HomolVar
Web server that annotates the pathogenicity of a missense variant from annotated variants at the equivalent position in homologous proteins, developed on proteins involved in autosomal dominant diseases.
No reviewed evaluations are linked here in this release. See the sources below.
Overview
An explanatory profile has not yet been reviewed for this record.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Use this method
How it works, versions and access
Strengths, limitations and unresolved questions
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
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One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: discovered
1 source record and release history
- Ruiz-Alías et al. 2025, Bioinformatics 41:btaf305 (Europe PMC full text XML) · Original source · PMC12122210 (Bioinformatics 2025;41:btaf305)
Technical metadata and extraction receipts
Stable ID: vep-uc-20261014-method-homolvar
- areas
- dna-genomes; proteins-complexes
- contexts
- clinical_research
- method types
- specialist
- reported name
- HomolVar
- entity level
- method
- access
- Web server at https://rarevariants.org/HomolVar (Abstract)
- source locator
- Abstract; availability statements
- missing metadata
- version: reason: unreported; note: The source names no release or version for the tool
- review
- reviewer: claude; reviewer note: Claude review agent; no human review claimed. Independent Claude (Opus 5.5) review agent, separate from the extraction agent that built this batch. Automated review only. Transcription, not reproduction.; reviewed at: 2026-10-14T16:00:00Z; artifact sha256: a477b0d6208e258d0ea1d962576b615589611741cff19ac4906c9585de04fc6d; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC12122210/fullTextXML; method: source-hash-verification; ai-assisted-source-review; method note: Re-downloaded the primary source and matched its SHA-256; checked name, description, access URLs (each found in the source text), version and method type against it.; note: No fact taken from the AVE predictor list.