Result

0.488 Mean Spearman rho

ESM-2 · Mean Spearman rho · ProteinGym substitution DMS: stability assays

Tested configuration: ESM-2
Task: Zero-shot substitution mutation effects: stability
Dataset: ProteinGym substitution DMS: stability assays
Related family profiles: ESM-2
Procedure: Zero-shot mutation scores; average Spearman across stability-category assays.
Evaluation: ESM-2: Zero-shot substitution mutation effects: stability
Coverage: scored: unreported; eligible: unreported
Uncertainty: Not reported
Evidence: Independent external evaluation · source checkedProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction · Table A7, ESM-2 (15B) row, Stability column

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: needs review. Source checked does not mean independently reproduced.

Reproduction

Split: Not reported
Adaptation: Not reported
Scoring implementation: Not reported

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Access requirements and official instructions: Zero-shot substitution mutation effects: stability

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-09-29-06401fd5b220
Property and statement	Original source and location	Review and provenance
attributes.printed_value 0.488 Individual claims	ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction Original source ↗ Table A7, ESM-2 (15B) row, Stability column Version: PMC10723403.1 Retrieved: 2026-09-16T10:41:16.517323+00:00	source checked independent ai table review · 2026-09-16T10:41:16.517323+00:00 independent paper Audit details Table A7 is zero-shot substitution DMS grouped by function. Stability is the fifth numeric column; model-type row spans do not change its placement. This verifies the central score at its source location, not every metadata field or an experimental reproduction. Field: `attributes.printed_value` Claim: claim-lit-017 Source artifact SHA-256: `4519641f13271bdd09b166e7d93232f22542489bc52a25b5a1628c3df8badce1` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact Extraction artifact SHA-256: `4519641f13271bdd09b166e7d93232f22542489bc52a25b5a1628c3df8badce1` Extraction artifact

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Release 2026-09-29-06401fd5b220 · Record review: source checked

1 source records and release history

ProteinGym: Large-Scale Benchmarks for Protein Design and Fitness Prediction · Original source · PMC10723403.1

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Technical metadata and extraction receipts

Stable ID: lit-017

areas: proteins-complexes
tasks: Zero-shot substitution mutation effects: stability
printed value: 0.488
numeric value: 0.488
metric: Mean Spearman rho
metric direction: unknown
unit: unitless
uncertainty: Not reported
source locator: Table A7, ESM-2 (15B) row, Stability column
review: method: independent_ai_table_review; reviewer: Codex omics research agent; independent source-table review, not human review; reviewed at: 2026-09-16T10:41:16.517323+00:00; notes: Table A7 is zero-shot substitution DMS grouped by function. Stability is the fifth numeric column; model-type row spans do not change its placement. This verifies the central score at its source location, not every metadata field or an experimental reproduction.; evidence: {"table_xml_id": "T11", "row_cells": ["ESM-2 (15B)", "0.405", "0.318", "0.425", "0.388", "0.488", "0.405"], "selected_cell_zero_based": 5, "selected_cell_xml": "<td align=\"center\" valign=\"top\" rowspan=\"1\" colspan=\"1\">0.488</td>", "caption": "ProteinGym - Zero-shot substitution DMS benchmark by function typeAverage Spearman’s rank correlation between model scores and experimental measurements on the ProteinGym substitution benchmark, separated into five functional categories (Activity, Binding, Organismal Fitness, Stability and Expression). ‘All’ is the average of all the categories."}; artifact sha256: 4519641f13271bdd09b166e7d93232f22542489bc52a25b5a1628c3df8badce1; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC10723403/fullTextXML
legacy id: lit-017
legacy row: id: lit-017; paper id: proteingym-2023; domain id: proteins-complexes; task: Zero-shot substitution mutation effects: stability; model: ESM-2; model version: 15B; dataset: ProteinGym substitution DMS: stability assays; dataset version: Not reported; split: Not reported; metric: Mean Spearman rho; value: 0.488; unit: unitless; uncertainty: Not reported; protocol: Zero-shot mutation scores; average Spearman across stability-category assays.; source locator: Table A7, ESM-2 (15B) row, Stability column; source url: https://pmc.ncbi.nlm.nih.gov/articles/PMC10723403/; evaluation origin: independent_paper; reviewed utc: 2026-09-15T23:25:00Z
missing metadata: dataset version: not_reported_in_legacy_extract; split: not_reported_in_legacy_extract; uncertainty: not_reported_in_legacy_extract

Related records

evaluation: ESM-2: Zero-shot substitution mutation effects: stability
subject: Reported Mean Spearman rho for ESM-2

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