2-2.7; Tables 3 and 4; Funding Statement and Author Contributions Version: bioRxiv preprint version 1, posted 2026-08-14 (PDF footer); bioRxiv API date 2026-08-18 Retrieved: 2026-10-11T21:42:49Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.citation_locators` Source artifact SHA-256: `ca54817d1f1a308f09bd3022e56cf6f8b86a875b110da0a38fe31236e39ca076` Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval (a second download differed in 40 bytes). The pdftotext -layout text layer (poppler) of both downloads has SHA-256 bec6e695ce46c4ebd6692e01a1a93167e212dffbb97b6558f1da88b1eb453501. Inspected artifact
Comparison group yu2026-genomeocean-fp8 Context-only references	FP8 Inference in Genomic Foundation Models: Theoretical vs. Realized Speedups on GenomeOcean Original source ↗ model-execution-20261011-source-yu2026-fp8-genomeocean: Sections 2.2-2.7; Tables 3 and 4; Funding Statement and Author Contributions Version: bioRxiv preprint version 1, posted 2026-08-14 (PDF footer); bioRxiv API date 2026-08-18 Retrieved: 2026-10-11T21:42:49Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.comparison_group` Source artifact SHA-256: `ca54817d1f1a308f09bd3022e56cf6f8b86a875b110da0a38fe31236e39ca076` Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval (a second download differed in 40 bytes). The pdftotext -layout text layer (poppler) of both downloads has SHA-256 bec6e695ce46c4ebd6692e01a1a93167e212dffbb97b6558f1da88b1eb453501. Inspected artifact
Comparison title GenomeOcean inference on one H100, BF16 versus FP8 (Yu et al. 2026) Context-only references	FP8 Inference in Genomic Foundation Models: Theoretical vs. Realized Speedups on GenomeOcean Original source ↗ model-execution-20261011-source-yu2026-fp8-genomeocean: Sections 2.2-2.7; Tables 3 and 4; Funding Statement and Author Contributions Version: bioRxiv preprint version 1, posted 2026-08-14 (PDF footer); bioRxiv API date 2026-08-18 Retrieved: 2026-10-11T21:42:49Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.comparison_title` Source artifact SHA-256: `ca54817d1f1a308f09bd3022e56cf6f8b86a875b110da0a38fe31236e39ca076` Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval (a second download differed in 40 bytes). The pdftotext -layout text layer (poppler) of both downloads has SHA-256 bec6e695ce46c4ebd6692e01a1a93167e212dffbb97b6558f1da88b1eb453501. Inspected artifact
Constraints 2 values Inspect every linked evaluation's source locator before citing a result. Do not combine this mapping's evaluations with any other protocol's results; hardware, inputs, software versions and timing boundaries differ between sources. Context-only references	FP8 Inference in Genomic Foundation Models: Theoretical vs. Realized Speedups on GenomeOcean Original source ↗ model-execution-20261011-source-yu2026-fp8-genomeocean: Sections 2.2-2.7; Tables 3 and 4; Funding Statement and Author Contributions Version: bioRxiv preprint version 1, posted 2026-08-14 (PDF footer); bioRxiv API date 2026-08-18 Retrieved: 2026-10-11T21:42:49Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.constraints` Source artifact SHA-256: `ca54817d1f1a308f09bd3022e56cf6f8b86a875b110da0a38fe31236e39ca076` Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval (a second download differed in 40 bytes). The pdftotext -layout text layer (poppler) of both downloads has SHA-256 bec6e695ce46c4ebd6692e01a1a93167e212dffbb97b6558f1da88b1eb453501. Inspected artifact
Endpoint Generation throughput, GPU power and tokens per watt (mean and SD over five trials) and perplexity for GenomeOcean-4B with BF16, FP8 KV cache and W8A8 plus FP8 KV cache in vLLM on one H100 Context-only references	FP8 Inference in Genomic Foundation Models: Theoretical vs. Realized Speedups on GenomeOcean Original source ↗ model-execution-20261011-source-yu2026-fp8-genomeocean: Sections 2.2-2.7; Tables 3 and 4; Funding Statement and Author Contributions Version: bioRxiv preprint version 1, posted 2026-08-14 (PDF footer); bioRxiv API date 2026-08-18 Retrieved: 2026-10-11T21:42:49Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.endpoint` Source artifact SHA-256: `ca54817d1f1a308f09bd3022e56cf6f8b86a875b110da0a38fe31236e39ca076` Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval (a second download differed in 40 bytes). The pdftotext -layout text layer (poppler) of both downloads has SHA-256 bec6e695ce46c4ebd6692e01a1a93167e212dffbb97b6558f1da88b1eb453501. Inspected artifact
