MutaPheno
Random forest classifier trained on 67,791 pathogenic and benign missense variants mapped to AlphaFold2 structures, using 34 residue-, mutation- and protein-level molecular features; the authors apply it to predicting cancer driver missense mutations.
No reviewed evaluations are linked here in this release. See the sources below.
Overview
An explanatory profile has not yet been reviewed for this record.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Use this method
How it works, versions and access
Strengths, limitations and unresolved questions
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
0 evidence rows matching the loaded filters
| Property and statement | Original source and location | Review and provenance |
|---|
No evidence rows match these filters. Choose another scope or clear the search.
Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: discovered
1 source record and release history
- Yang et al. 2026, PNAS 123:e2524289123 (Europe PMC full text XML) · Original source · PMC12890849 (PNAS 2026;123(6):e2524289123; published version of the 2025 bioRxiv preprint 10.1101/2025.09.03.674130)
Technical metadata and extraction receipts
Stable ID: vep-uc-20261014-method-mutapheno
- areas
- dna-genomes; proteins-complexes
- contexts
- clinical_research
- method types
- supervised_machine_learning
- reported name
- MutaPheno
- entity level
- method
- access
- Code at https://github.com/minghuilab/MutaPheno (paper text)
- source locator
- Abstract; availability statements
- missing metadata
- version: reason: unreported; note: The source names no release or version for the tool
- review
- reviewer: claude; reviewer note: Claude review agent; no human review claimed. Independent Claude (Opus 5.5) review agent, separate from the extraction agent that built this batch. Automated review only. Transcription, not reproduction.; reviewed at: 2026-10-14T16:00:00Z; artifact sha256: 54c16ac9a0da2607496a7a464d0186c12f2de0f885c40d739f83fe17f6d1a3d1; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12890849/fullTextXML; method: source-hash-verification; ai-assisted-source-review; method note: Re-downloaded the primary source and matched its SHA-256; checked name, description, access URLs (each found in the source text), version and method type against it.; note: No fact taken from the AVE predictor list.