92.8% (5926/6383) classified_as_p_lp_or_b_lb_fraction
Hu 2026 integrated functional data: classified_as_p_lp_or_b_lb_fraction
- Tested configuration
- Integrated VarCall model (combined SGE functional data)
- Protocol
- Hu 2026 BRCA2 functional-integration classification yield
- Dataset
- Hu 2026 BRCA2 integrated SGE functional-assay cohort
- Procedure
- Not reported
- Evaluation
- Hu 2026 integrated functional-data classification evaluation
- Coverage
- scored: unreported; eligible: unreported
- Uncertainty
- Not reported
- Evidence
- Author-reported evaluation · source checkedCombining multiplexed assays of variant effect for enhanced BRCA2 variant classification · Results, "Incorporation of the 'Integrated VarCall model' functional data into the BRCA1/2 ClinGen variant classification specifications": "Thus, 92.8% (5926 of 6383) overall... were classified as P/LP or B/LB."
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- Not reported
- Adaptation
- Not reported
- Scoring implementation
- Source-defined endpoint; see result source_locator
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 92.8% (5926/6383) Individual claims | Combining multiplexed assays of variant effect for enhanced BRCA2 variant classification Results, "Incorporation of the 'Integrated VarCall model' functional data into the BRCA1/2 ClinGen variant classification specifications": "Thus, 92.8% (5926 of 6383) overall... were classified as P/LP or B/LB." Version: 2026 published article (Nature Communications), published 2026-04-09; ENIGMA BRCA1/BRCA2 VCEP specification v1.2.0 applied | source checked automated source review · 2026-10-05 author reported Audit detailsTranscription from inspected primary source. No execution, independent replication or human scientific review. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record |
Sources and history
View linked audit checks and correction history
Release 2026-10-06-fea06f63ac0e · Record review: source checked
1 source records and release history
- Combining multiplexed assays of variant effect for enhanced BRCA2 variant classification · Original source · 2026 published article (Nature Communications), published 2026-04-09; ENIGMA BRCA1/BRCA2 VCEP specification v1.2.0 applied
Technical metadata and extraction receipts
Stable ID: uc-clinical-20261005-hu-2026-classified-yield
- areas
- dna-genomes
- contexts
- clinical_research
- metric
- classified_as_p_lp_or_b_lb_fraction
- unit
- percent
- printed value
- 92.8% (5926/6383)
- numeric value
- 92.8
- metric direction
- higher
- uncertainty
- Not reported
- numerator
- 5926
- denominator
- 6383
- source locator
- Results, "Incorporation of the 'Integrated VarCall model' functional data into the BRCA1/2 ClinGen variant classification specifications": "Thus, 92.8% (5926 of 6383) overall... were classified as P/LP or B/LB."
- review
- method: automated_source_review; reviewer: Claude Sonnet clinical coverage worker (research-evidence intake); date: 2026-10-05; note: Transcription from inspected primary source. No execution, independent replication or human scientific review.; source id: uc-clinical-20261005-source-hu-2026
- missing metadata
- uncertainty: not reported for this endpoint