Result

0.923 auroc

hou2024-t1-fsd-pca auroc (pan-cancer vs healthy; mean of 10 x 10-fold cross-validation)

Tested configuration: Fragment size distribution (FSD), open chromatin regions after PCA dimension reduction, SVM (Hou et al. 2024)
Protocol: Hou et al. 2024 pan-cancer vs healthy, Cristiano cohort, 10 x 10-fold cross-validation (Table 1 AUC)
Dataset: DELFI 2019 internally cross-validated cancer detection cohort
Procedure: ctdnafrag-20261009-protocol-hou2024-cristiano-pancan-cv-auc
Evaluation: FSD (open chromatin regions after PCA dimension reduction), pan-cancer vs healthy AUC
Coverage: Not reported scored / Not reported eligible
Uncertainty: 95% CI 0.9149 to 0.9308
Evidence: Independent external evaluation · source checkedSystematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns · Article Table 1 (advs8741-tbl-0001), row 'FSD', column 'after PCA degradation'

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.

Reproduction

Split: 10 repeats of 10-fold cross-validation
Adaptation: SVM trained per fold
Scoring implementation: Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

Inspect claims, sources and review details

Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

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1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-10-09-ba02f2f4a36e
Property and statement	Original source and location	Review and provenance
Reported result 0.9229 Individual claims	Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns Original source ↗ Article Table 1 (advs8741-tbl-0001), row 'FSD', column 'after PCA degradation' Version: Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML Retrieved: 2026-10-09T20:27:02Z	source checked ["source-hash-verification","deterministic-table-parse","independent-cell-check"] · 2026-10-09 independent paper Audit details Extracted by deterministic parse of the article JATS XML table-wrap advs8741-tbl-0001 (extract/extract_ctdna_fragmentomics.py) with header and row labels asserted; the full cell text is in printed_source_cell. Independent review 2026-10-09: value and identity match the source. Field: `attributes.printed_value` Source artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Hash scope: Hash scope not separately documented; inspect source record Inspected artifact Extraction artifact SHA-256: `d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70` Extraction artifact

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Sources and history

Release 2026-10-09-ba02f2f4a36e · Record review: source checked

1 source records and release history

Systematically Evaluating Cell-Free DNA Fragmentation Patterns for Cancer Diagnosis and Enhanced Cancer Detection via Integrating Multiple Fragmentation Patterns · Original source · Advanced Science 11(30):e2308243, published 2024-06-17; PMC11321639 full-text XML

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Technical metadata and extraction receipts

Stable ID: ctdnafrag-20261009-result-hou2024-t1-fsd-pca-auroc

metric: auroc
metric qualifier: pan-cancer vs healthy; mean of 10 x 10-fold cross-validation
metric direction: higher
unit: unitless
printed value: 0.9229
numeric value: 0.9229
source locator: Article Table 1 (advs8741-tbl-0001), row 'FSD', column 'after PCA degradation'
review: method: source-hash-verification; deterministic-table-parse; independent-cell-check; method note: Re-downloaded the article XML and matched its SHA-256. Read table-wrap advs8741-tbl-0001 with a separate stdlib XML reader written for this review; the extractor's scripts were not imported or run. Built each cell's identity from the header row and row label, then checked the full cell text, printed value, numeric value, 95% CI, metric, qualifier, unit, direction, and the linked evaluation's configuration, protocol and dataset.; reviewer: claude; reviewer note: Separate Claude review agent, independent of the extractor; no human review claimed; date: 2026-10-09; artifact sha256: d029fc9d593a70fc350fa86cf1c6393ab5121479396b448ea2c0cdd87b6ace70; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC11321639/fullTextXML; note: Extracted by deterministic parse of the article JATS XML table-wrap advs8741-tbl-0001 (extract/extract_ctdna_fragmentomics.py) with header and row labels asserted; the full cell text is in printed_source_cell. Independent review 2026-10-09: value and identity match the source.
uncertainty: type: confidence_interval; lower: 0.9149; upper: 0.9308; level: 0.95; printed: 0.9149–0.9308
printed source cell: 0.9229 (0.9149–0.9308)

Related records

evaluation: FSD (open chromatin regions after PCA dimension reduction), pan-cancer vs healthy AUC

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