Universal antibody-antigen affinity evaluation on AlphaBind (MochiBind study)
Evaluation framework for antibody-antigen binding affinity on four AlphaBind antigen systems with each antigen held out in turn; pairwise accuracy and retrieval metrics.
Results are recorded on the linked protocols, tasks or configurations listed below. Their settings and evaluations are kept separate.
Overview
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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Results on linked records
This benchmark has no results of its own in this release. 4 linked records have results. They are not assigned to the underlying benchmark: each record keeps its own settings and evaluations, and its scores are on its own page.
- AlphaBind PEM held-out antigen, pairwise accuracy Protocol · part of this benchmark · 4 evaluations · 4 results
- AlphaBind PP489 held-out antigen, pairwise accuracy Protocol · part of this benchmark · 4 evaluations · 4 results
- AlphaBind TRA held-out antigen, pairwise accuracy Protocol · part of this benchmark · 4 evaluations · 4 results
- AlphaBind VHH72 held-out antigen, pairwise accuracy Protocol · part of this benchmark · 4 evaluations · 4 results
Methods and evaluation design
Procedure, tasks and evaluated configurations
Baseline coverage
Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.
0 of 8 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.
Baseline status by linked protocol
- AlphaBind PEM held-out antigen, pairwise accuracy · 0/2 roles measured
- AlphaBind PP489 held-out antigen, pairwise accuracy · 0/2 roles measured
- AlphaBind TRA held-out antigen, pairwise accuracy · 0/2 roles measured
- AlphaBind VHH72 held-out antigen, pairwise accuracy · 0/2 roles measured
Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)
Coverage is derived from release 2026-10-22-1b7cf027e4f6. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.
Run instructions
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Strengths, limitations and unresolved questions
Evidence
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Evidence table
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- A systematic evaluation framework for universal antibody-antigen binding affinity prediction and candidate recommendation · Original source · iScience 2026, 116522; PMC13444443 full-text XML
Technical metadata and extraction receipts
Stable ID: lit-interactions-20261011-mochibind-benchmark-alphabind-universal-affinity
- areas
- molecular-interactions; proteins-complexes
- contexts
- research
- entity level
- suite
- version
- iScience 2026, 116522
- task
- Antibody-antigen relative binding affinity prediction
- scope note
- Pairwise accuracy (Table 2) only; retrieval metrics are in figures.
- source locator
- Introduction; Figure 1; STAR Methods; Table 2