rewirebio.iobenchmarks
Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

  • 121open
  • 5settled
  • 7resolved
  • 1medium severity
  • 132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

Showing findings that compare ESM3. All models

1 finding matches, most severe first.

ESM3 and ProteinMPNN: ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design and proteinbench primary benchmark evidence disagree

  • Low severity
  • Explained
  • two-study-conflict
  • different-task

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design ranks ESM3 above ProteinMPNN in 18 of 19 comparisons; proteinbench primary benchmark evidence ranks ProteinMPNN above ESM3 in 10 of 10 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank ESM3 above ProteinMPNN in 18 of their 29 comparisons and ProteinMPNN higher in 11. Of those papers, proteinbench primary benchmark evidence ranks ProteinMPNN higher on its own (10 of 10).

Comparisons in which each paper scores ESM3 or ProteinMPNN higher2 other papers: ESM3 higher in 18, ProteinMPNN higher in 11, 0 ties.2 other papers18 ESM3 higher1811 ProteinMPNN higher11
ESM3 higherTieProteinMPNN higher
Compared
ESM3, ProteinMPNN

2 follow-up actions, latest 24 October 2026

Resolved

Findings the check no longer makes, kept with their follow-up history: usually because a confirmed error led us to withdraw the results involved.