Claimed field links:assessed_by:model-execution-20261011-protocol-yu2026-genomeocean-generation-fp8 Context-only references	FP8 Inference in Genomic Foundation Models: Theoretical vs. Realized Speedups on GenomeOcean Original source ↗ model-execution-20261011-source-yu2026-fp8-genomeocean: Sections 2.2-2.7; Tables 3 and 4; Funding Statement and Author Contributions Version: bioRxiv preprint version 1, posted 2026-08-14 (PDF footer); bioRxiv API date 2026-08-18 Retrieved: 2026-10-11T21:42:49Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.field` Source artifact SHA-256: `ca54817d1f1a308f09bd3022e56cf6f8b86a875b110da0a38fe31236e39ca076` Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval (a second download differed in 40 bytes). The pdftotext -layout text layer (poppler) of both downloads has SHA-256 bec6e695ce46c4ebd6692e01a1a93167e212dffbb97b6558f1da88b1eb453501. Inspected artifact
Headline metric inference-throughput Context-only references	FP8 Inference in Genomic Foundation Models: Theoretical vs. Realized Speedups on GenomeOcean Original source ↗ model-execution-20261011-source-yu2026-fp8-genomeocean: Sections 2.2-2.7; Tables 3 and 4; Funding Statement and Author Contributions Version: bioRxiv preprint version 1, posted 2026-08-14 (PDF footer); bioRxiv API date 2026-08-18 Retrieved: 2026-10-11T21:42:49Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.headline_metric` Source artifact SHA-256: `ca54817d1f1a308f09bd3022e56cf6f8b86a875b110da0a38fe31236e39ca076` Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval (a second download differed in 40 bytes). The pdftotext -layout text layer (poppler) of both downloads has SHA-256 bec6e695ce46c4ebd6692e01a1a93167e212dffbb97b6558f1da88b1eb453501. Inspected artifact
Limitations 6 values Author-reported: two authors are at the DOE Joint Genome Institute, which develops GenomeOcean; no competing-interest statement is printed. Microbial genomes (96 GTDB Bacteria sequences) and a perplexity check, not human diagnostic sequence; the paper says perplexity measures sequence-likelihood preservation, not the biological function of generated sequences (Section 4.4). Throughput, power and efficiency are mean and standard deviation over five trials; perplexity standard deviation reflects sequence-level heterogeneity across 96 fixed sequences, not trial-to-trial variation. Generation and embedding use different engines, so their absolute throughputs are not comparable (Section 2.4). Peak memory for generation is not printed in Table 4. One GPU type (H100 SXM5); the paper says results for other GPUs and engines need their own evaluation. Context-only references	FP8 Inference in Genomic Foundation Models: Theoretical vs. Realized Speedups on GenomeOcean Original source ↗ model-execution-20261011-source-yu2026-fp8-genomeocean: Sections 2.2-2.7; Tables 3 and 4; Funding Statement and Author Contributions Version: bioRxiv preprint version 1, posted 2026-08-14 (PDF footer); bioRxiv API date 2026-08-18 Retrieved: 2026-10-11T21:42:49Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.limitations` Source artifact SHA-256: `ca54817d1f1a308f09bd3022e56cf6f8b86a875b110da0a38fe31236e39ca076` Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval (a second download differed in 40 bytes). The pdftotext -layout text layer (poppler) of both downloads has SHA-256 bec6e695ce46c4ebd6692e01a1a93167e212dffbb97b6558f1da88b1eb453501. Inspected artifact
Pinned records 18 values record id model-execution-20261011-eval-yu2026-genomeocean-4b-bf16-vllm fields status links attributes.origin attributes.comparison sha256 030e815e0f085cc6688777b41f58c053c14d8d0f6bcb39facdb3011c32fed88b record id model-execution-20261011-eval-yu2026-genomeocean-4b-fp8-kv-vllm fields status links attributes.origin attributes.comparison sha256 3cdcc51d8362d44522a45a05ad5bbdb20a2929cba378bd828ce43b4f9d35afc8 record id model-execution-20261011-eval-yu2026-genomeocean-4b-w8a8-fp8-kv-vllm fields status links attributes.origin attributes.comparison sha256 67bee955aacbaebb0e00df242d39f6418281748488986b157d93fc8f08f34d29 record id model-execution-20261011-protocol-yu2026-genomeocean-generation-fp8 fields status name description facets source_ids links attributes sha256 0ef201207176e4af5bcc231ae01d5abc49a3b97f16b2780cac78f29f8dc56d5d record id