rewirebio.iobenchmarks
Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

  • 121open
  • 5settled
  • 7resolved
  • 1medium severity
  • 132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

2 findings match, most severe first.

ESM-2 and ESM3: ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design and pfmbench primary benchmark evidence disagree

  • Medium severity
  • Under investigation
  • two-study-conflict
  • Same task, different protocols

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design ranks ESM3 above ESM-2 in 18 of 18 comparisons; pfmbench primary benchmark evidence ranks ESM-2 above ESM3 in 9 of 12 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank ESM-2 above ESM3 in 9 of their 31 comparisons and ESM3 higher in 21; 1 is a tie. Of those papers, ProteinGym ranks ESM3 higher on its own (18 of 19).

Comparisons in which each paper scores ESM-2 or ESM3 higher2 other papers: ESM-2 higher in 9, ESM3 higher in 21, 1 tie.2 other papers9 ESM-2 higher91 tie21 ESM3 higher21
ESM-2 higherTieESM3 higher
Compared
ESM-2, ESM3

2 follow-up actions, latest 24 October 2026. Next check 6 November 2026

ESM-1b and EVE: Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods reverses the order

  • Low severity
  • Under investigation
  • Ordering reversal
  • Same task, different protocols

Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods ranks ESM-1b above EVE in 6 of 6 comparisons; 2 of 2 other studies rank EVE above ESM-1b.

2 papers rank EVE above ESM-1b in 22 of their 26 comparisons and ESM-1b higher in 1; 3 are ties. Brandes et al. 2023 ranks ESM-1b above EVE in all 6 comparisons that are not ties (2 are ties).

Comparisons in which each paper scores EVE or ESM-1b higher2 other papers: EVE higher in 22, ESM-1b higher in 1, 3 ties. Brandes et al. 2023 (disagrees): EVE higher in 0, ESM-1b higher in 6, 2 ties.2 other papers22 EVE higher223 tie31 ESM-1b higherDisagrees: Brandes et al. 2023Brandes et al. 2023 Supplementary Table 2: full benchmark evaluations of ESM1b and all other methods2 tie26 ESM-1b higher6
EVE higherTieESM-1b higher
Compared
ESM-1b, EVE

1 follow-up action, latest 23 October 2026. Next check 6 November 2026