Model

Llama 3.3 70B Instruct

Evidence concern: excluded from comparisons

Appendix A.2 describes the random baseline as predicting hit with probability equal to 'the overall proportion of actual hits in the specific benchmark dataset'. With one pooled rate (485 of 1,175 = 41.3%, Table 3) the expected PPV, sensitivity, F1 and FPR are all about 0.41 and specificity and NPV about 0.59. Table 8 prints PPV 0.47, sensitivity 0.46, F1 0.47, FPR 0.36, specificity 0.64 and NPV 0.63. With each screen's own hit rate (Table 3) the expected values are 0.47, 0.47, 0.47, 0.37, 0.63 and 0.63, which match. One draw at the pooled rate would need sensitivity about 2 standard errors above and FPR about 3 below expectation at once. The baseline therefore probably uses per-screen hit rates, which is information a screen designer would not have before the screen. The expected values were computed by the reviewer from Table 3 counts and are not stored as results. Treat the random row as a per-screen-prevalence classifier, not a matched random-selection comparator.Virtual CRISPR: Can LLMs Predict CRISPR Screen Results? · Appendix A.2; Table 3; Table 1, row "Random Baseline"; Table 8, row "Random N/A N/A"

Instruction-tuned 70-billion-parameter text model in Meta's Llama 3.3 release of open-weight language models.

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Llama-3.3-70B, direct prompting, mean over prompting strategies (Song et al. 2025) Configuration · configuration of this model · 1 evaluation · 2 results

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Claims, original sources and review scope · Release 2026-10-23-5347695500ed
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Virtual CRISPR: Can LLMs Predict CRISPR Screen Results? · Original source · Proceedings of the 24th Workshop on Biomedical Language Processing (BioNLP 2025), pages 354-364, 1 August 2025; ACL Anthology 2025.bionlp-1.30

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Stable ID: pheno-20261022-model-song2025-llama-3-3-70b

areas: cells-tissues
contexts: research
method types: foundation_model
entity level: checkpoint
reported name: Llama-3.3-70B
version: meta-llama/Llama-3.3-70B-Instruct
access: Open weights from Hugging Face, served with vLLM
source locator: Appendix Table 7; Appendix A.1
provenance note: Version string as printed in Appendix Table 7 of Song et al. 2025. The description is general knowledge of the model line, not taken from the source.
missing metadata: training data: reason: unreported

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configuration of: Llama-3.3-70B, direct prompting, mean over prompting strategies (Song et al. 2025)

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