Result

Spearman (mean over assays) of ProteinMPNN on ProteinGym substitution DMS: stability assays

0.566 Spearman (mean over assays)

Methods

Tested configuration: ProteinMPNN
Task: Zero-shot substitution mutation effects: stability
Dataset: ProteinGym substitution DMS: stability assays
Related family profiles: ProteinMPNN
Procedure: Zero-shot mutation scores; average Spearman across stability-category assays.
Evaluation: ProteinMPNN: Zero-shot substitution mutation effects: stability
Coverage: Not reported scored / Not reported eligible
Uncertainty: Not yet extracted
Evidence: Independent external evaluation · source checkedProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction · Table A7, ProteinMPNN row, Stability column

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: needs review. Source checked does not mean independently reproduced.

Reproduction

Split: Not reported
Adaptation: Not reported
Scoring implementation: Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-11-02-a7f03c9e55a5
Property and statement	Original source and location	Review and provenance
Printed value 0.566 Individual claims	ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction Original source ↗ Table A7, ProteinMPNN row, Stability column Version: PMC10723403.1 Retrieved: 2026-09-16T10:41:16.517323+00:00	source checked ["ai-assisted-source-review"] · 2026-09-16T10:41:16.523422+00:00 independent paper Audit details Table A7 is zero-shot substitution DMS grouped by function. Stability is the fifth numeric column; model-type row spans do not change its placement. This verifies the central score at its source location, not every metadata field or an experimental reproduction. Field: `attributes.printed_value` Claim: claim-lit-018 Source artifact SHA-256: `4519641f13271bdd09b166e7d93232f22542489bc52a25b5a1628c3df8badce1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact Extraction artifact SHA-256: `4519641f13271bdd09b166e7d93232f22542489bc52a25b5a1628c3df8badce1` Extraction artifact

How to read the evidence

Sources and history

Release 2026-11-02-a7f03c9e55a5 · Record review: source checked

1 source record and release history

ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction · Original source · PMC10723403.1

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Technical metadata and extraction receipts

Stable ID: lit-018

areas: proteins-complexes
tasks: Zero-shot substitution mutation effects: stability
printed value: 0.566
numeric value: 0.566
metric: spearman-correlation
metric direction: unknown
unit: unitless
source locator: Table A7, ProteinMPNN row, Stability column
review: method: ai-assisted-source-review; reviewer: codex; reviewed at: 2026-09-16T10:41:16.523422+00:00; evidence: {"table_xml_id": "T11", "row_cells": ["ProteinMPNN", "0.197", "0.165", "0.198", "0.165", "0.566", "0.258"], "selected_cell_zero_based": 5, "selected_cell_xml": "<td align=\"center\" valign=\"top\" rowspan=\"1\" colspan=\"1\">0.566</td>", "caption": "ProteinGym - Zero-shot substitution DMS benchmark by function typeAverage Spearman’s rank correlation between model scores and experimental measurements on the ProteinGym substitution benchmark, separated into five functional categories (Activity, Binding, Organismal Fitness, Stability and Expression). ‘All’ is the average of all the categories."}; artifact sha256: 4519641f13271bdd09b166e7d93232f22542489bc52a25b5a1628c3df8badce1; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10723403/fullTextXML; method note: independent; table-level review; reviewer note: role: omics research agent; independent source-table review; not human review; note: Table A7 is zero-shot substitution DMS grouped by function. Stability is the fifth numeric column; model-type row spans do not change its placement. This verifies the central score at its source location, not every metadata field or an experimental reproduction.
legacy id: lit-018
missing metadata: dataset version: reason: unextracted; model version: reason: unextracted; split: reason: unextracted; uncertainty: reason: unextracted
metric qualifier: mean over assays

Related records

evaluation: ProteinMPNN: Zero-shot substitution mutation effects: stability
subject: Reported Mean Spearman rho for ProteinMPNN

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