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Evidence claim

Relevance of uc-binder-20261022-protocol-adaptyv-expression to "Which computational design workflow produces binders that work when they are made and tested?"

Use case
Design a new binder to a chosen target
Assessed by
Adaptyv EGFR competition cell-free expression rate
Relevance
Proxy evidence
Endpoint
Share of selected competition designs that expressed above 0.02 micrograms per millilitre in a third-party cell-free system

Proxy evidence. Expression is a precondition for a binding measurement, not the binding endpoint, but it is measured independently of the design methods and it is the stage where the competition improved most between rounds, from 73% to 94 or 95%.

5 reviewed evaluations

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

20 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statementOriginal source and locationReview and provenance
Citation locations
1 values
  • locator
    Sections 2.4 and 4.1; round 2 repository README, 'Protein Synthesis'
    source id
    uc-binder-20261022-source-adaptyv-preprint
Context-only references		Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition (Cotet et al., bioRxiv 2025)

Original source ↗

uc-binder-20261022-source-adaptyv-preprint: Sections 2.4 and 4.1; round 2 repository README, 'Protein Synthesis'

Version: bioRxiv preprint version 1
Retrieved: 2026-10-22T12:01:00Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.citation_locators

Source artifact SHA-256: 17039d69ecc37f45f6c402511b8f4497ce631003689fa95ad1ab221f8f787a4f

Hash scope: SHA-256 of one retrieval of a mutable web page. The hash describes that retrieval, not a stable artifact.

Inspected artifact

Comparison group
pipeline-attrition
Context-only references		Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition (Cotet et al., bioRxiv 2025)

Original source ↗

uc-binder-20261022-source-adaptyv-preprint: Sections 2.4 and 4.1; round 2 repository README, 'Protein Synthesis'

Version: bioRxiv preprint version 1
Retrieved: 2026-10-22T12:01:00Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.comparison_group

Source artifact SHA-256: 17039d69ecc37f45f6c402511b8f4497ce631003689fa95ad1ab221f8f787a4f

Hash scope: SHA-256 of one retrieval of a mutable web page. The hash describes that retrieval, not a stable artifact.

Inspected artifact

Comparison title
Attrition between a screen hit and a confirmed binder
Context-only references		Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition (Cotet et al., bioRxiv 2025)

Original source ↗

uc-binder-20261022-source-adaptyv-preprint: Sections 2.4 and 4.1; round 2 repository README, 'Protein Synthesis'

Version: bioRxiv preprint version 1
Retrieved: 2026-10-22T12:01:00Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.comparison_title

Source artifact SHA-256: 17039d69ecc37f45f6c402511b8f4497ce631003689fa95ad1ab221f8f787a4f

Hash scope: SHA-256 of one retrieval of a mutable web page. The hash describes that retrieval, not a stable artifact.

Inspected artifact

Constraints
2 values
  • Expression is not binding. Do not read an expression rate as evidence that a workflow produces working binders.
  • The round 2 rate is printed twice, as 95% (378 of 400) in Section 2.4 and as 94% in Section 4.1; both are recorded.
Context-only references		Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition (Cotet et al., bioRxiv 2025)

Original source ↗

uc-binder-20261022-source-adaptyv-preprint: Sections 2.4 and 4.1; round 2 repository README, 'Protein Synthesis'

Version: bioRxiv preprint version 1
Retrieved: 2026-10-22T12:01:00Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.constraints

Source artifact SHA-256: 17039d69ecc37f45f6c402511b8f4497ce631003689fa95ad1ab221f8f787a4f

Hash scope: SHA-256 of one retrieval of a mutable web page. The hash describes that retrieval, not a stable artifact.

