Evolutionary Action (EA)
Evolutionary Action: estimates the effect of a coding mutation on fitness as the product of the evolutionary importance of the mutated site and the difference in amino acid similarity, both approximated from phylogenetic sequence analysis.
Results are recorded on linked configurations and versions of this method. Their settings and evaluations are kept separate below.
Results on linked records
This method has no results of its own in this release. One linked record has results. They are not assigned to the underlying method: each record keeps its own settings and evaluations, and its scores are on its own page.
- EA (Pejaver et al. 2022 calibration) Configuration · configuration · 1 evaluation · 8 results
Overview
An explanatory profile has not yet been reviewed for this record.
Consult the linked sources for architecture or protocol details. Missing evidence is not evidence of a missing capability.
Use this method
How it works, versions and access
Strengths, limitations and unresolved questions
Evidence
Source checking verifies the cited claim or transcription. It does not establish independent reproduction.
Evidence table
Inspect claims, sources and review details
Trace each statement to its source and review. A context-only reference supports the record generally; it does not verify an individual field. Source checking does not reproduce an experiment.
One row per statement and cited source. Multiple citations are not independent evaluations. Shared locators are labelled explicitly.
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Sources and history
Release 2026-10-22-1b7cf027e4f6 · Record review: source checked
1 source record and release history
- Katsonis and Lichtarge 2014, Genome Research 24:2050 (Europe PMC full text XML) · Original source · PMC4248321 (Genome Res 2014;24:2050)
Technical metadata and extraction receipts
Stable ID: vep-uc-20261014-method-ea
- areas
- dna-genomes; proteins-complexes
- contexts
- clinical_research
- method types
- specialist
- reported name
- EA
- entity level
- method
- access
- Server at http://mammoth.bcm.tmc.edu/EvolutionaryAction (paper text)
- source locator
- Abstract; availability statements
- missing metadata
- version: reason: unreported; note: The source names no release or version for the tool
- review
- reviewer: claude; reviewer note: Claude review agent; no human review claimed. Independent Claude (Opus 5.5) review agent, separate from the extraction agent that built this batch. Automated review only. Transcription, not reproduction.; reviewed at: 2026-10-14T16:00:00Z; artifact sha256: 4838b3936b4e35a20d397ca3ce61081da94d68e38f7f7389de8bcfb4388bcc66; retrieval url: https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4248321/fullTextXML; method: source-hash-verification; ai-assisted-source-review; method note: Re-downloaded the primary source and matched its SHA-256; checked name, description, access URLs (each found in the source text), version and method type against it.; note: No fact taken from the AVE predictor list.
Related records
- configuration of: EA (Pejaver et al. 2022 calibration)