AlphaProteo Table 1 pools three different design systems
Aggregation scope of AlphaProteo, pooled over tested design systems
Section S2, verbatim: 'We experimentally tested a design system containing the v1 model against all 7 targets, a v1-based system with an improved filter against SC2RBD and PD-L1, and a v2-based system on PD-L1 and TrkA (Table S2). Both improving the filter and the model resulted in increased experimental success rates. For simplicity, the results in Table 1 are pooled over all tested designs for each target.' The Table S2 denominators sum to the Table 1 denominators: SC2RBD 94+47+31=172, PD-L1 94+31+34=159, TrkA 94+37=131, TNF-alpha 30+24=54. Changing the filter alone moved the PD-L1 rate from 9.6% over 94 designs to 16.1% over 31 designs.
Table 1's AlphaProteo column is not one design system. Section S2 states that the results are pooled over all tested designs per target, and Table S2 shows that for SC2RBD, PD-L1, TrkA and TNF-alpha the pooled set mixes the v1 model, v1 with improved filters, and v2.
Evidence
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6 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Claimed field aggregation_scope Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Section S2; Table 1; Table S2 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Source location Section S2; Table 1; Table S2 Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Section S2; Table 1; Table S2 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Claimed value Section S2, verbatim: 'We experimentally tested a design system containing the v1 model against all 7 targets, a v1-based system with an improved filter against SC2RBD and PD-L1, and a v2-based system on PD-L1 and TrkA (Table S2). Both improving the filter and the model resulted in increased experimental success rates. For simplicity, the results in Table 1 are pooled over all tested designs for each target.' The Table S2 denominators sum to the Table 1 denominators: SC2RBD 94+47+31=172, PD-L1 94+31+34=159, TrkA 94+37=131, TNF-alpha 30+24=54. Changing the filter alone moved the PD-L1 rate from 9.6% over 94 designs to 16.1% over 31 designs. Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Section S2; Table 1; Table S2 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Description Table 1's AlphaProteo column is not one design system. Section S2 states that the results are pooled over all tested designs per target, and Table S2 shows that for SC2RBD, PD-L1, TrkA and TNF-alpha the pooled set mixes the v1 model, v1 with improved filters, and v2. Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Section S2; Table 1; Table S2 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Relationship: subject uc-binder-20261022-config-alphaproteo-pooled Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Section S2; Table 1; Table S2 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
| Name AlphaProteo Table 1 pools three different design systems Context-only references | De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) Section S2; Table 1; Table S2 Version: arXiv version 1, posted 2024-09-12; full-text PDF (49 pages) | not individually reviewed No individual claim review recorded Source has a recorded evidence concern. Consult its source page before using the claim. Audit detailsField: Source artifact SHA-256: Hash scope: SHA-256 of one retrieval of the arXiv v1 PDF on 2026-10-22. |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- De novo design of high-affinity protein binders with AlphaProteo (Zambaldi et al., arXiv 2024) · Original source · arXiv version 1, posted 2024-09-12; full-text PDF (49 pages)
Technical metadata and extraction receipts
Stable ID: uc-binder-20261022-claim-alphaproteo-table1-pools-design-systems
- field
- aggregation_scope
- review
- artifact sha256: 953b35644c0fa06ff090d7614c2e19525831f8fde50242e176d54474133c5a42; method: source-hash-verification; independent-cell-check; ai-assisted-source-review; method note: Re-downloaded with curl (HTTP 200, 12,333,400 bytes) and the SHA-256 recomputed and matched. Own text layer made with pdftotext -layout (poppler 26.08.0), reproducing the extraction pass's 2,811 lines. Table 1, Table S2, Table S3 and Sections S1.2.1, S2, S4.1 and S4.2 read cell by cell and compared with every record. Column assignment re-derived arithmetically rather than trusted.; note: Reviewed in docs/reviews/use-cases/binder-2026-10-22.md. Automated AI review of the source transcription only; it is not human scientific review and nothing here was reproduced experimentally.; retrieval url: https://arxiv.org/pdf/2409.08022v1; reviewed at: 2026-10-22T15:00:00Z; reviewer: claude; reviewer note: Claude review agent, independent of the extraction agent; no human review claimed
- source locator
- Section S2; Table 1; Table S2
- value
- Section S2, verbatim: 'We experimentally tested a design system containing the v1 model against all 7 targets, a v1-based system with an improved filter against SC2RBD and PD-L1, and a v2-based system on PD-L1 and TrkA (Table S2). Both improving the filter and the model resulted in increased experimental success rates. For simplicity, the results in Table 1 are pooled over all tested designs for each target.' The Table S2 denominators sum to the Table 1 denominators: SC2RBD 94+47+31=172, PD-L1 94+31+34=159, TrkA 94+37=131, TNF-alpha 30+24=54. Changing the filter alone moved the PD-L1 rate from 9.6% over 94 designs to 16.1% over 31 designs.