NCH clinically relevant fusion ascertainment
NCH clinically relevant fusion ascertainment; bounded primary-source AMP candidate.
Overview
NCH clinically relevant fusion ascertainment; bounded primary-source AMP candidate.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
2 recorded evaluations, 4 metric rows. A comparison chart has not yet been validated for these results. The table retains the individual findings and their sources.
Results
Results are available, but no reviewed comparison panel is linked in this release.
All evaluations
2 evaluations · 4 results. Different protocols are not a single leaderboard.
Filter evaluations
Applied filters: All linked evaluations
| Tested configuration | Protocol and dataset | Finding | Evidence and details |
|---|---|---|---|
| Configuration: Arriba | Protocol: NCH clinically relevant fusion ascertainment Dataset: Nationwide Children hospital pediatric cancer/hematologic cohort | 59 clinically relevant fusions called fusions · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceArriba NCH clinical-ascertainment evaluation name: NCH clinically relevant fusion ascertainment; proposed id: amp-oncology-rna-20261007-protocol-enfusion-nch-clinical; version: 2021 article Table 1 Aggregation: Not reported Discovery of clinically relevant fusions in pediatric cancer · Table 1, Arriba row, Sensitivity column (JATS Tab1) |
| Configuration: Arriba | Protocol: NCH clinically relevant fusion ascertainment Dataset: Nationwide Children hospital pediatric cancer/hematologic cohort | 88.1% sensitivity among ensemble-ascertained clinically relevant fusions % · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceArriba NCH clinical-ascertainment evaluation name: NCH clinically relevant fusion ascertainment; proposed id: amp-oncology-rna-20261007-protocol-enfusion-nch-clinical; version: 2021 article Table 1 Aggregation: Not reported Discovery of clinically relevant fusions in pediatric cancer · Table 1, Arriba row, Sensitivity column (JATS Tab1) |
| Configuration: STAR-Fusion | Protocol: NCH clinically relevant fusion ascertainment Dataset: Nationwide Children hospital pediatric cancer/hematologic cohort | 63 clinically relevant fusions called fusions · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSTAR-Fusion NCH clinical-ascertainment evaluation name: NCH clinically relevant fusion ascertainment; proposed id: amp-oncology-rna-20261007-protocol-enfusion-nch-clinical; version: 2021 article Table 1 Aggregation: Not reported Discovery of clinically relevant fusions in pediatric cancer · Table 1, STAR-Fusion row, Sensitivity column (JATS Tab1) |
| Configuration: STAR-Fusion | Protocol: NCH clinically relevant fusion ascertainment Dataset: Nationwide Children hospital pediatric cancer/hematologic cohort | 94% sensitivity among ensemble-ascertained clinically relevant fusions % · higher Uncertainty: Not reported Coverage: Not reported scored / Not reported eligible | Independent external evaluation · Source checkedMethods, coverage and sourceSTAR-Fusion NCH clinical-ascertainment evaluation name: NCH clinically relevant fusion ascertainment; proposed id: amp-oncology-rna-20261007-protocol-enfusion-nch-clinical; version: 2021 article Table 1 Aggregation: Not reported Discovery of clinically relevant fusions in pediatric cancer · Table 1, STAR-Fusion row, Sensitivity (clinically relevant fusions called out of 67) column (JATS Tab1) |
Source checking is not independent reproduction. Release 2026-10-07-1448159e6a81.
Methods and evaluation design
Procedure, tasks and evaluated configurations
Recorded evaluations
Each evaluation records what was tested and under which conditions.
Baseline coverage
Reference methods help show what a model adds beyond simple controls. We track a null control and a conventional method for each protocol.
0 of 2 active baseline roles have published Rewire measurements in this release. Measurements on a selected protocol do not establish coverage of an entire suite.
No execution recipe linked to this protocol. Recipe availability does not establish a completed evaluation.
- External evaluations
- 2
Literature evidence is not a Rewire measurement. Executed but unpublished runs and private review status are not included.
Null control
Proposed control: requires review
Select a task-valid null control after reviewing inputs and metric
Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.
This is a suggested selection rule, not a validated method or a measured score.
Conventional reference
Proposed control: requires review
Select an upstream conventional reference after reviewing the full protocol
Protocol-specific applicability, permitted inputs, access, split, evaluator and execution requirements need review before implementation or execution.
This is a suggested selection rule, not a validated method or a measured score.
Protocol coverage CSV · Model evaluation matrix · Source table · Release and checksums
Coverage is derived from release 2026-10-07-1448159e6a81. Source citations describe the original records; they do not validate an unreviewed baseline proposal. No results have been generated by this audit.
Run instructions
No runnable recipe has been reviewed for this protocol. Dataset access, model requirements, licences and compute requirements must be checked against its sources before execution.
Strengths, limitations and unresolved questions
Evidence
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Evidence table
Inspect claims, sources and review details
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One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
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Sources and history
View linked audit checks and correction history
Release 2026-10-07-1448159e6a81 · Record review: source checked
1 source records and release history
- Discovery of clinically relevant fusions in pediatric cancer · Original source · Europe PMC fullTextXML retrieved 2026-10-07T12:25:20.810843+00:00
Technical metadata and extraction receipts
Stable ID: amp-oncology-rna-20261007-protocol-enfusion-nch-clinical
- areas
- dna-genomes
- method types
- conventional_pipeline
- missing metadata
- None recorded
- scope note
- Ascertainment is from the optimized EnFusion pipeline; denominator is not an independent exhaustive truth set. Only a subset orthogonally confirmed; the endpoint does not quantify novel fusion generalization or patient outcomes. Do not combine with duplicate Seraseq measurements.
- task
- 67 clinically relevant fusions in 229 pediatric cancer/hematologic samples
- version
- 2021 article Table 1