Result

0.65 Lasso pearsonr (DNASE + RNA + CHIP)

AlphaGenome distilled multimodal DNase, RNA-seq and histone ChIP-seq features → per-locus LassoCV: Supervised multimodal CAGI5 MPRA prediction, Lasso pearsonr (DNASE + RNA + CHIP)

Tested pipeline: AlphaGenome distilled multimodal DNase, RNA-seq and histone ChIP-seq features → per-locus LassoCV
Protocol: Supervised multimodal CAGI5 MPRA prediction (AlphaGenome paper)
Dataset subset: Supervised multimodal CAGI5 MPRA prediction: evaluated data subset
Procedure: Generate multimodal features using the Borzoi-comparison scoring strategy, standardize from training statistics and fit per-locus LASSO.
Evaluation: AlphaGenome distilled multimodal DNase, RNA-seq and histone ChIP-seq features → per-locus LassoCV: Supervised multimodal CAGI5 MPRA prediction
Coverage: scored: unreported; eligible: unreported
Uncertainty: Not reported
Evidence: Author-reported evaluation · source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!M12

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: needs review. Source checked does not mean independently reproduced.

Reproduction

Split: Fit feature scaling on challenge training data only; tune a separate LassoCV per locus with10-fold cross-validation, then evaluate the challenge test set.
Adaptation: AlphaGenome distilled multimodal DNase, RNA-seq and histone ChIP-seq features → per-locus LassoCV
Scoring implementation: Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Access requirements and official instructions: Supervised multimodal CAGI5 MPRA prediction (AlphaGenome paper)

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

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Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

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1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-09-29-06401fd5b220
Property and statement	Original source and location	Review and provenance
Reported result 0.65 Individual claims	AlphaGenome Nature 2026 supplementary comparison tables Original source ↗ 'Suppl Table 4 Variant performan'!M12 Version: Nature version of record, 28 January 2026 Retrieved: 2026-09-17T06:31:06.887921+00:00	source checked OOXML extraction and separate automated primary-source review · 2026-09-17 author reported Audit details Checked against a second extraction. Fixed-format display and exact stored decimals preserved separately. No experiment rerun. Field: `attributes.printed_value` Source artifact SHA-256: `833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154` Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx Inspected artifact Extraction artifact SHA-256: `833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154` Extraction artifact

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Sources and history

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Release 2026-09-29-06401fd5b220 · Record review: source checked

3 source records and release history

AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied

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Technical metadata and extraction receipts

Stable ID: alphagenome-2026-result-e73a0458ca9cd659

areas: dna-genomes
printed value: 0.65
printed value basis: Workbook number format 0.00
numeric value: 0.65400000000000003
raw xml value: 0.65400000000000003
workbook number format: 0.00
metric: Lasso pearsonr (DNASE + RNA + CHIP)
metric direction: higher
unit: correlation
aggregation: Mean Pearson correlation across included locus/context tests. The figure-average protocol excludes MYC for LASSO non-convergence and TERT-GBM for matched comparisons.
uncertainty: Not reported
scored count: Not reported
eligible count: Not reported
source cells: 'Suppl Table 4 Variant performan'!M12
source locator: 'Suppl Table 4 Variant performan'!M12
review: method: OOXML extraction and separate automated primary-source review; date: 2026-09-17; artifact sha256: 833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154; retrieval url: https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41586-025-10014-0/MediaObjects/41586_2025_10014_MOESM3_ESM.xlsx; note: Checked against a second extraction. Fixed-format display and exact stored decimals preserved separately. No experiment rerun.
missing metadata: uncertainty: unreported; scored count: unextracted; eligible count: unextracted; seeds: unreported
source warnings: None recorded

Related records

evaluation: AlphaGenome distilled multimodal DNase, RNA-seq and histone ChIP-seq features → per-locus LassoCV: Supervised multimodal CAGI5 MPRA prediction

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