rewire.itbenchmarks
Task

enhancer recognition

Enhancer recognition is evaluated separately from classification of enhancer strength.

SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48

1 evaluation · 1 result

Overview

Datasets

Previously published enhancer/non-enhancer sequences with strong/weak labels for the enhancer subset.

Metrics

Specificity, sensitivity, accuracy, balanced accuracy, MCC and AUC.

Allowed inputs

DNA sequences.

SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48
Evaluation procedure diagram
How it worksComputational evaluation flow
Computational evaluation flow1. Allowed inputs: DNA sequences.. Then: 2. Datasets: Previously published enhancer/non-enhancer sequences with strong/weak labels for the enhancer subset.. Then: 3. Metrics: Specificity, sensitivity, accuracy, balanced accuracy, MCC and AUC.Computational evaluation flow1. Allowed inputs: DNA sequences.. Then: 2. Datasets: Previously published enhancer/non-enhancer sequences with strong/weak labels for the enhancer subset.. Then: 3. Metrics: Specificity, sensitivity, accuracy, balanced accuracy, MCC and AUC.Computational evaluation flow1. Allowed inputs: DNA sequences.. Then: 2. Datasets: Previously published enhancer/non-enhancer sequences with strong/weak labels for the enhancer subset.. Then: 3. Metrics: Specificity, sensitivity, accuracy, balanced accuracy, MCC and AUC.

Conceptual summary of the cited evaluation; exact task configuration and source version remain part of the protocol.

SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48; Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48; Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48

limited source coverage · Automated source review, 2026-09-16. All specifications and missing details

Results

Results are available, but no reviewed comparison panel is linked in this release.

All evaluations

1 evaluation · 1 result. Different protocols are not a single leaderboard.

Filter evaluations

Applied filters: All linked evaluations

Exact evaluated configurations and original reported results
Tested configurationProtocol and datasetFindingEvidence and details
Configuration: DNABERT2-EnhancerTask: enhancer recognition
Dataset: Liu training dataset
0.965 AUC
fraction · unknown

Uncertainty: Not reported

Coverage: Not reported scored / Not reported eligible

Author-reported evaluation · Source checked
Methods, coverage and source

DNABERT2-Enhancer: enhancer recognition

first-layer enhancer versus non-enhancer classifier

Aggregation: Not reported

Utilizing a deep learning model based on BERT for identifying enhancers and their strength · Table 4, first-layer DNABERT2-Enhancer row, AUC column

Source checking is not independent reproduction. Release 2026-09-29-06401fd5b220.

Methods and evaluation design

Procedure, tasks and evaluated configurations

How it works

Evaluation methodology

Previously published enhancer/non-enhancer sequences with strong/weak labels for the enhancer subset. Five-fold cross-validation is performed within Liu’s training data; separately listed test subsets distinguish enhancer detection from enhancer-strength classification. Specificity, sensitivity, accuracy, balanced accuracy, MCC and AUC. The source describes CD-HIT filtering of highly similar sequences. The cited text-accessible evaluation sections give no confidence-interval, resampling or repeat-run error-bar specification. Image-only tables and uninspected supplements are outside this absence claim.

SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48

Recorded evaluations

Each evaluation records what was tested and under which conditions.

Run instructions

No runnable recipe has been reviewed for this task. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.

A task describes a biological question. Choose a linked protocol to obtain concrete split and scoring instructions.

Strengths, limitations and unresolved questions

Strengths and limitations

Strengths and considerations

No source-reviewed explanatory claims are recorded here yet.

Profile review details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Stable record: reported-task-86a628af87ff8f

Specifications

Inputs, training, access and other details

Explanatory profile: limited source coverage · Automated source review, 2026-09-16. Review applies to the cited claims; unresolved fields are listed below. Numerical results retain their own review status.

