Evidence claim

Relevance of MFASS v2 to "Prioritise variants for splicing experiments"

Use case: Prioritise variants for splicing experiments
Assessed by: MFASS v2
Relevance: Proxy evidence
Endpoint: Historical corrected MFASS v2 ranking and top-100 follow-up precision for supervised feature and training-prior controls

Assay-matched measured comparison informs the research decision within its original population and protocol; prospective transfer is not established.

2 reviewed evaluations

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

32 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Citation locations 2 values source id rewire-mfass-v2-source locator results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json source id rewire-local-20260921-source-mfass-prior locator results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json Context-only references	Training class prior / majority: report Original source ↗ rewire-mfass-v2-source: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json; rewire-local-20260921-source-mfass-prior: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 1663d1f04b2bbd6dfcff77fea78129d30b0de191 Retrieved: 2026-09-22T21:18:22Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.citation_locators` Source artifact SHA-256: `89e06a2f7229f16b980254a6589eb808ec89137018388db98719beb72324f56a` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Citation locations 2 values source id rewire-mfass-v2-source locator results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json source id rewire-local-20260921-source-mfass-prior locator results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json Context-only references	MFASS v2 pinned rewire artifacts Original source ↗ rewire-mfass-v2-source: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json; rewire-local-20260921-source-mfass-prior: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bee9133b83f3aedaf2bbb9013f1875515845607e Retrieved: 2026-09-16T10:50:02Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.citation_locators` Source artifact SHA-256: `a3af693afc070b39b334e359beed7f9affd76f7456a4f9264e2d1e9dab26111d` Hash scope: Local imported data/benchmark-runs/mfass-v2.json; not the upstream repository or result-file hash
Constraints 3 values Inspect scored and eligible counts for every condition. Consult recorded paired comparisons before interpreting differences. This mapping contains only the two baseline configurations. Historical specialist and DNABERT2 evaluations remain outside this mapping. Context-only references	Training class prior / majority: report Original source ↗ rewire-mfass-v2-source: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json; rewire-local-20260921-source-mfass-prior: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 1663d1f04b2bbd6dfcff77fea78129d30b0de191 Retrieved: 2026-09-22T21:18:22Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.constraints` Source artifact SHA-256: `89e06a2f7229f16b980254a6589eb808ec89137018388db98719beb72324f56a` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Constraints 3 values Inspect scored and eligible counts for every condition. Consult recorded paired comparisons before interpreting differences. This mapping contains only the two baseline configurations. Historical specialist and DNABERT2 evaluations remain outside this mapping. Context-only references	MFASS v2 pinned rewire artifacts Original source ↗ rewire-mfass-v2-source: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json; rewire-local-20260921-source-mfass-prior: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bee9133b83f3aedaf2bbb9013f1875515845607e Retrieved: 2026-09-16T10:50:02Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.constraints` Source artifact SHA-256: `a3af693afc070b39b334e359beed7f9affd76f7456a4f9264e2d1e9dab26111d` Hash scope: Local imported data/benchmark-runs/mfass-v2.json; not the upstream repository or result-file hash
Endpoint Historical corrected MFASS v2 ranking and top-100 follow-up precision for supervised feature and training-prior controls Context-only references	Training class prior / majority: report Original source ↗ rewire-mfass-v2-source: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json; rewire-local-20260921-source-mfass-prior: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 1663d1f04b2bbd6dfcff77fea78129d30b0de191 Retrieved: 2026-09-22T21:18:22Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.endpoint` Source artifact SHA-256: `89e06a2f7229f16b980254a6589eb808ec89137018388db98719beb72324f56a` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Endpoint Historical corrected MFASS v2 ranking and top-100 follow-up precision for supervised feature and training-prior controls Context-only references	MFASS v2 pinned rewire artifacts Original source ↗ rewire-mfass-v2-source: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json; rewire-local-20260921-source-mfass-prior: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bee9133b83f3aedaf2bbb9013f1875515845607e Retrieved: 2026-09-16T10:50:02Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.endpoint` Source artifact SHA-256: `a3af693afc070b39b334e359beed7f9affd76f7456a4f9264e2d1e9dab26111d` Hash scope: Local imported data/benchmark-runs/mfass-v2.json; not the upstream repository or result-file hash
Excluded evaluations 3 values id rewire-evaluation-dnabert2-117m-frozen-pair-logreg reason Not in the reviewed mapping's evaluation list when use cases moved into the store (2026-10-09). id rewire-evaluation-pangolin-maskfalse reason Not in the reviewed mapping's evaluation list when use cases moved into the store (2026-10-09). id rewire-evaluation-spliceai-1-3-1 reason Not in the reviewed mapping's evaluation list when use cases moved into the store (2026-10-09). Context-only references	Training class prior / majority: report Original source ↗ rewire-mfass-v2-source: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json; rewire-local-20260921-source-mfass-prior: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 1663d1f04b2bbd6dfcff77fea78129d30b0de191 Retrieved: 2026-09-22T21:18:22Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.excluded_evaluations` Source artifact SHA-256: `89e06a2f7229f16b980254a6589eb808ec89137018388db98719beb72324f56a` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Excluded evaluations 3 values id rewire-evaluation-dnabert2-117m-frozen-pair-logreg reason Not in the reviewed mapping's evaluation list when use cases moved into the store (2026-10-09). id rewire-evaluation-pangolin-maskfalse reason Not in the reviewed mapping's evaluation list when use cases moved into the store (2026-10-09). id rewire-evaluation-spliceai-1-3-1 reason Not in the reviewed mapping's evaluation list when use cases moved into the store (2026-10-09). Context-only references	MFASS v2 pinned rewire artifacts Original source ↗ rewire-mfass-v2-source: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json; rewire-local-20260921-source-mfass-prior: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bee9133b83f3aedaf2bbb9013f1875515845607e Retrieved: 2026-09-16T10:50:02Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.excluded_evaluations` Source artifact SHA-256: `a3af693afc070b39b334e359beed7f9affd76f7456a4f9264e2d1e9dab26111d` Hash scope: Local imported data/benchmark-runs/mfass-v2.json; not the upstream repository or result-file hash
Claimed field links:assessed_by:rewire-mfass-v2 Context-only references	Training class prior / majority: report Original source ↗ rewire-mfass-v2-source: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json; rewire-local-20260921-source-mfass-prior: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: 1663d1f04b2bbd6dfcff77fea78129d30b0de191 Retrieved: 2026-09-22T21:18:22Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.field` Source artifact SHA-256: `89e06a2f7229f16b980254a6589eb808ec89137018388db98719beb72324f56a` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact
Claimed field links:assessed_by:rewire-mfass-v2 Context-only references	MFASS v2 pinned rewire artifacts Original source ↗ rewire-mfass-v2-source: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json; rewire-local-20260921-source-mfass-prior: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json Shared locator for this statement’s cited sources; not a separate locator for each citation. Version: bee9133b83f3aedaf2bbb9013f1875515845607e Retrieved: 2026-09-16T10:50:02Z	not individually reviewed No individual claim review recorded Audit details Field: `attributes.field` Source artifact SHA-256: `a3af693afc070b39b334e359beed7f9affd76f7456a4f9264e2d1e9dab26111d` Hash scope: Local imported data/benchmark-runs/mfass-v2.json; not the upstream repository or result-file hash

