Result

Spearman (ProteinGym zero-shot DMS substitutions, Human proteins: mean over proteins of assay-level Spearman) of SaProt (650M) [ProteinGym 144fe22b snapshot] on ProteinGym DMS substitution assays at commit 144fe22 (217 assays)

0.478 Spearman (ProteinGym zero-shot DMS substitutions, Human proteins: mean over proteins of assay-level Spearman)

Methods

Tested configuration: SaProt (650M) [ProteinGym 144fe22b snapshot]
Protocol: ProteinGym v1.3 zero-shot DMS substitutions
Dataset subset: ProteinGym DMS substitution assays at commit 144fe22 (217 assays)
Related family profiles: SaProt
Procedure: ProteinGym zero-shot DMS substitutions, Spearman summary
Evaluation: SaProt (650M): ProteinGym zero-shot DMS substitutions summary (144fe22)
Coverage: Not reported scored / Not reported eligible
Uncertainty: Not reported by the source
Evidence: Evaluation origin not reported · source checkedProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 18, row 'SaProt (650M)', column 'Taxa_Human'

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.

Reproduction

Split: Not reported
Adaptation: Zero-shot; no assay labels used
Scoring implementation: Spearman per assay (performance_DMS_benchmarks.py at 144fe22)

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Reported result 0.478 Individual claims	ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 Original source ↗ benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 18, row 'SaProt (650M)', column 'Taxa_Human' Version: 144fe22b07dfaeec2b366f2346203a9838a55b4c Retrieved: 2026-10-14T13:39:32Z	source checked ["source-hash-verification","deterministic-table-parse","independent-cell-check"] · 2026-10-14T15:30:00Z unreported Audit details Extracted by extract/extract_vep.py; independently re-checked by review/check_values.py. Value, metric and identity match the source. Field: `attributes.printed_value` Source artifact SHA-256: `ee61a7c09efbfbd8d9a6c9355092c798032a578fa58c6f6256b5da8778555fd4` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact Extraction artifact SHA-256: `ee61a7c09efbfbd8d9a6c9355092c798032a578fa58c6f6256b5da8778555fd4` Extraction artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

2 source records and release history

ProteinGym zero-shot DMS substitutions Spearman summary at commit 144fe22 · Original source · 144fe22b07dfaeec2b366f2346203a9838a55b4c
Protocol metadata evidence: proteingym-proteingym-performance_DMS_benchmarks.py · Original source · 144fe22b07dfaeec2b366f2346203a9838a55b4c

Download this release (gzip)

Technical metadata and extraction receipts

Stable ID: vep-lit-20261014-result-pg-dms-saprot-650m-taxa-human

metric: spearman-correlation
metric direction: higher
unit: unitless
metric qualifier: ProteinGym zero-shot DMS substitutions, Human proteins: mean over proteins of assay-level Spearman
printed value: 0.478
numeric value: 0.478
source locator: benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv line 18, row 'SaProt (650M)', column 'Taxa_Human'
review: reviewer: claude; reviewer note: Claude review agent; no human review claimed. Independent Claude (Opus 5.5) review agent, separate from the extraction agent that built this batch. Automated review only. Transcription, not reproduction.; reviewed at: 2026-10-14T15:30:00Z; artifact sha256: ee61a7c09efbfbd8d9a6c9355092c798032a578fa58c6f6256b5da8778555fd4; retrieval url: https://raw.githubusercontent.com/OATML-Markslab/ProteinGym/144fe22b07dfaeec2b366f2346203a9838a55b4c/benchmarks/DMS_zero_shot/substitutions/Spearman/Summary_performance_DMS_substitutions_Spearman.csv; method: source-hash-verification; deterministic-table-parse; independent-cell-check; method note: Re-downloaded the CSV from raw.githubusercontent.com at 144fe22 and matched the pinned SHA-256. review/check_values.py re-read it with the csv module and checked printed and numeric value, CSV line, Model_name, column, metric, qualifier, unit, direction, uncertainty and the linked configuration and protocol; all 1,794 ProteinGym results matched.; note: Extracted by extract/extract_vep.py; independently re-checked by review/check_values.py. Value, metric and identity match the source.
missing metadata: uncertainty: reason: unreported

Related records

evaluation: SaProt (650M): ProteinGym zero-shot DMS substitutions summary (144fe22)

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