rewirebio.iobenchmarks
Result

AUROC (ClinVar indels, all strata (Overall row); supervised on indels) of NTv3 650M layer-11 embedding probe (Pearce et al. 2026 Figure 1d) on EVEE ClinVar indel benchmark (73,961 indels)

0.828 AUROC (ClinVar indels, all strata (Overall row); supervised on indels)

Methods

Tested configuration
NTv3 650M layer-11 embedding probe (Pearce et al. 2026 Figure 1d)
Protocol
EVEE ClinVar indel pathogenicity AUROC (Pearce et al. 2026 Figure 1d)
Dataset
EVEE ClinVar indel benchmark (73,961 indels)
Procedure
EVEE ClinVar indel pathogenicity AUROC (Pearce et al. 2026 Figure 1d)
Evaluation
NTv3 on the EVEE ClinVar indel benchmark (Pearce et al. 2026)
Coverage
Not reported scored / Not reported eligible
Uncertainty
Not reported by the source
Evidence
Independent external evaluation · source checkedInterpretable variant effect prediction from genomic foundation model representations (EVEE), bioRxiv v4; EVEE manuscript repository: figures/figure1/fig1d_indel_heatmap.pdf; EVEE manuscript repository: scripts/figure1/fig1d_indel_heatmap.py · Figure 1d (page 3, raster; matched to repository figures/figure1/fig1d_indel_heatmap.pdf text layer), row 'Overall (n=73,961, 65.1%P)', column 'NTv3'

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.

Reproduction

Split
Not reported
Adaptation
supervised on indels
Scoring implementation
Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

Source checking verifies the cited claim or transcription. It does not establish independent reproduction.

Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

3 evidence rows matching the loaded filters

Claims, original sources and review scope · Release 2026-10-22-1b7cf027e4f6
Property and statementOriginal source and locationReview and provenance
Reported result
0.828
Individual claims
EVEE manuscript repository: figures/figure1/fig1d_indel_heatmap.pdf

Original source ↗

Figure 1d (page 3, raster; matched to repository figures/figure1/fig1d_indel_heatmap.pdf text layer), row 'Overall (n=73,961, 65.1%P)', column 'NTv3'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: goodfire-ai/evee-manuscript commit e5e4a43d60bb217819144c09ab509ed44f49cd5f
Retrieved: 2026-10-14T12:48:26Z

source checked

["source-hash-verification","pdf-text-parse","rendered-source-visual-check","independent-cell-check"] · 2026-10-14

independent paper

Audit details

Value matches. Transcribed, not reproduced. Baseline run by the EVEE authors, who did not develop it; independent_paper accepted.

Field: attributes.printed_value

Source artifact SHA-256: b1ec938f98392f1b169798f0d9232337d0635ee909e103745151c0c572578136

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Extraction artifact SHA-256: 1d65b07059c50e8e3f88b8fde950f011630886097bf2784a6653282c6424eef8

Extraction artifact

Reported result
0.828
Individual claims
EVEE manuscript repository: scripts/figure1/fig1d_indel_heatmap.py

Original source ↗

Figure 1d (page 3, raster; matched to repository figures/figure1/fig1d_indel_heatmap.pdf text layer), row 'Overall (n=73,961, 65.1%P)', column 'NTv3'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: goodfire-ai/evee-manuscript commit e5e4a43d60bb217819144c09ab509ed44f49cd5f
Retrieved: 2026-10-14T12:48:26Z

source checked

["source-hash-verification","pdf-text-parse","rendered-source-visual-check","independent-cell-check"] · 2026-10-14

independent paper

Audit details

Value matches. Transcribed, not reproduced. Baseline run by the EVEE authors, who did not develop it; independent_paper accepted.

