Result

AUROC (Discrimination of measured binders from high-ranking docking false positives in the tested AmpC beta-lactamase hit list) of AF3 L-pLDDT (Kim, Correy, Hall et al. 2026 hit-list re-ranking) on AmpC beta-lactamase docking hit list, 1293 tested compounds

AUC = 60.5 AUROC (Discrimination of measured binders from high-ranking docking false positives in the tested AmpC beta-lactamase hit list)

Methods

Tested configuration: AF3 L-pLDDT (Kim, Correy, Hall et al. 2026 hit-list re-ranking)
Protocol: Re-ranking the AmpC beta-lactamase docking hit list by co-folding and docking scores (Kim, Correy, Hall et al. 2026)
Dataset: AmpC beta-lactamase docking hit list, 1293 tested compounds
Procedure: Re-ranking the AmpC beta-lactamase docking hit list by co-folding and docking scores (Kim, Correy, Hall et al. 2026)
Evaluation: AF3 L-pLDDT re-ranking the AmpC beta-lactamase docking hit list (Kim, Correy, Hall et al. 2026)
Coverage: Not reported scored / Not reported eligible
Uncertainty: Not reported by the source: The source prints no interval or spread for this value
Evidence: Author-reported evaluation · source checkedKim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) · Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on AmpC; printed in the body text as 'AUC = 60.5'

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.

Reproduction

Split: Whole tested list; no training or test split applies
Adaptation: None; pretrained models and the published docking receptor
Scoring implementation: Area under the receiver operating characteristic curve for separating true hits from non-binders, printed as a percentage

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

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1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statement	Original source and location	Review and provenance
Reported result AUC = 60.5 Individual claims	Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) Original source ↗ Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on AmpC; printed in the body text as 'AUC = 60.5' Version: PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12) Retrieved: 2026-10-22T11:52:32Z	source checked ["independent-cell-check","pdf-text-parse"] · 2026-10-22 author reported Audit details Checked against the pinned source by an automated independent re-parse. Transcription checked; not reproduced and not reviewed by a human scientist. Field: `attributes.printed_value` Source artifact SHA-256: `9be510b7b0cc152ff56a03c96877bf06b6a6bdeffdb4baecf8e999a6bf155aa6` Hash scope: Hash scope not separately documented; inspect source record Extraction artifact SHA-256: `9be510b7b0cc152ff56a03c96877bf06b6a6bdeffdb4baecf8e999a6bf155aa6` Extraction artifact

How to read the evidence

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

1 source record and release history

Kim, Correy, Hall et al. 2026, eLife 15:RP110475 (Europe PMC full text) · Original source · PMC13657626 (eLife 2026;15:RP110475, version of record published 2026-10-12)

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Technical metadata and extraction receipts

Stable ID: hitdisc-20261022-result-kim-ampc-kim-af3-lplddt-auc

metric: auroc
metric direction: higher
unit: unitless
metric qualifier: Discrimination of measured binders from high-ranking docking false positives in the tested AmpC beta-lactamase hit list
printed value: AUC = 60.5
numeric value: 60.5
source locator: Results 'Co-folding struggles to reliably re-rank docking hit lists', paragraph on AmpC; printed in the body text as 'AUC = 60.5'
missing metadata: uncertainty: reason: unreported; note: The source prints no interval or spread for this value
review: method: independent-cell-check; pdf-text-parse; reviewer: claude; reviewer note: Claude review agent, independent of the extraction agent; no human review claimed; date: 2026-10-22; method note: Re-downloaded the pinned Europe PMC XML, matched its SHA-256, confirmed it holds no table-wrap element, and checked that each printed AUC string occurs verbatim in the Results section 'Co-folding struggles to reliably re-rank docking hit lists'. No figure was read.; note: Checked against the pinned source by an automated independent re-parse. Transcription checked; not reproduced and not reviewed by a human scientist.; artifact sha256: 9be510b7b0cc152ff56a03c96877bf06b6a6bdeffdb4baecf8e999a6bf155aa6; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC13657626/fullTextXML; receipt: data/omics/use-case-coverage-hitdisc-20261022/review.json
unit detail: printed as a percentage on a 0-100 scale
denominator: 1293
numerator: 247
denominator note: 247 true hits (apparent Ki below 400 uM) and 1046 non-binders, which are high-ranking docking false positives

Related records

evaluation: AF3 L-pLDDT re-ranking the AmpC beta-lactamase docking hit list (Kim, Correy, Hall et al. 2026)

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