Inspected artifact

Endpoint
Share of selected competition designs that expressed above 0.02 micrograms per millilitre in a third-party cell-free system
Context-only references		Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition (Cotet et al., bioRxiv 2025)

Original source ↗

uc-binder-20261022-source-adaptyv-preprint: Sections 2.4 and 4.1; round 2 repository README, 'Protein Synthesis'

Version: bioRxiv preprint version 1
Retrieved: 2026-10-22T12:01:00Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.endpoint

Source artifact SHA-256: 17039d69ecc37f45f6c402511b8f4497ce631003689fa95ad1ab221f8f787a4f

Hash scope: SHA-256 of one retrieval of a mutable web page. The hash describes that retrieval, not a stable artifact.

Inspected artifact

Claimed field
links:assessed_by:uc-binder-20261022-protocol-adaptyv-expression
Context-only references		Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition (Cotet et al., bioRxiv 2025)

Original source ↗

uc-binder-20261022-source-adaptyv-preprint: Sections 2.4 and 4.1; round 2 repository README, 'Protein Synthesis'

Version: bioRxiv preprint version 1
Retrieved: 2026-10-22T12:01:00Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.field

Source artifact SHA-256: 17039d69ecc37f45f6c402511b8f4497ce631003689fa95ad1ab221f8f787a4f

Hash scope: SHA-256 of one retrieval of a mutable web page. The hash describes that retrieval, not a stable artifact.

Inspected artifact

Headline metric
proportion
Context-only references		Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition (Cotet et al., bioRxiv 2025)

Original source ↗

uc-binder-20261022-source-adaptyv-preprint: Sections 2.4 and 4.1; round 2 repository README, 'Protein Synthesis'

Version: bioRxiv preprint version 1
Retrieved: 2026-10-22T12:01:00Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.headline_metric

Source artifact SHA-256: 17039d69ecc37f45f6c402511b8f4497ce631003689fa95ad1ab221f8f787a4f

Hash scope: SHA-256 of one retrieval of a mutable web page. The hash describes that retrieval, not a stable artifact.

Inspected artifact

Limitations
3 values
  • Preprint, not peer reviewed, written by the organisers.
  • The improvement is confounded with the change of ranking metric, the change of design population and the change of participants between rounds.
  • No uncertainty is printed.
Context-only references		Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition (Cotet et al., bioRxiv 2025)

Original source ↗

uc-binder-20261022-source-adaptyv-preprint: Sections 2.4 and 4.1; round 2 repository README, 'Protein Synthesis'

Version: bioRxiv preprint version 1
Retrieved: 2026-10-22T12:01:00Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.limitations

Source artifact SHA-256: 17039d69ecc37f45f6c402511b8f4497ce631003689fa95ad1ab221f8f787a4f

Hash scope: SHA-256 of one retrieval of a mutable web page. The hash describes that retrieval, not a stable artifact.