model-execution-20261011-result-yu2026-genomeocean-4b-bf16-vllm-efficiency fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 24ec7fc6205ca4cb5c725ae7a4748351c684c7bedf6501585e298e2f8ee3cfe4 record id model-execution-20261011-result-yu2026-genomeocean-4b-bf16-vllm-perplexity fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 dbbd438d2e58bc948193b0fb21d423ff07ef46603f4ba83e21429dfcc30720c0 record id model-execution-20261011-result-yu2026-genomeocean-4b-bf16-vllm-power fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 2ee5f1798b23354250ba909e3eda47dde8b7748edeb606f2ef50d4babcb7d9f5 record id model-execution-20261011-result-yu2026-genomeocean-4b-bf16-vllm-throughput fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 086a37181126548c0d66d0996ace5b7c686931fa30834c5fe2bd59df11abfe83 record id model-execution-20261011-result-yu2026-genomeocean-4b-fp8-kv-vllm-efficiency fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 cd6202df388bb1e07e9fde5f1c14f044b03b0562b0a1a9298966a24d452f7bf7 record id model-execution-20261011-result-yu2026-genomeocean-4b-fp8-kv-vllm-perplexity fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 7f00ed9d6672ae2c12f99c01099ad2b7ea7b6e6114c40d0deb252ac34cb69e35 record id model-execution-20261011-result-yu2026-genomeocean-4b-fp8-kv-vllm-power fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 7abc0e84a05a42fe762db3fe64b1c84ae67730ae09bfb87b7b3b2838da414c0d record id model-execution-20261011-result-yu2026-genomeocean-4b-fp8-kv-vllm-throughput fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 0185aebf4fe19d617a94fc3fcfb20179ec47e4d5b91e1c9904ff43115c16ba08 record id model-execution-20261011-result-yu2026-genomeocean-4b-w8a8-fp8-kv-vllm-efficiency fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 f08db1a6dda332cbcac0fc740e21565240c82e661c8993f17f0366ca4f77a1a5 record id model-execution-20261011-result-yu2026-genomeocean-4b-w8a8-fp8-kv-vllm-perplexity fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 72e4c5752ccec73586c1c262c97de035262071804b7a2d8a1a1c278bc0877c4c record id model-execution-20261011-result-yu2026-genomeocean-4b-w8a8-fp8-kv-vllm-power fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 dc9794fc429418a6e8032d47675b3e58e0efbbdfaad972777850d4b187330fa6 record id model-execution-20261011-result-yu2026-genomeocean-4b-w8a8-fp8-kv-vllm-throughput fields status attributes.metric attributes.metric_qualifier attributes.printed_value attributes.numeric_value sha256 ba332834afd93ba0c5321fdd096490fc122153ac5b1d84fb0cb0439e46267ebd record id model-execution-20261011-source-yu2026-fp8-genomeocean fields status attributes.artifact_sha256 sha256 750269f81a30565ff23349ec4f0fc65f57272fc6df8a5520558273ad079d590b record id use-case-diagnostic-genomics-model-execution fields status name description facets attributes.question attributes.decision attributes.inputs attributes.output attributes.exclusions attributes.setting attributes.clinical_scope attributes.intended_users sha256 1c2a12431556cc6581f5aab019cf91576d2393387b88a8a2bea35ea2a3ee4a70 Context-only references	FP8 Inference in Genomic Foundation Models: Theoretical vs. Realized Speedups on GenomeOcean Original source ↗ model-execution-20261011-source-yu2026-fp8-genomeocean: Sections 2.2-2.7; Tables 3 and 4; Funding Statement and Author Contributions Version: bioRxiv preprint version 1, posted 2026-08-14 (PDF footer); bioRxiv API date 2026-08-18 Retrieved: 2026-10-11T21:42:49Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.pins` Source artifact SHA-256: `ca54817d1f1a308f09bd3022e56cf6f8b86a875b110da0a38fe31236e39ca076` Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval (a second download differed in 40 bytes). The pdftotext -layout text layer (poppler) of both downloads has SHA-256 bec6e695ce46c4ebd6692e01a1a93167e212dffbb97b6558f1da88b1eb453501. Inspected artifact
Rationale Measures generation throughput, power draw and energy efficiency of a genomic foundation model under three precision settings on stated hardware. Proxy: sequence generation is not a diagnostic workflow step, the sequences are microbial, and the study is author-reported. Context-only references	FP8 Inference in Genomic Foundation Models: Theoretical vs. Realized Speedups on GenomeOcean Original source ↗ model-execution-20261011-source-yu2026-fp8-genomeocean: Sections 2.2-2.7; Tables 3 and 4; Funding Statement and Author Contributions Version: bioRxiv preprint version 1, posted 2026-08-14 (PDF footer); bioRxiv API date 2026-08-18 Retrieved: 2026-10-11T21:42:49Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.rationale` Source artifact SHA-256: `ca54817d1f1a308f09bd3022e56cf6f8b86a875b110da0a38fe31236e39ca076` Hash scope: bioRxiv stamps each PDF download, so artifact_sha256 describes one retrieval (a second download differed in 40 bytes). The pdftotext -layout text layer (poppler) of both downloads has SHA-256 bec6e695ce46c4ebd6692e01a1a93167e212dffbb97b6558f1da88b1eb453501. Inspected artifact

