Perturbation-first AUROC, K562 CRISPRa (Kendiukhov 2026)
As the K562 CRISPRi protocol, on the K562 CRISPRa dataset cited as reference 25.
No reviewed evaluations are linked here in this release. See the sources below.
Overview
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Published results still to collect
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Methods and evaluation design
Procedure, tasks and evaluated configurations
Recorded evaluations
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Baseline coverage
Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.
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No reviewed evaluations with results linked in this release.
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Null control
Proposed control: requires review
No-change prediction under matched control conditions
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This is a suggested selection rule, not a validated method or a measured score.
Conventional reference
Proposed control: requires review
Training-only mean-effect or linear prediction
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This is a suggested selection rule, not a validated method or a measured score.
Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)
Coverage is derived from release 2026-11-02-a7f03c9e55a5. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.
Run instructions
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Evidence
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Evidence table
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Sources and history
Release 2026-11-02-a7f03c9e55a5 · Record review: source checked
1 source record and release history
- Systematic evaluation of single-cell foundation model interpretability: attention-derived edge scores add no incremental value over gene-level features for perturbation-target prediction (Kendiukhov 2026, BMC Genomics 27:634) · Original source · Version of record, BMC Genomics 27:634, published 2026-07-22 (received 2026-03-10, accepted 2026-05-14)
Technical metadata and extraction receipts
Stable ID: gfm-guides-20261014-kendiukhov2026-protocol-pf-k562-crispra
- areas
- single-cell; biological-networks
- contexts
- research
- protocol
- As the K562 CRISPRi protocol, on the K562 CRISPRa dataset cited as reference 25.
- version
- BMC Genomics 27:634
- metric
- auroc
- metric direction
- higher
- unit
- unitless
- metric implementation
- Per-perturbation AUROC for classifying differentially expressed targets (Mann-Whitney U test with Benjamini-Hochberg correction and an LFC threshold define DE hits); summary across perturbations not stated
- source locator
- Page 10, 'Context-dependent attention-correlation relationship'
- limitations
- Single run; no repeat across seeds reported for these values.