rewirebio.iobenchmarks
Evidence and investigation

Contested results

Where one study disagrees with what other studies report for the same models, and what we are doing to resolve each case.

These are automatic leads, not findings of error. Each release, a check compares how every study ranks the models it shares with other studies. It flags a study that reverses the order the others agree on, or whose gap to a shared reference model lies well outside theirs. Different tasks, populations or metrics often explain a flag.

A flag never hides a result. Flagged results stay in every table, page and download, marked Contested. A result is withheld only when a reviewer marks it disputed.

How the check works, and how each follow-up is recorded: discrepancies between studies.

In this release

  • 121open
  • 5settled
  • 7resolved
  • 1medium severity
  • 132low severity

Release 2026-11-02-a7f03c9e55a5 · 133 findings in all · rules version 4

Findings

Status: All · Open · Settled · Resolved

Severity: All · Medium · Low

State: All · Not yet reviewed · Under investigation · Explained · Confirmed error · Not a real disagreement

5 findings match, most severe first.

DNABERT-2 and RNA-FM: mRNABench: A curated benchmark for mature mRNA property and function prediction reverses the order

  • Low severity
  • Explained
  • Ordering reversal
  • unknown

mRNABench: A curated benchmark for mature mRNA property and function prediction ranks DNABERT-2 above RNA-FM in 7 of 7 comparisons; 2 of 2 other studies rank RNA-FM above DNABERT-2.

2 papers rank RNA-FM above DNABERT-2 in all 30 comparisons that are not ties (4 are ties). MRNABench ranks DNABERT-2 above RNA-FM in all 7 comparisons that are not ties (3 are ties).

Comparisons in which each paper scores RNA-FM or DNABERT-2 higher2 other papers: RNA-FM higher in 30, DNABERT-2 higher in 0, 4 ties. mRNABench (disagrees): RNA-FM higher in 0, DNABERT-2 higher in 7, 3 ties.2 other papers30 RNA-FM higher304 tie4Disagrees: mRNABenchmRNABench: A curated benchmark for mature mRNA property and function prediction3 tie37 DNABERT-2 higher7
RNA-FM higherTieDNABERT-2 higher
Compared
DNABERT-2, RNA-FM

1 follow-up action, latest 23 October 2026

Eigen and MutationAssessor: Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) reverses the order

  • Low severity
  • Explained
  • Ordering reversal
  • unknown

Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML) ranks MutationAssessor above Eigen in 6 of 7 comparisons; 3 of 3 other studies rank Eigen above MutationAssessor.

3 papers rank Eigen above MutationAssessor in 17 of their 22 comparisons and MutationAssessor higher in 1; 4 are ties. Livesey and Marsh 2025 ranks MutationAssessor above Eigen in 6 of its 7 comparisons and Eigen higher in 1.

Comparisons in which each paper scores Eigen or MutationAssessor higher3 other papers: Eigen higher in 17, MutationAssessor higher in 1, 4 ties. Livesey and Marsh 2025 (disagrees): Eigen higher in 1, MutationAssessor higher in 6, 0 ties.3 other papers17 Eigen higher174 tie41 MutationAssessor higherDisagrees: Livesey and Marsh 2025Livesey and Marsh 2025, Genome Biology 26:104 (Europe PMC full text XML)1 Eigen higher16 MutationAssessor higher6
Eigen higherTieMutationAssessor higher
Compared
Eigen, MutationAssessor

1 follow-up action, latest 23 October 2026

RNAErnie and AIDO.RNA: Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning and RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md disagree

  • Low severity
  • Explained
  • two-study-conflict
  • Same task, different protocols

Zero-shot benchmarking of RNA language models in structural, functional, and evolutionary learning ranks AIDO.RNA above RNAErnie in 36 of 36 comparisons; RNAGym fitness leaderboard (v0.1.1), leaderboard/fitness/README.md ranks RNAErnie above AIDO.RNA in 3 of 4 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank RNAErnie above AIDO.RNA in 3 of their 40 comparisons and AIDO.RNA higher in 37. Of those papers, Zero-shot benchmarking of RNA language… ranks AIDO.RNA higher on its own (36 of 36).

Comparisons in which each paper scores RNAErnie or AIDO.RNA higher2 other papers: RNAErnie higher in 3, AIDO.RNA higher in 37, 0 ties.2 other papers3 RNAErnie higher37 AIDO.RNA higher37
RNAErnie higherTieAIDO.RNA higher
Compared
RNAErnie, AIDO.RNA

3 follow-up actions, latest 24 October 2026

ESM-IF1 and ProteinMPNN: ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design and proteinbench primary benchmark evidence disagree

  • Low severity
  • Explained
  • two-study-conflict
  • different-task

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design ranks ESM-IF1 above ProteinMPNN in 19 of 19 comparisons; proteinbench primary benchmark evidence ranks ProteinMPNN above ESM-IF1 in 10 of 10 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank ESM-IF1 above ProteinMPNN in 19 of their 29 comparisons and ProteinMPNN higher in 10. Of those papers, proteinbench primary benchmark evidence ranks ProteinMPNN higher on its own (10 of 10).

Comparisons in which each paper scores ESM-IF1 or ProteinMPNN higher2 other papers: ESM-IF1 higher in 19, ProteinMPNN higher in 10, 0 ties.2 other papers19 ESM-IF1 higher1910 ProteinMPNN higher10
ESM-IF1 higherTieProteinMPNN higher
Compared
ESM-IF1, ProteinMPNN

2 follow-up actions, latest 24 October 2026

ESM3 and ProteinMPNN: ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design and proteinbench primary benchmark evidence disagree

  • Low severity
  • Explained
  • two-study-conflict
  • different-task

ProteinGym: Large-Scale Benchmarks for Protein Fitness Prediction and Design ranks ESM3 above ProteinMPNN in 18 of 19 comparisons; proteinbench primary benchmark evidence ranks ProteinMPNN above ESM3 in 10 of 10 comparisons. No other study gives a verdict, so neither is the outlier.

2 papers rank ESM3 above ProteinMPNN in 18 of their 29 comparisons and ProteinMPNN higher in 11. Of those papers, proteinbench primary benchmark evidence ranks ProteinMPNN higher on its own (10 of 10).

Comparisons in which each paper scores ESM3 or ProteinMPNN higher2 other papers: ESM3 higher in 18, ProteinMPNN higher in 11, 0 ties.2 other papers18 ESM3 higher1811 ProteinMPNN higher11
ESM3 higherTieProteinMPNN higher
Compared
ESM3, ProteinMPNN

2 follow-up actions, latest 24 October 2026

Resolved

Findings the check no longer makes, kept with their follow-up history: usually because a confirmed error led us to withdraw the results involved.