Field: attributes.printed_value

Source artifact SHA-256: 5c03755c6807fef579e234676d86b9e6a20d675e0d520e656e8a60615331e34d

Hash scope: Hash scope not separately documented; inspect source record

Inspected artifact

Extraction artifact SHA-256: 1d65b07059c50e8e3f88b8fde950f011630886097bf2784a6653282c6424eef8

Extraction artifact

Reported result
0.828
Individual claims
Interpretable variant effect prediction from genomic foundation model representations (EVEE), bioRxiv v4

Original source ↗

Figure 1d (page 3, raster; matched to repository figures/figure1/fig1d_indel_heatmap.pdf text layer), row 'Overall (n=73,961, 65.1%P)', column 'NTv3'

Shared locator for this statement’s cited sources; not a separate locator for each citation.

Version: bioRxiv v4, posted 2026-07-11 (v1 posted 2026-04-11)
Retrieved: 2026-10-14T12:02:25Z

source checked

["source-hash-verification","pdf-text-parse","rendered-source-visual-check","independent-cell-check"] · 2026-10-14

independent paper

Source has a recorded evidence concern. Consult its source page before using the claim.

Audit details

Value matches. Transcribed, not reproduced. Baseline run by the EVEE authors, who did not develop it; independent_paper accepted.

Field: attributes.printed_value

Source artifact SHA-256: 1d65b07059c50e8e3f88b8fde950f011630886097bf2784a6653282c6424eef8

Hash scope: SHA-256 of one retrieval of the bioRxiv PDF (2026-10-14T12:02:25Z). bioRxiv stamps the PDF on each download (XMP ModifyDate, MetadataDate, DocumentID and InstanceID, the Info ModDate and the trailer /ID), so later retrievals differ. The extractor's copy was not retained, so the pinned bytes could not be re-verified. The independent reviewer's retrieval on 2026-10-14 (5,466,701 bytes, 26 pages, ModDate D:20261014063735-07'00') had SHA-256 9e2176440dfae6740b9e799796297cdd70b9bd59edb5c0a1e7fcdb5d6978710a; its Figure 1c and 1d match the repository vector PDFs cell for cell in the Overall rows, and the quoted Methods and Competing interests sentences are present.

Inspected artifact

Extraction artifact SHA-256: 1d65b07059c50e8e3f88b8fde950f011630886097bf2784a6653282c6424eef8

Extraction artifact

Sources and history

Release 2026-10-22-1b7cf027e4f6 · Record review: source checked

3 source records and release historyDownload this release (gzip)
Technical metadata and extraction receipts

Stable ID: gfm-guide-20261014-result-evee-indel-ntv3-subref-probe

metric
auroc
metric direction
higher
unit
unitless
printed value
0.828
numeric value
0.828
source locator
Figure 1d (page 3, raster; matched to repository figures/figure1/fig1d_indel_heatmap.pdf text layer), row 'Overall (n=73,961, 65.1%P)', column 'NTv3'
missing metadata
uncertainty: reason: unreported
review
method: source-hash-verification; pdf-text-parse; rendered-source-visual-check; independent-cell-check; method note: Overall row parsed by the reviewer's own script (review/check_gfm_guide.py) from the repository vector PDF of Figure 1d (SHA-256 matches the pinned record), column order taken from the pinned plotting code and checked against a 300 dpi render of page 3 of a fresh copy of the paper (SHA-256 9e2176440dfae6740b9e799796297cdd70b9bd59edb5c0a1e7fcdb5d6978710a; bioRxiv stamps each download, see the source's hash_scope).; reviewer: claude; reviewer note: Independent Claude (Opus 5.5) review agent for PR #150; did not extract this batch; no human review claimed; date: 2026-10-14; artifact sha256: 1d65b07059c50e8e3f88b8fde950f011630886097bf2784a6653282c6424eef8; retrieval url: https://www.biorxiv.org/content/biorxiv/early/2026/07/11/2026.04.10.717844.full.pdf; note: Value matches. Transcribed, not reproduced. Baseline run by the EVEE authors, who did not develop it; independent_paper accepted.
metric qualifier
ClinVar indels, all strata (Overall row); supervised on indels
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