Result

0.701 pearson-correlation

tang2025-k562-lentimpra-embedding-cnn-sei-pearson pearson-correlation

Tested configuration: CNN-SEI, LentiMPRA-embedding (Tang et al. 2025)
Protocol: CAGI5 saturation MPRA variant effect correlation, K562 (Tang et al. 2025 Table 1)
Dataset: CAGI5 saturation mutagenesis MPRA, four CREs (as used by Tang et al. 2025)
Procedure: regulatory-variant-20261009-protocol-tang2025-cagi5-k562
Evaluation: CNN-SEI (LentiMPRA-embedding) on CAGI5 K562
Coverage: Not reported scored / Not reported eligible
Uncertainty: Not reported by the source
Evidence: Author-reported evaluation · source checkedEvaluating the representational power of pre-trained DNA language models for regulatory genomics · Table 1 row 'LentiMPRA-embedding' / 'CNN-SEI', column 'K562'

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.

Reproduction

Split: Zero-shot test
Adaptation: CNN trained by the authors on lentiMPRA activity using frozen embeddings of the named model
Scoring implementation: Pearson correlation per experiment

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Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-10-10-6e93f504adfc
Property and statement	Original source and location	Review and provenance
Reported result 0.701 Individual claims	Evaluating the representational power of pre-trained DNA language models for regulatory genomics Original source ↗ Table 1 row 'LentiMPRA-embedding' / 'CNN-SEI', column 'K562' Version: Genome Biology 26:203, published 2025-07-14; PMC12261763 full-text XML Retrieved: 2026-10-09T21:04:28Z	source checked ["source-hash-verification","deterministic-table-parse","independent-cell-check"] · 2026-10-09 author reported Audit details Deterministic parse of the pinned article XML table (extract/extract_regulatory_variant.py) with caption, column headers and row labels asserted. Pending independent review. Independent review 2026-10-09: value, interval or standard error, and identity match the source. Field: `attributes.printed_value` Source artifact SHA-256: `f6925cc2d93d0694ccc689970207c2df9b7b0d2562d276ede99f0c78d413b08b` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact Extraction artifact SHA-256: `f6925cc2d93d0694ccc689970207c2df9b7b0d2562d276ede99f0c78d413b08b` Extraction artifact

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Sources and history

Release 2026-10-10-6e93f504adfc · Record review: source checked

1 source records and release history

Evaluating the representational power of pre-trained DNA language models for regulatory genomics · Original source · Genome Biology 26:203, published 2025-07-14; PMC12261763 full-text XML

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Technical metadata and extraction receipts

Stable ID: regulatory-variant-20261009-result-tang2025-k562-lentimpra-embedding-cnn-sei-pearson

metric: pearson-correlation
metric direction: higher
unit: unitless
printed value: 0.701
numeric value: 0.701
source locator: Table 1 row 'LentiMPRA-embedding' / 'CNN-SEI', column 'K562'
review: method: source-hash-verification; deterministic-table-parse; independent-cell-check; method note: Re-downloaded the article XML and matched its SHA-256. Read Table 1 with the reviewer's own table-wrap reader, resolving the row-spanning Training task cells; checked printed and numeric value, column, task and model labels and linked configuration and protocol.; reviewer: claude; reviewer note: Separate Claude review agent, independent of the extractor; no human review claimed; date: 2026-10-09; artifact sha256: f6925cc2d93d0694ccc689970207c2df9b7b0d2562d276ede99f0c78d413b08b; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12261763/fullTextXML; note: Deterministic parse of the pinned article XML table (extract/extract_regulatory_variant.py) with caption, column headers and row labels asserted. Pending independent review. Independent review 2026-10-09: value, interval or standard error, and identity match the source.
missing metadata: uncertainty: reason: unreported
metric qualifier: predicted versus MPRA-measured saturation mutagenesis variant effect; one CRE

Related records

evaluation: CNN-SEI (LentiMPRA-embedding) on CAGI5 K562

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