Inspected artifact

Pinned records
14 values
  • record id
    uc-binder-20261022-eval-adaptyv-bindcraft-gb1-expression
    fields
    • status
    • links
    • attributes.origin
    • attributes.comparison
    sha256
    005607a7e1682cf2d8d399346fda429e2a56718e397d3f889e43dc33191008ad
  • record id
    uc-binder-20261022-eval-adaptyv-bindcraft-r1-expression
    fields
    • status
    • links
    • attributes.origin
    • attributes.comparison
    sha256
    01beea9dd9617f50223d0cd3e666409a5c7795e1a76cfe4d026a3246146cccdf
  • record id
    uc-binder-20261022-eval-adaptyv-bindcraft-r2-expression
    fields
    • status
    • links
    • attributes.origin
    • attributes.comparison
    sha256
    18de04336663c0a2b15dbf661e7d7bc7b2b9449128c47587025198e04e796a74
  • record id
    uc-binder-20261022-eval-adaptyv-r1-expression
    fields
    • status
    • links
    • attributes.origin
    • attributes.comparison
    sha256
    0dd2daaaf59187e8fead3021c85572f8ba18f533eb282102e841c8179371432b
  • record id
    uc-binder-20261022-eval-adaptyv-r2-expression
    fields
    • status
    • links
    • attributes.origin
    • attributes.comparison
    sha256
    63d622d87fa7f73b97a5d6ac1a44a8629fde1fd6efd61cd30bfad481198423e5
  • record id
    uc-binder-20261022-protocol-adaptyv-expression
    fields
    • status
    • name
    • description
    • facets
    • source_ids
    • links
    • attributes
    sha256
    f60f277a41a4747c2aac3bdf1637339a2a8656d6d389ca18542c7e62de84655f
  • record id
    uc-binder-20261022-result-adaptyv-bindcraft-gb1-expressed
    fields
    • status
    • attributes.metric
    • attributes.metric_qualifier
    • attributes.printed_value
    • attributes.numeric_value
    sha256
    6888cb087970055701c84461736a3a1bb1769b75c2b2a2cd8db0d1d316b00695
  • record id
    uc-binder-20261022-result-adaptyv-bindcraft-r1-expressed
    fields
    • status
    • attributes.metric
    • attributes.metric_qualifier
    • attributes.printed_value
    • attributes.numeric_value
    sha256
    bfd8d377b7dd9b4ddef1818135357967a2ddc5c599121cea0ab286567667c09d
  • record id
    uc-binder-20261022-result-adaptyv-bindcraft-r2-expressed
    fields
    • status
    • attributes.metric
    • attributes.metric_qualifier
    • attributes.printed_value
    • attributes.numeric_value
    sha256
    b3002b00234d90d25a94aff5ea3aaa6ab6cba1afeac7f4e9f4b5d3ebccddc922
  • record id
    uc-binder-20261022-result-adaptyv-r1-expression-rate
    fields
    • status
    • attributes.metric
    • attributes.metric_qualifier
    • attributes.printed_value
    • attributes.numeric_value
    sha256
    6bff126ad149b85520d8f898d63280990873e986c817c0531bdb7071000e4756
  • record id
    uc-binder-20261022-result-adaptyv-r2-expression-rate-94
    fields
    • status
    • attributes.metric
    • attributes.metric_qualifier
    • attributes.printed_value
    • attributes.numeric_value
    sha256
    0086df00761e7ac9facd14e3ceeb365280d12beff91c54d167e5537d804a7c71
  • record id
    uc-binder-20261022-result-adaptyv-r2-expression-rate-95
    fields
    • status
    • attributes.metric
    • attributes.metric_qualifier
    • attributes.printed_value
    • attributes.numeric_value
    sha256
    56e0078ff429261ab16ad20eaeb4fc16766b9c00f51f59c09834e04452e15836
  • record id
    uc-binder-20261022-source-adaptyv-preprint
    fields
    • status
    • attributes.artifact_sha256
    sha256
    379c0dd17d6ebf91ee5b1d65f3247c89c6c16509fc4c6a764416712b02ec8f2d
  • record id
    use-case-de-novo-binder-design
    fields
    • status
    • name
    • description
    • facets
    • attributes.question
    • attributes.decision
    • attributes.inputs
    • attributes.output
    • attributes.exclusions
    • attributes.setting
    • attributes.clinical_scope
    • attributes.intended_users
    sha256
    b5a0012d1b0f02d6bd7466b7308123b26e676eda8ef54d706c865bb3f777e5b9
Context-only references		Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition (Cotet et al., bioRxiv 2025)

Original source ↗

uc-binder-20261022-source-adaptyv-preprint: Sections 2.4 and 4.1; round 2 repository README, 'Protein Synthesis'

Version: bioRxiv preprint version 1
Retrieved: 2026-10-22T12:01:00Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.pins

Source artifact SHA-256: 17039d69ecc37f45f6c402511b8f4497ce631003689fa95ad1ab221f8f787a4f

Hash scope: SHA-256 of one retrieval of a mutable web page. The hash describes that retrieval, not a stable artifact.

