Hu 2026 BRCA2 integrated functional-data classification study
Published-study grouping of the catalogued evaluation protocol. This grouping does not claim an executable suite, full-paper extraction or independent clinical validation.
Overview
Published-study grouping of the catalogued evaluation protocol. This grouping does not claim an executable suite, full-paper extraction or independent clinical validation.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
1 recorded evaluation, 1 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.
Results
Results are available, but no reviewed comparison panel is linked in this release.
All evaluations
1 evaluation · 1 result. Different protocols are not a single leaderboard.
Filter evaluations
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Integrated VarCall model (combined SGE functional data) | Protocol: Hu 2026 BRCA2 functional-integration classification yield Dataset: Hu 2026 BRCA2 integrated SGE functional-assay cohort | 92.8% (5926/6383) classified_as_p_lp_or_b_lb_fraction percent · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Author-reported evaluation · Source checkedMethods, coverage and sourceHu 2026 integrated functional-data classification evaluation Not reported Aggregation: Not reported Combining multiplexed assays of variant effect for enhanced BRCA2 variant classification · Results, "Incorporation of the 'Integrated VarCall model' functional data into the BRCA1/2 ClinGen variant classification specifications": "Thus, 92.8% (5926 of 6383) overall... were classified as P/LP or B/LB." |
Source checking is not independent reproduction. Release 2026-10-06-fea06f63ac0e.
Methods and evaluation design
Procedure, tasks and evaluated configurations
Evaluation design
Benchmarks bring together tasks and protocols. A task describes the biological question; a protocol defines a particular test.
These source-backed links do not make different protocols or scores interchangeable.
Baseline coverage
Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.
0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.
Baseline status by linked protocol
- Hu 2026 BRCA2 functional-integration classification yield · 0/2 roles measured
Protocol coverage CSV · Model evaluation matrix · Source table · Release and checksums
Coverage is derived from release 2026-10-06-fea06f63ac0e. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.
Run this benchmark
Choose a concrete protocol before running an evaluation. Its inputs, split and scoring rules determine which results can be compared.
Run instructions
No runnable recipe has been reviewed for this benchmark. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.
Strengths, limitations and unresolved questions
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
0 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|
No evidence rows match these filters. Choose another scope or clear the search.
Sources and history
View linked audit checks and correction history
Release 2026-10-06-fea06f63ac0e · Record review: source checked
1 source records and release history
- Combining multiplexed assays of variant effect for enhanced BRCA2 variant classification · Original source · 2026 published article (Nature Communications), published 2026-04-09; ENIGMA BRCA1/BRCA2 VCEP specification v1.2.0 applied
Technical metadata and extraction receipts
Stable ID: uc-clinical-20261005-hu-2026-benchmark
- areas
- dna-genomes
- contexts
- clinical_research
- entity level
- suite
- grouping type
- published_study_evaluations
- executable suite
- false
- source locator
- Results, "Incorporation of the 'Integrated VarCall model' functional data into the BRCA1/2 ClinGen variant classification specifications"
- review
- method: automated_source_review; reviewer: Claude Sonnet clinical coverage worker (research-evidence intake); date: 2026-10-05; note: Transcription from inspected primary source. No execution, independent replication or human scientific review.; source id: uc-clinical-20261005-source-hu-2026