Result

0.8 tissue_weighted_mean_auroc

AlphaGenome absolute multimodal scores → RandomForestClassifier: Supervised distance-balanced eQTL causality, tissue weighted mean auroc

Tested pipeline: AlphaGenome absolute multimodal scores → RandomForestClassifier
Protocol: Supervised distance-balanced eQTL causality (AlphaGenome paper)
Dataset subset: Supervised distance-balanced eQTL causality: evaluated data subset
Procedure: Train the source’s random-forest classifier on the same balanced causality dataset and score the held-out chromosome test set.
Evaluation: AlphaGenome absolute multimodal scores → RandomForestClassifier: Supervised distance-balanced eQTL causality
Coverage: scored: unreported; eligible: unreported
Uncertainty: Not reported
Evidence: Author-reported evaluation · source checkedAlphaGenome Nature 2026 supplementary comparison tables · 'Suppl Table 4 Variant performan'!M14

A source-checked result verifies the numerical transcription, not every model or protocol detail. Evaluation metadata: needs review. Source checked does not mean independently reproduced.

Reproduction

Split: Supervised training chromosomes are 1,4,7,8,10,13,15; validation chromosomes 2,5,11,14,17,20,22,X; test chromosomes 3,6,9,12,16,18,19,21. This is downstream evaluation separation, not a held-out reference-genome claim for the distilled backbone. The task additionally describes five-fold random-forest training excluding test chromosomes, followed by mean test auROC across those fits; exact fold membership is not enumerated.
Adaptation: AlphaGenome absolute multimodal scores → RandomForestClassifier
Scoring implementation: Not reported

No execution recipe has been verified for this exact configuration and evaluation. A benchmark's general instructions may use different inputs, splits or model settings.

Access requirements and official instructions: Supervised distance-balanced eQTL causality (AlphaGenome paper)

Reproducing this published result requires matching its model configuration, data, split and scorer. Source checking or a successful smoke test does not establish score reproduction.

Evidence

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Evidence table

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Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.

One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.

1 evidence row matching the loaded filters

Claims, original sources and review scope · Release 2026-09-29-06401fd5b220
Property and statement	Original source and location	Review and provenance
Reported result 0.80 Individual claims	AlphaGenome Nature 2026 supplementary comparison tables Original source ↗ 'Suppl Table 4 Variant performan'!M14 Version: Nature version of record, 28 January 2026 Retrieved: 2026-09-17T06:31:06.887921+00:00	source checked OOXML extraction and separate automated primary-source review · 2026-09-17 author reported Audit details Checked against a second extraction. Fixed-format display and exact stored decimals preserved separately. No experiment rerun. Field: `attributes.printed_value` Source artifact SHA-256: `833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154` Hash scope: SHA-256 of exact retrieved original artifact bytes Format: xlsx Inspected artifact Extraction artifact SHA-256: `833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154` Extraction artifact

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Sources and history

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Release 2026-09-29-06401fd5b220 · Record review: source checked

3 source records and release history

AlphaGenome Nature 2026 supplementary comparison tables · Original source · Nature version of record, 28 January 2026
AlphaGenome Nature 2026 supplementary methods · Original source · Supplement to Nature version of record, 28 January 2026; content hash pinned
alphagenome: Journal full-text XML · Original source · Retrieved page snapshot; no immutable publisher revision supplied

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Technical metadata and extraction receipts

Stable ID: alphagenome-2026-result-5059e5c4d8ea60db

areas: dna-genomes
printed value: 0.80
printed value basis: Workbook number format 0.00
numeric value: 0.799775799314286
raw xml value: 0.799775799314286
workbook number format: 0.00
metric: tissue_weighted_mean_auroc
metric direction: higher
unit: dimensionless
aggregation: auROC per tissue weighted by the tissue’s variant count; the supervised analysis additionally averages auROC across five fitted folds.
uncertainty: Not reported
scored count: Not reported
eligible count: Not reported
source cells: 'Suppl Table 4 Variant performan'!M14
source locator: 'Suppl Table 4 Variant performan'!M14
review: method: OOXML extraction and separate automated primary-source review; date: 2026-09-17; artifact sha256: 833cb78b6ae6fe39415cfff296ac00c48d800326139f13eb307531a1cc133154; retrieval url: https://media.springernature.com/original/springer-static/esm/art%3A10.1038%2Fs41586-025-10014-0/MediaObjects/41586_2025_10014_MOESM3_ESM.xlsx; note: Checked against a second extraction. Fixed-format display and exact stored decimals preserved separately. No experiment rerun.
missing metadata: uncertainty: unreported; scored count: unextracted; eligible count: unextracted; seeds: unreported
source warnings: None recorded

Related records

evaluation: AlphaGenome absolute multimodal scores → RandomForestClassifier: Supervised distance-balanced eQTL causality

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