AUROC (tissue-weighted mean) of AlphaGenome absolute multimodal scores → RandomForestClassifier on Supervised distance-balanced eQTL causality: evaluated data subset
0.8 AUROC (tissue-weighted mean)
Methods
- Tested pipeline
- AlphaGenome absolute multimodal scores → RandomForestClassifier
- Protocol
- Supervised distance-balanced eQTL causality (AlphaGenome paper)
- Dataset subset
- Supervised distance-balanced eQTL causality: evaluated data subset
- Procedure
- Train the source’s random-forest classifier on the same balanced causality dataset and score the held-out chromosome test set.
- Evaluation
- AlphaGenome absolute multimodal scores → RandomForestClassifier: Supervised distance-balanced eQTL causality
- Coverage
- Not reported scored / Not reported eligible
- Uncertainty
- Not reported by the source
- Evidence
- Author-reported evaluation · source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!M14
A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: needs review. Source checked does not mean independently reproduced.
Reproduction
- Split
- Supervised training chromosomes are 1,4,7,8,10,13,15; validation chromosomes 2,5,11,14,17,20,22,X; test chromosomes 3,6,9,12,16,18,19,21. This is downstream evaluation separation, not a held-out reference-genome claim for the distilled backbone. The task additionally describes five-fold random-forest training excluding test chromosomes, followed by mean test auROC across those fits; exact fold membership is not enumerated.
- Adaptation
- AlphaGenome absolute multimodal scores → RandomForestClassifier
- Scoring implementation
- Not reported
No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.
Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
1 evidence row matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|---|---|
| Reported result 0.80 Individual claims | AlphaGenome Nature 2026 supplementary comparison tables 'Suppl Table 4 Variant performan'!M14 Version: Nature version of record, 28 January 2026 | source checked ["deterministic-table-parse","automated-source-review"] · 2026-09-17 author reported Audit detailsChecked against a second extraction. Fixed-format display and exact stored decimals preserved separately. No experiment rerun. Field: Source artifact SHA-256: Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx Extraction artifact SHA-256: |
Sources and history
Release 2026-11-02-a7f03c9e55a5 · Record review: source checked
3 source records and release history
- AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
- AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
- alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied
Technical metadata and extraction receipts
Stable ID: alphagenome-2026-result-5059e5c4d8ea60db
- areas
- dna-genomes
- printed value
- 0.80
- printed value basis
- Workbook number format 0.00
- numeric value
- 0.799775799314286
- raw xml value
- 0.799775799314286
- workbook number format
- 0.00
- metric
- auroc
- metric direction
- higher
- unit
- unitless
- aggregation
- auROC per tissue weighted by the tissue’s variant count; the supervised analysis additionally averages auROC across five fitted folds.
- source cells
- 'Suppl Table 4 Variant performan'!M14
- source locator
- 'Suppl Table 4 Variant performan'!M14
- review
- method: deterministic-table-parse; automated-source-review; date: 2026-09-17; artifact sha256: 833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154; retrieval url: https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41586-025-10014-0/MediaObjects/41586_2025_10014_MOESM3_ESM.xlsx; note: Checked against a second extraction. Fixed-format display and exact stored decimals preserved separately. No experiment rerun.; method note: OOXML extraction; separate automated review against the primary source
- missing metadata
- eligible count: reason: unextracted; scored count: reason: unextracted; seeds: reason: unreported; uncertainty: reason: unreported
- source warnings
- None recorded
- metric qualifier
- tissue-weighted mean