rewirebio.iobenchmarks
Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

  • 121open
  • 5settled
  • 7resolved
  • 1medium severity
  • 132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

Showing findings that compare EVmutation. All models

2 findings match, most severe first.

EVmutation and Tranception: ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design and Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) disagree

  • Low severity
  • Not yet reviewed
  • two-study-conflict
  • different-task

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design ranks Tranception above EVmutation in 15 of 18 comparisons; Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks EVmutation above Tranception in 7 of 7 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank EVmutation above Tranception in 10 of their 26 comparisons and Tranception higher in 15; 1 is a tie. Of those papers, ProteinGym ranks Tranception higher on its own (15 of 19).

Comparisons in which each paper scores EVmutation or Tranception higher2 other papers: EVmutation higher in 10, Tranception higher in 15, 1 tie.2 other papers10 EVmutation higher101 tie15 Tranception higher15
EVmutation higherTieTranception higher
Compared
EVmutation, Tranception

Not reviewed yet.

EVmutation and CARP: ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design and Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) disagree

  • Low severity
  • Not yet reviewed
  • two-study-conflict
  • different-task

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design ranks EVmutation above CARP in 15 of 19 comparisons; Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks CARP above EVmutation in 5 of 6 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank EVmutation above CARP in 16 of their 25 comparisons and CARP higher in 9. Of those papers, Livesey and Marsh 2025 ranks CARP higher on its own (5 of 6).

Comparisons in which each paper scores EVmutation or CARP higher2 other papers: EVmutation higher in 16, CARP higher in 9, 0 ties.2 other papers16 EVmutation higher169 CARP higher9
EVmutation higherTieCARP higher
Compared
EVmutation, CARP

Not reviewed yet.