Inspected artifact

Rationale
Proxy evidence. Expression is a precondition for a binding measurement, not the binding endpoint, but it is measured independently of the design methods and it is the stage where the competition improved most between rounds, from 73% to 94 or 95%.
Context-only references		Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition (Cotet et al., bioRxiv 2025)

Original source ↗

uc-binder-20261022-source-adaptyv-preprint: Sections 2.4 and 4.1; round 2 repository README, 'Protein Synthesis'

Version: bioRxiv preprint version 1
Retrieved: 2026-10-22T12:01:00Z

not individually reviewed

No individual claim review recorded

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Field: attributes.rationale

Source artifact SHA-256: 17039d69ecc37f45f6c402511b8f4497ce631003689fa95ad1ab221f8f787a4f

Hash scope: SHA-256 of one retrieval of a mutable web page. The hash describes that retrieval, not a stable artifact.

Inspected artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: use-case-mapping-binder-20261022-adaptyv-expression

citation locators
locator: Sections 2.4 and 4.1; round 2 repository README, 'Protein Synthesis'; source id: uc-binder-20261022-source-adaptyv-preprint
comparison group
pipeline-attrition
comparison title
Attrition between a screen hit and a confirmed binder
constraints
Expression is not binding. Do not read an expression rate as evidence that a workflow produces working binders.; The round 2 rate is printed twice, as 95% (378 of 400) in Section 2.4 and as 94% in Section 4.1; both are recorded.
endpoint
Share of selected competition designs that expressed above 0.02 micrograms per millilitre in a third-party cell-free system
field
links:assessed_by:uc-binder-20261022-protocol-adaptyv-expression
headline metric
proportion
limitations
Preprint, not peer reviewed, written by the organisers.; The improvement is confounded with the change of ranking metric, the change of design population and the change of participants between rounds.; No uncertainty is printed.
rationale
Proxy evidence. Expression is a precondition for a binding measurement, not the binding endpoint, but it is measured independently of the design methods and it is the stage where the competition improved most between rounds, from 73% to 94 or 95%.
reason
Add measured de novo binder design outcomes from the 2026-10-22 use-case evidence pass (#176).
relevance
proxy
review
artifact sha256: 17039d69ecc37f45f6c402511b8f4497ce631003689fa95ad1ab221f8f787a4f; method: scope-review; independent-cell-check; ai-assisted-source-review; method note: Re-downloaded (HTTP 200, 493,217 bytes, the same byte count as the pinned retrieval) but the SHA-256 differs, as expected for a mutable bioRxiv page whose hash describes one retrieval. Every extracted value and every quoted sentence was then located verbatim in the new retrieval, so the difference is in page furniture and not in the evidence. One section attribution and one quotation were corrected.; note: Reviewed in docs/reviews/use-cases/binder-2026-10-22.md. Automated AI review of the source transcription only; it is not human scientific review and nothing here was reproduced experimentally.; retrieval url: https://www.biorxiv.org/content/10.1101/2025.04.17.648362v1.full; reviewed at: 2026-10-22T15:00:00Z; reviewer: claude; reviewer note: Claude review agent, independent of the extraction agent; no human review claimed; scope: Endpoint fit, relevance grade, constraints, limitations, comparison grouping and the evaluations listed in reviewed_evaluations.
reviewed evaluations
uc-binder-20261022-eval-adaptyv-bindcraft-gb1-expression; uc-binder-20261022-eval-adaptyv-bindcraft-r1-expression; uc-binder-20261022-eval-adaptyv-bindcraft-r2-expression; uc-binder-20261022-eval-adaptyv-r1-expression; uc-binder-20261022-eval-adaptyv-r2-expression
revision
1
source locator
uc-binder-20261022-source-adaptyv-preprint: Sections 2.4 and 4.1; round 2 repository README, 'Protein Synthesis'
stratum label
Adaptyv EGFR competition, third-party cell-free expression
stratum order
2
value
uc-binder-20261022-protocol-adaptyv-expression
pins
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