0.78 auprc
ENCODE-rE2G extended logistic regression plus AlphaGenome K562 RNA-seq input × gradient feature: Supervised enhancer–gene linking, auprc
- Tested pipeline
- ENCODE-rE2G extended logistic regression plus AlphaGenome K562 RNA-seq input × gradient feature
- Protocol
- Supervised enhancer–gene linking (AlphaGenome paper)
- Dataset subset
- Supervised enhancer–gene linking: evaluated data subset
- Procedure
- Add the K562 RNA-seq input×gradient score to ENCODE-rE2G extended, rerun its full logistic-regression training pipeline and evaluate out-of-fold predictions.
- Evaluation
- ENCODE-rE2G extended logistic regression plus AlphaGenome K562 RNA-seq input × gradient feature: Supervised enhancer–gene linking
- Coverage
- scored: unreported; eligible: unreported
- Uncertainty
- Not reported
- Evidence
- Author-reported evaluation · source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!M18
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: needs review. Source checked does not mean independently reproduced.
Reproduction
- Split
- ENCODE-rE2G out-of-fold prediction/training pipeline; reuse the authors’ cross-validated comparison scores and rerun the feature-augmented pipeline. Exact fold assignments are not enumerated in this methods paragraph.
- Adaptation
- ENCODE-rE2G extended logistic regression plus AlphaGenome K562 RNA-seq input × gradient feature
- Scoring implementation
- Not reported
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 0.78 Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!M18 Version: Nature version of record, 28 January 2026 | source checked OOXML extraction and separate automated primary-source review · 2026-09-17 author reported Audit detailsChecked against a second extraction. Fixed-format display and exact stored decimals preserved separately. No experiment rerun. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx Extraction artifact SHA-256: |
Sources and history
View linked audit checks and correction history
Release 2026-09-29-06401fd5b220 · Record review: source checked
3 source records and release history
- AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
- AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
- alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Technical metadata and extraction receipts
Stable ID: alphagenome-2026-result-5ef7238b75eb48d7
- areas
- dna-genomes
- printed value
- 0.78
- printed value basis
- Workbook number format 0.00
- numeric value
- 0.78100000000000003
- raw xml value
- 0.78100000000000003
- workbook number format
- 0.00
- metric
- auprc
- metric direction
- higher
- unit
- dimensionless
- aggregation
- auPRC over labelled element–gene pairs, with separate distance-to-TSS strata in the paper.
- uncertainty
- Not reported
- scored count
- Not reported
- eligible count
- Not reported
- source cells
- 'Suppl Table 4 Variant performan'!M18
- source locator
- 'Suppl Table 4 Variant performan'!M18
- review
- method: OOXML extraction and separate automated primary-source review; date: 2026-09-17; artifact sha256: 833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154; retrieval url: https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41586-025-10014-0/MediaObjects/41586_2025_10014_MOESM3_ESM.xlsx; note: Checked against a second extraction. Fixed-format display and exact stored decimals preserved separately. No experiment rerun.
- missing metadata
- uncertainty: unreported; scored count: unextracted; eligible count: unextracted; seeds: unreported
- source warnings
- None recorded