ClinVar missense pathogenicity, ESM1b versus EVE on variants scored by both (Brandes et al. 2023 Fig. 2b, Results text)
Global ROC-AUC of ESM1b and EVE on the ClinVar variants scored by both, as quoted in the Results.
No reviewed evaluations are linked here in this release. See the sources below.
Overview
An explanatory profile has not yet been reviewed for this record.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Published results still to collect
This release has no source-checked evaluations linked to this page. It does not mean that the benchmark has no published results.
Charts will appear when compatible result tables have been checked against their sources.
Methods and evaluation design
Procedure, tasks and evaluated configurations
Recorded evaluations
Each evaluation records what was tested and under which conditions.
Baseline coverage
Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.
0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.
No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.
No reviewed evaluations with results linked in this release.
Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.
Null control
Proposed control: requires review
Select a task-valid null control after reviewing inputs and metric
Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.
This is a suggested selection rule, not a validated method or a measured score.
Conventional reference
Proposed control: requires review
Select an upstream conventional reference after reviewing the full protocol
Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.
This is a suggested selection rule, not a validated method or a measured score.
Protocol coverage CSV (gzip) · Model evaluation matrix (gzip) · Source table (gzip) · Release and checksums (gzip)
Coverage is derived from release 2026-10-22-1b7cf027e4f6. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.
Run instructions
No runnable recipe has been reviewed for this protocol. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.
Strengths, limitations and unresolved questions
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
0 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|
No evidence rows match these filters. Choose another scope or clear the search.
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Genome-wide prediction of disease variant effects with a deep protein language model (Brandes et al., Nature Genetics 2023) · Original source · Version of record, Nature Genetics 55, 1512-1522 (published 2023-08-10)
Technical metadata and extraction receipts
Stable ID: gfm-guides-20261014-esm1b-protocol-clinvar-esm1b-eve-shared
- areas
- dna-genomes; protein-function
- contexts
- clinical_research
- protocol
- Global ROC-AUC over the variants with both ESM1b and EVE scores.
- version
- Results text (Fig. 2b)
- metric
- auroc
- metric direction
- higher
- unit
- unitless
- denominator
- 36537
- limitations
- Benchmark built by the ESM1b workflow's authors (author-reported for ESM1b).; Supplementary Table 2's EVE head-to-head row gives slightly different values and counts (see the article source's limitations).
- source locator
- Results 'ESM1b outperforms other VEP methods over clinical and experimental benchmarks' paragraph 2; Fig. 2b legend
Related records
- part of: Brandes et al. 2023 clinical missense pathogenicity benchmarks (ClinVar and HGMD/gnomAD)
- uses data: ClinVar missense pathogenic vs benign, primary isoforms (Brandes et al. 2023, from the EVE portal)
- assessment: ESM1b on ClinVar missense, ESM1b versus EVE shared variants (Brandes et al. 2023 Results)
- assessment: EVE on ClinVar missense, ESM1b versus EVE shared variants (Brandes et al. 2023 Results)