73% sensitivity_at_reported_98_percent_specificity
DELFI 2019 internally cross-validated cancer detection reported endpoint
- Tested configuration
- DELFI 2019 internally cross-validated cancer detection tested configuration
- Protocol
- DELFI 2019 internally cross-validated cancer detection protocol
- Dataset
- DELFI 2019 internally cross-validated cancer detection cohort
- Procedure
- amp-20261007-ctdna-fragmentomics-protocol
- Evaluation
- DELFI 2019 internally cross-validated cancer detection
- Coverage
- scored: unreported; eligible: unreported
- Uncertainty
- 95% CI 67%–79%; sensitivity intervals from 2,000 bootstrap replicates
- Evidence
- Author-reported evaluation · source checkedCristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 · PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11.
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: source checked. Source checked does not mean independently reproduced.
Reproduction
- Split
- 10-fold cross-validation repeated 10 times; feature selection and model estimation on training folds only
- Adaptation
- Supervised cohort-specific gradient boosting; not a foundation model
- Scoring implementation
- sensitivity_at_reported_98_percent_specificity
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 73% Individual claims | Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11. Version: Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 | source checked automated source review · 2026-10-07T12:29:33.932238+00:00 author reported Audit detailsCandidate extraction only; parent independent review required. No independent replication or human scientific review. Field: Source artifact SHA-256: Hash scope: Hash scope not separately documented; inspect source record Format: curator_factual_receipt |
Sources and history
View linked audit checks and correction history
Release 2026-10-07-1448159e6a81 · Record review: source checked
1 source records and release history
- Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252 · Original source · Cristiano et al., Nature 570, 385–389 (2019), author manuscript PMC6774252
Technical metadata and extraction receipts
Stable ID: amp-20261007-ctdna-fragmentomics-result
- areas
- dna-genomes
- method types
- supervised_machine_learning
- tasks
- cancer_detection
- denominator
- 208
- metric
- sensitivity_at_reported_98_percent_specificity
- metric direction
- higher
- missing metadata
- None recorded
- numerator
- 152
- numeric value
- 73
- printed value
- 73%
- review
- method: automated_source_review; notes: Candidate extraction only; parent independent review required. No independent replication or human scientific review.; reviewed at: 2026-10-07T12:29:33.932238+00:00; reviewer: Codex pathogens-fragmentomics evidence worker
- source locator
- PMC6774252 Table 1 T1 Cancer row / 98% specificity columns; Results P15; Methods P34; Extended Data Fig. 7 F11.
- uncertainty
- 95% CI 67%–79%; sensitivity intervals from 2,000 bootstrap replicates
- unit
- percent