reference_standard_definition: dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis
Reference standard definition of Patient-level detection of causative pathogens in blood against the final clinical diagnosis (Huang et al. 2026 Table 2)
The final clinical diagnosis integrated clinical symptoms, infection markers, pathology, imaging, standard-of-care tests (smear, culture, serology and PCR) and NGS results, and was adjudicated by ICU clinicians with multidisciplinary review.
Descriptive fact transcribed from the pinned source.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
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6 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Claimed field reference_standard_definition Context-only references | Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Methods 'Clinical diagnosis' paragraph 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Source location Methods 'Clinical diagnosis' paragraph 1 Context-only references | Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Methods 'Clinical diagnosis' paragraph 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Claimed value The final clinical diagnosis integrated clinical symptoms, infection markers, pathology, imaging, standard-of-care tests (smear, culture, serology and PCR) and NGS results, and was adjudicated by ICU clinicians with multidisciplinary review. Context-only references | Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Methods 'Clinical diagnosis' paragraph 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Description Descriptive fact transcribed from the pinned source. Context-only references | Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Methods 'Clinical diagnosis' paragraph 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Relationship: subject dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Context-only references | Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Methods 'Clinical diagnosis' paragraph 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
| Name reference_standard_definition: dna-pathogen-20261011-huang2026-protocol-clinical-diagnosis Context-only references | Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis Methods 'Clinical diagnosis' paragraph 1 Version: Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML | not individually reviewed No individual claim review recorded Audit detailsField: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Blood-based targeted sequencing of microbial cell-free DNA in severe pneumonia-associated sepsis · Original source · Respiratory Research 27:357, published 2026-06-24; PMC13584460 full-text XML
Technical metadata and extraction receipts
Stable ID: dna-pathogen-20261011-huang2026-claim-reference-incorporates-ngs
- field
- reference_standard_definition
- value
- The final clinical diagnosis integrated clinical symptoms, infection markers, pathology, imaging, standard-of-care tests (smear, culture, serology and PCR) and NGS results, and was adjudicated by ICU clinicians with multidisciplinary review.
- source locator
- Methods 'Clinical diagnosis' paragraph 1
- review
- method: source-hash-verification; independent-cell-check; scope-review; reviewer: claude; reviewer note: Separate Claude review agent (reviewer-path), independent of the extractor; no human review claimed; date: 2026-10-11; artifact sha256: 79b237d733d9ad3af33722c30013afb0539adf03098ca1e1c2f18344bcc4a67d; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13584460/fullTextXML; method note: Transcribed from the pinned article XML text.; note: Re-downloaded the pinned artifact and matched its SHA-256; compared every value with a separate stdlib parser written for this review (the extractor's script was not run) and checked a stratified sample by hand against the rendered table.