PrimateAI-3D
Semi-supervised 3D convolutional neural network on voxelised protein structures, trained to separate common missense variants observed in 233 primate species from matched control variants, to predict the pathogenicity of human missense variants. Distinct from PrimateAI, which has its own record.
No reviewed evaluations are linked here in this release. See the sources below.
Overview
An explanatory profile has not yet been reviewed for this record.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Use this method
How it works, versions and access
Strengths, limitations and unresolved questions
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
0 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|
No evidence rows match these filters. Choose another scope or clear the search.
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: discovered
1 source record and release history
- Gao et al. 2023, Science 380(6648) (PMC article page) · Original source · PMC10713091, NIH author manuscript of Science 2023;380(6648):eabn8153 as printed in the page metadata
Technical metadata and extraction receipts
Stable ID: vep-uc-20261014-method-primateai-3d
- areas
- dna-genomes; proteins-complexes
- contexts
- clinical_research
- method types
- supervised_machine_learning
- reported name
- PrimateAI-3D
- entity level
- method
- access
- Paper lists https://github.com/lllumina/PrimateAI-3D and https://primad.basespace.illumina.com (paper text, as printed)
- source locator
- Abstract; availability statements
- missing metadata
- version: reason: unreported; note: The source names no release or version for the tool
- review
- reviewer: claude; reviewer note: Claude review agent; no human review claimed. Independent Claude (Opus 5.5) review agent, separate from the extraction agent that built this batch. Automated review only. Transcription, not reproduction.; reviewed at: 2026-10-14T16:00:00Z; artifact sha256: 34a641a6fe9b14d8ca40854061ef62047c974873456ba6419a60b34379e2351a; retrieval url: https://pmc.ncbi.nlm.nih.gov/articles/PMC10713091/; method: source-hash-verification; ai-assisted-source-review; method note: Re-downloaded the primary source and matched its SHA-256; checked name, description, access URLs (each found in the source text), version and method type against it.; note: No fact taken from the AVE predictor list.