LYRUS
XGBoost classifier of single amino acid variant pathogenicity using five sequence-based, six structure-based and four dynamics-based features, including a co-evolution feature (variation number). Trained on 22,639 ClinVar variants in 4,363 protein structures.
No reviewed evaluations are linked here in this release. See the sources below.
Overview
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Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Use this method
How it works, versions and access
Strengths, limitations and unresolved questions
Evidence
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Evidence table
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: discovered
1 source record and release history
- Lai et al. 2022, Bioinformatics Advances 2:vbab045 (Europe PMC full text XML) · Original source · PMC8754197 (Bioinformatics Advances 2022;2:vbab045)
Technical metadata and extraction receipts
Stable ID: vep-uc-20261014-method-lyrus
- areas
- dna-genomes; proteins-complexes
- contexts
- clinical_research
- method types
- supervised_machine_learning
- reported name
- LYRUS
- entity level
- method
- access
- Source code at https://github.com/jiaying2508/LYRUS (Abstract)
- source locator
- Abstract; availability statements
- missing metadata
- version: reason: unreported; note: The source names no release or version for the tool
- review
- reviewer: claude; reviewer note: Claude review agent; no human review claimed. Independent Claude (Opus 5.5) review agent, separate from the extraction agent that built this batch. Automated review only. Transcription, not reproduction.; reviewed at: 2026-10-14T16:00:00Z; artifact sha256: 73336d1bcfc7ecf023154c468f2e832935181c9af1bfeac90b12123fc00e5fdd; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC8754197/fullTextXML; method: source-hash-verification; ai-assisted-source-review; method note: Re-downloaded the primary source and matched its SHA-256; checked name, description, access URLs (each found in the source text), version and method type against it.; note: No fact taken from the AVE predictor list.