Data, procedure and scoring
PropertyDescription and evidence
DatasetsPreviously published enhancer/non-enhancer sequences with strong/weak labels for the enhancer subset.
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48
SplitsFive-fold cross-validation is performed within Liu’s training data; separately listed test subsets distinguish enhancer detection from enhancer-strength classification.
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48
MetricsSpecificity, sensitivity, accuracy, balanced accuracy, MCC and AUC.
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48
BaselinesLiu cross-validation compares iEnhancer-ECNN, BERT-Enhancer and iEnhancer-BERT. Its independent test additionally includes EnhancerPred, iEnhancer-EL, iEnhancer-XG and Enhancer-MDLF; not every comparator reports both recognition and strength metrics.
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Results: Comparison with existing methods; Tables 4–5
Leakage controlsThe source describes CD-HIT filtering of highly similar sequences.
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48
UncertaintyThe cited text-accessible evaluation sections give no confidence-interval, resampling or repeat-run error-bar specification. Image-only tables and uninspected supplements are outside this absence claim. · Not reported in inspected sources
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48
Entity typePaper-specific computational evaluation protocol.
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48
OrganismsThe dataset section identifies Liu’s reused enhancer collection and eight Basith cell-line collections, but does not state a species or genome assembly for the Liu collection. These identities cannot be inferred from DNABERT2’s multispecies pretraining. · Not reported in inspected sources
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Materials and methods: Benchmark dataset; Tables 1–2
AssaysEnhancer/non-enhancer and strong/weak enhancer annotations.
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48
Allowed inputsDNA sequences.
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48
AdaptationDNABERT-2 converts sequences to feature matrices; a convolution/pooling module and two-layer perceptron perform supervised enhancer classification. The architecture passage does not specify the encoder freezing boundary.
SourcesUtilizing a deep learning model based on BERT for identifying enhancers and their strength · Methods: DNABERT-2 representation and CNN model, cached paragraphs 36–43

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Papers and result coverage

Last literature check: 2026-09-17. Dated primary-source discovery and protocol/table screening. Source checking does not mean experimental reproduction. Only separately extracted and independently reviewed numeric batches are publishable.

Historical gaps recorded on 2026-09-17

The catalogue now holds 1 result rows for this benchmark. A note below about pending extraction describes the state on 2026-09-17 and may since have been answered by a later batch. The result rows and their sources are the current record.

  • complete numerical transcription and independent cell review: Full primary artifact and table inventory preserved; no new numeric row is published from this audit alone.
  • exact checkpoint hashes and per-method scored denominators: Table labels alone do not establish these fields; do not infer checkpoint or scored count from model name or dataset size.
Search and extraction details

primary comparison tables located

Searches

  • Utilizing a deep learning model based on BERT for identifying enhancers and their strength 10.1371/journal.pone.0320085

Evidence locations

  • Table 4; XML table pone.0320085.t004
  • Table 5; XML table pone.0320085.t005
  • Table 6; XML table pone.0320085.t006

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

17 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-09-29-06401fd5b220
Property and statementOriginal source and locationReview and provenance
Diagram caption
Conceptual summary of the cited evaluation; exact task configuration and source version remain part of the protocol.
Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48; Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48; Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.diagram.caption

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram steps
  • Allowed inputs: DNA sequences.
  • Datasets: Previously published enhancer/non-enhancer sequences with strong/weak labels for the enhancer subset.
  • Metrics: Specificity, sensitivity, accuracy, balanced accuracy, MCC and AUC.
Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48; Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48; Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.diagram.steps

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Diagram title
Computational evaluation flow
Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48; Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48; Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.diagram.title

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Datasets
Previously published enhancer/non-enhancer sequences with strong/weak labels for the enhancer subset.
Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.0.value

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Splits
Five-fold cross-validation is performed within Liu’s training data; separately listed test subsets distinguish enhancer detection from enhancer-strength classification.
Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.1.value