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Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

FP8 Inference in Genomic Foundation Models: Theoretical vs. Realized Speedups on GenomeOcean · Original source · bioRxiv preprint version 1, posted 2026-08-14 (PDF footer); bioRxiv API date 2026-08-18

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Technical metadata and extraction receipts

Stable ID: use-case-mapping-model-execution-20261011-yu2026-genomeocean-generation-fp8

field: links:assessed_by:model-execution-20261011-protocol-yu2026-genomeocean-generation-fp8
value: model-execution-20261011-protocol-yu2026-genomeocean-generation-fp8
relevance: proxy
endpoint: Generation throughput, GPU power and tokens per watt (mean and SD over five trials) and perplexity for GenomeOcean-4B with BF16, FP8 KV cache and W8A8 plus FP8 KV cache in vLLM on one H100
rationale: Measures generation throughput, power draw and energy efficiency of a genomic foundation model under three precision settings on stated hardware. Proxy: sequence generation is not a diagnostic workflow step, the sequences are microbial, and the study is author-reported.
constraints: Inspect every linked evaluation's source locator before citing a result.; Do not combine this mapping's evaluations with any other protocol's results; hardware, inputs, software versions and timing boundaries differ between sources.
limitations: Author-reported: two authors are at the DOE Joint Genome Institute, which develops GenomeOcean; no competing-interest statement is printed.; Microbial genomes (96 GTDB Bacteria sequences) and a perplexity check, not human diagnostic sequence; the paper says perplexity measures sequence-likelihood preservation, not the biological function of generated sequences (Section 4.4).; Throughput, power and efficiency are mean and standard deviation over five trials; perplexity standard deviation reflects sequence-level heterogeneity across 96 fixed sequences, not trial-to-trial variation.; Generation and embedding use different engines, so their absolute throughputs are not comparable (Section 2.4).; Peak memory for generation is not printed in Table 4.; One GPU type (H100 SXM5); the paper says results for other GPUs and engines need their own evaluation.
revision: 1
reason: Add primary-source execution evidence from the diagnostic genomics execution literature pass (2026-10-11).
citation locators: source id: model-execution-20261011-source-yu2026-fp8-genomeocean; locator: Sections 2.2-2.7; Tables 3 and 4; Funding Statement and Author Contributions
source locator: model-execution-20261011-source-yu2026-fp8-genomeocean: Sections 2.2-2.7; Tables 3 and 4; Funding Statement and Author Contributions
comparison group: yu2026-genomeocean-fp8
comparison title: GenomeOcean inference on one H100, BF16 versus FP8 (Yu et al. 2026)
headline metric: inference-throughput
stratum label: Generation (4B)
stratum order: 2
review: method: source-hash-verification; independent-cell-check; scope-review; reviewer: claude; reviewer note: Claude (Opus 5.5) research agent uc-execution extracted and drafted; Claude (Opus 5.5) review agent reviewer-exec checked every value and this judgement against the pinned sources; reviewed at: 2026-10-12T07:50:32Z; note: Bounded primary-source transcription with independent cell check and relevance review. No execution, reproduction, qualified human scientific review or clinical validation.
reviewed evaluations: model-execution-20261011-eval-yu2026-genomeocean-4b-bf16-vllm; model-execution-20261011-eval-yu2026-genomeocean-4b-fp8-kv-vllm; model-execution-20261011-eval-yu2026-genomeocean-4b-w8a8-fp8-kv-vllm
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subject: Select an execution workflow for large-scale diagnostic genomics

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