AUROC (Discrimination of measured binders from high-ranking docking false positives in the tested sigma-2 receptor hit list) of AF3 L-pLDDT (Kim, Correy, Hall et al. 2026 hit-list re-ranking) on Sigma-2 receptor docking hit list, 506 tested compounds
AUC = 56.1 AUROC (Discrimination of measured binders from high-ranking docking false positives in the tested sigma-2 receptor hit list)
Methods
- Tested configuration
- AF3 L-pLDDT (Kim, Correy, Hall et al. 2026 hit-list re-ranking)
- Protocol
- Re-ranking the Sigma-2 receptor docking hit list by co-folding and docking scores (Kim, Correy, Hall et al. 2026)
- Dataset
- Sigma-2 receptor docking hit list, 506 tested compounds
- Procedure
- Re-ranking the Sigma-2 receptor docking hit list by co-folding and docking scores (Kim, Correy, Hall et al. 2026)
- Evaluation
- AF3 L-pLDDT re-ranking the sigma-2 receptor docking hit list (Kim, Correy, Hall et al. 2026)
- Coverage
- Not reported scored / Not reported eligible
- Uncertainty
- Not reported by the source: The source prints no interval or spread for this value
- Evidence
- Author-reported evaluation · source checkedKim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) · Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset; printed in the body text as 'AUC = 56.1'
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- Whole tested list; no training or test split applies
- Adaptation
- None; pretrained models and the published docking receptor
- Scoring implementation
- Area under the receiver operating characteristic curve for separating true hits from non-binders, printed as a percentage
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result AUC = 56.1 Individual claims | Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset; printed in the body text as 'AUC = 56.1' Version: PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12) | source checked ["independent-cell-check","pdf-text-parse"] · 2026-10-22 author reported Audit detailsChecked against the pinned source by an automated independent re-parse. Transcription checked; not reproduced and not reviewed by a human scientist. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Extraction artifact SHA-256: |
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) · Original source · PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12)
Technical metadata and extraction receipts
Stable ID: hitdisc-20261022-result-kim-sigma2-kim-af3-lplddt-auc
- metric
- auroc
- metric direction
- higher
- unit
- unitless
- metric qualifier
- Discrimination of measured binders from high-ranking docking false positives in the tested sigma-2 receptor hit list
- printed value
- AUC = 56.1
- numeric value
- 56.1
- source locator
- Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on the sigma-2 dataset; printed in the body text as 'AUC = 56.1'
- missing metadata
- uncertainty: reason: unreported; note: The source prints no interval or spread for this value
- review
- method: independent-cell-check; pdf-text-parse; reviewer: claude; reviewer note: Claude review agent, independent of the extraction agent; no human review claimed; date: 2026-10-22; method note: Re-downloaded the pinned Europe PMC XML, matched its SHA-256, confirmed it holds no table-wrap element, and checked that each printed AUC string occurs verbatim in the Results section 'Co-folding struggles to reliably re-rank docking hit lists'. No figure was read.; note: Checked against the pinned source by an automated independent re-parse. Transcription checked; not reproduced and not reviewed by a human scientist.; artifact sha256: 9be510b7b0cc152ff56a03c96877bf06b6a6bdeffdb4baecf8e999a6bf155aa6; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13657626/fullTextXML; receipt: data/omics/use-case-coverage-hitdisc-20261022/review.json
- unit detail
- printed as a percentage on a 0-100 scale
- denominator
- 506
- numerator
- 201
- denominator note
- 201 true hits (apparent Ki below 2.0 uM) and 305 non-binders, which are high-ranking docking false positives