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Adaptation
DNABERT-2 converts sequences to feature matrices; a convolution/pooling module and two-layer perceptron perform supervised enhancer classification. The architecture passage does not specify the encoder freezing boundary.
Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Methods: DNABERT-2 representation and CNN model, cached paragraphs 36–43

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.10.value

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Metrics
Specificity, sensitivity, accuracy, balanced accuracy, MCC and AUC.
Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.2.value

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Baselines
Liu cross-validation compares iEnhancer-ECNN, BERT-Enhancer and iEnhancer-BERT. Its independent test additionally includes EnhancerPred, iEnhancer-EL, iEnhancer-XG and Enhancer-MDLF; not every comparator reports both recognition and strength metrics.
Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Results: Comparison with existing methods; Tables 4–5

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.3.value

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Leakage controls
The source describes CD-HIT filtering of highly similar sequences.
Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

source checked

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.4.value

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Uncertainty
The cited text-accessible evaluation sections give no confidence-interval, resampling or repeat-run error-bar specification. Image-only tables and uninspected supplements are outside this absence claim.
Individual claims
Utilizing a deep learning model based on BERT for identifying enhancers and their strength

Original source ↗

Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48

Version: journal full text in PMC
Retrieved: 2026-09-16T10:38:57.558204+00:00

unreported

automated source review · 2026-09-16

Audit details

Relevant full-paper computational evaluation sections, tables/captions and cited supplementary task passages were reviewed. Reporting omissions are scoped to the inspected sources. Original numerical results are unchanged.

Field: attributes.profile.facts.5.value

Source artifact SHA-256: d052b80efe7bfc1380994ad28503a5575f04ef940f74d5c9c137cb4ba6827863

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Sources and history

View linked audit checks and correction history

Release 2026-09-29-06401fd5b220 · Record review: needs review

2 source records and release historyDownload this release
Technical metadata and extraction receipts

Stable ID: reported-task-86a628af87ff8f

areas
dna-genomes
tasks
enhancer recognition
entity level
task
version
Not reported
task
enhancer recognition
scope note
Paper-specific evaluation task; protocol completeness requires further extraction.
benchmark research
review date: 2026-09-17; status: primary_comparison_tables_located; primary sources: evidence-expansion-dnabert2-enhancer-2025-d052b80e; inspected locators: Table 4; XML table pone.0320085.t004; Table 5; XML table pone.0320085.t005; Table 6; XML table pone.0320085.t006; searched queries: Utilizing a deep learning model based on BERT for identifying enhancers and their strength 10.1371/journal.pone.0320085; gaps: complete numerical transcription and independent cell review: Full primary artifact and table inventory preserved; no new numeric row is published from this audit alone.; exact checkpoint hashes and per-method scored denominators: Table labels alone do not establish these fields; do not infer checkpoint or scored count from model name or dataset size.; claim scope: Dated primary-source discovery and protocol/table screening. Source checking does not mean experimental reproduction. Only separately extracted and independently reviewed numeric batches are publishable.
historical missing metadata
protocol version: not_reported_in_legacy_extract
metadata review scope
historical_missing_metadata preserves the original discovery state. Current descriptive evidence and missingness are recorded in profile.facts; numerical-result review is separate.
legacy kinds
benchmark
entity classification
review date: 2026-09-17; rationale: This source-scoped record identifies the biological prediction task and holds its paper context. Preserve the existing task identity; exact split, model adaptation and scoring remain in linked evaluations or separate protocol records.; source ids: dnabert2-enhancer-2025; source locator: Methods: Benchmark dataset; Performance evaluation metrics; cached text lines 12–13, 47–48; ambiguities: A paper- or suite-specific task may constrain some inputs or metrics; that alone does not make it interchangeable with a complete versioned protocol. No protocol equivalence is inferred.; Some legacy profile Entity type facts use the generic phrase computational evaluation protocol. That boilerplate is not sufficient to establish a single fixed protocol identity or to merge this task with another protocol record.
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