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

2 source records and release history

MFASS v2 pinned rewire artifacts · Original source · bee9133b83f3aedaf2bbb9013f1875515845607e
Training class prior / majority: report · Original source · 1663d1f04b2bbd6dfcff77fea78129d30b0de191

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: use-case-mapping-20260930-339-25925e279972

field: links:assessed_by:rewire-mfass-v2
value: rewire-mfass-v2
relevance: proxy
endpoint: Historical corrected MFASS v2 ranking and top-100 follow-up precision for supervised feature and training-prior controls
rationale: Assay-matched measured comparison informs the research decision within its original population and protocol; prospective transfer is not established.
constraints: Inspect scored and eligible counts for every condition.; Consult recorded paired comparisons before interpreting differences.; This mapping contains only the two baseline configurations. Historical specialist and DNABERT2 evaluations remain outside this mapping.
limitations: Historical v2 annotation/coverage differs from matched-annotation v1: do not combine measurements.; Each method uses its own scored subset; marginal point scores do not establish a matched winner.; The constant prior has tied predictions; top-100 positives depend on fixed label-independent tie order.; Assay labels are not patient RNA or clinical endpoints.; DNABERT2 is represented as a pipeline, which is ineligible for this exact-configuration use-case mapping. Its existing evaluation remains in the catalogue and coverage audit; no record was promoted or score duplicated.
revision: 1
reason: Add independently checked primary-source protocol evidence from the 17-use-case coverage audit; retain narrower endpoint and transfer limitations.
citation locators: source id: rewire-mfass-v2-source; locator: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json; source id: rewire-local-20260921-source-mfass-prior; locator: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json
source locator: rewire-mfass-v2-source: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json; rewire-local-20260921-source-mfass-prior: results/baseline-kmer-position-v2.json; matched specialist and DNABERT2 result files; training-prior.report.json
excluded evaluations: id: rewire-evaluation-dnabert2-117m-frozen-pair-logreg; reason: Not in the reviewed mapping's evaluation list when use cases moved into the store (2026-10-09).; id: rewire-evaluation-pangolin-maskfalse; reason: Not in the reviewed mapping's evaluation list when use cases moved into the store (2026-10-09).; id: rewire-evaluation-spliceai-1-3-1; reason: Not in the reviewed mapping's evaluation list when use cases moved into the store (2026-10-09).
review: method: automated-source-review; reviewer: codex; reviewer note: Codex source curation, independent worker cross-review and root integration review; reviewed at: 2026-09-30T21:54:30.217Z; note: Source-backed literature curation with independent automated transcription and scope checks. No new model execution, independent experimental replication, qualified human scientific review or clinical validation.
reviewed evaluations: rewire-evaluation-baseline-kmer-position-v2; rewire-local-20260921-evaluation-mfass-prior
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subject: Prioritise variants for splicing experiments

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