PromoterAI
Deep learning model that predicts the impact of promoter variants on gene expression. Scores range from -1 to 1 (negative for under-expression, positive for over-expression); the README recommends thresholds of 0.1, 0.2 and 0.5 in absolute value. Supports single nucleotide variants and left-normalised indels.
No reviewed evaluations are linked here in this release. See the sources below.
Overview
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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Use this model
How it works, versions and access
Strengths, limitations and unresolved questions
Evidence
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Evidence table
Inspect claims, sources and review details
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: discovered
1 source record and release history
- Illumina/PromoterAI repository README (paper: Jaganathan et al. 2025, Science 389:eads7373, not retrieved) (repository README at commit) · Original source · Illumina/PromoterAI README at commit ce9fcd080556d7e962a5946327fe8fd1a04e272b
Technical metadata and extraction receipts
Stable ID: vep-uc-20261014-model-promoterai
- areas
- dna-genomes
- contexts
- research; clinical_research
- method types
- supervised_machine_learning
- reported name
- PromoterAI
- entity level
- family
- access
- pip package 'promoterai' and source code in the repository; precomputed scores for all human promoter SNVs after a licence agreement; commercial use by agreement with Illumina (README)
- source locator
- README
- missing metadata
- training data: reason: unextracted; version: reason: unreported; note: The source names no release or version for the tool
- licence
- Repository licence not asserted by GitHub; precomputed scores for academic and non-commercial use under a licence agreement (README)
- review
- reviewer: claude; reviewer note: Claude review agent; no human review claimed. Independent Claude (Opus 5.5) review agent, separate from the extraction agent that built this batch. Automated review only. Transcription, not reproduction.; reviewed at: 2026-10-14T16:00:00Z; artifact sha256: 1446b5732ea0aaa243d930ff5d13873b275d63fca3e6c1dbfcedd23a334e9519; retrieval url: https://raw.githubusercontent.com/Illumina/PromoterAI/ce9fcd080556d7e962a5946327fe8fd1a04e272b/README.md; method: source-hash-verification; ai-assisted-source-review; method note: Re-downloaded the primary source and matched its SHA-256; checked name, description, access URLs (each found in the source text), version and method type against it.; note: No fact taken from the AVE predictor list.